Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Aneesh Chandrasekharan"'
Autor:
Shine Varghese Jancy, Santhik Subhasingh Lupitha, Aneesh Chandrasekharan, Shankara Narayanan Varadarajan, Shijulal Nelson-Sathi, Roshny Prasad, Sara Jones, Sreekumar Easwaran, Pramod Darvin, Aswathy Sivasailam, Thankayyan Retnabai Santhoshkumar
Publikováno v:
Biological Procedures Online, Vol 25, Iss 1, Pp 1-15 (2023)
Abstract Background The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the host cell is mediated through the binding of the SARS-CoV-2 Spike protein via the receptor binding domain (RBD) to human angiotensin-converting enz
Externí odkaz:
https://doaj.org/article/1349fc4b8aee440e8289ad842f26392f
Autor:
Aneesh Chandrasekharan, Shankara Narayanan Varadarajan, Asha Lekshmi, Santhik Subhasingh Lupitha, Pramod Darvin, Leena Chandrasekhar, Prakash Rajappan Pillai, T.R. Santhoshkumar, M. Radhakrishna Pillai
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 379-389 (2019)
Most toxic compounds including cancer drugs target mitochondria culminating in its permeabilization. Cancer drug-screening and toxicological testing of compounds require cost-effective and sensitive high-throughput methods to detect mitochondrial dam
Externí odkaz:
https://doaj.org/article/ba0f3e37057146e5b556b05dae8e3873
Autor:
Santhik Subhasingh Lupitha, Pramod Darvin, Aneesh Chandrasekharan, Shankara Narayanan Varadarajan, Soumya Jaya Divakaran, Sreekumar Easwaran, Shijulal Nelson-Sathi, Perunthottathu K Umasankar, Sara Jones, Iype Joseph, Madhavan Radhakrishna Pillai, Thankayyan Retnabai Santhoshkumar
Publikováno v:
Antibody Therapeutics. 5:100-110
Quantitative determination of neutralizing antibodies against Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) is paramount in immunodiagnostics, vaccine efficacy testing, and immune response profiling among the vaccinated population. Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3d918a3962dcbe897470d507301f88
https://doi.org/10.1093/abt/tbac007
https://doi.org/10.1093/abt/tbac007
Autor:
Shankara Narayanan Varadarajan, Krupa Ann Mathew, Aneesh Chandrasekharan, Santhik Subhasingh Lupitha, Asha Lekshmi, Minsa Mini, Pramod Darvin, T. R. Santhoshkumar
Publikováno v:
Journal of Cellular Biochemistry. 123:782-797
Cancer cells grown as 3D-structures are better models for mimicking in vivo conditions than the 2D-culture systems employable in drug discovery applications. Cell cycle and cell death are important determinants for preclinical drug screening and tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b4f264cc969749a287fa851e159d88
https://doi.org/10.1002/jcb.30222
https://doi.org/10.1002/jcb.30222
Autor:
Vibin Ramakrishnan, Ruchika Goyal, Aneesh Chandrasekharan, Gaurav Jerath, Yvonne Christian, T. R. Santhosh Kumar
Publikováno v:
Drug Delivery and Translational Research. 12:1285-1292
A complete peptide-based drug delivery unit has been designed with a tumor homing domain chemically linked to a syndiotactic cell-penetrating domain. The designed peptides were synthesized, characterized, and tested in vitro for cellular uptake and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff60139ce88498150f5c09a98353e504
https://doi.org/10.1007/s13346-021-01035-z
https://doi.org/10.1007/s13346-021-01035-z
Autor:
Rishith Ravindran, Anoop Kumar G. Velikkakath, Nikhil Dev Narendradev, Aneesh Chandrasekharan, T. R. Santhoshkumar, Srinivasa M. Srinivasula
Publikováno v:
Autophagy
Mutations in the ubiquitin ligase PRKN (parkin RBR E3 ubiquitin protein ligase) are associated with Parkinson disease and defective mitophagy. Conceptually, PRKN-dependent mitophagy is classified into two phases: 1. PRKN recruits to and ubiquitinates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de840417a638906435b027eab10742f
https://europepmc.org/articles/PMC9673925/
https://europepmc.org/articles/PMC9673925/
Autor:
Aneesh Chandrasekharan, Santhik Subhasingh Lupitha, Shankara Narayanan Varadarajan, Minsa Mini, T.R. Santhoshkumar, Aparna Geetha Jayaprasad, Leena Chandrasekhar, Sanoj Namdev Patil, Prakash Rajappan Pillai
Publikováno v:
Toxicology Letters. 326:23-30
Simultaneous detection of autophagy and apoptosis is important in drug discovery and signaling studies. Here we report, a real-time reporter cell line for the simultaneous detection of apoptosis and autophagy at single-cell level employing stable int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f83807c6764ec33e776034c4760c252
https://doi.org/10.1016/j.toxlet.2020.02.011
https://doi.org/10.1016/j.toxlet.2020.02.011
Publikováno v:
J Biol Chem
Formation of a single new centriole from a pre-existing centriole is strictly controlled to maintain correct centrosome number and spindle polarity in cells. However, the mechanisms that govern this process are incompletely understood. Here, using se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa1177e2ca5a4e69b5590a7137e42fd
https://doi.org/10.1074/jbc.ac119.012178
https://doi.org/10.1074/jbc.ac119.012178
Autor:
Soumya Jaya Divakaran, Pramod Darvin, Shijulal Nelson-Sathi, M. Radhakrishna Pillai, Aneesh Chandrasekharan, Shanakara Narayanan Varadarajan, Santhik Subhasingh Lupitha, T.R. Santhoshkumar, Sreekumar Easwaran, Iype Joseph, Sara Jones, Perunthottathu K Umasankar
Quantitative determination of neutralizing antibodies against Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) is paramount in immunodiagnostics, vaccine efficacy testing, and immune response profiling among the vaccinated population. Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ffc8a61c58bfb64de97196eb4ff54a3
https://doi.org/10.1101/2021.10.13.464050
https://doi.org/10.1101/2021.10.13.464050
Publikováno v:
Cellular Oncology. 42:645-661
Anastasis is newly discovered process by which cells recover from late-stage apoptosis upon removal of a death stimulus. Recent reports suggest that cells may recover, even after the initiation of mitochondrial outer-membrane permeabilization (MOMP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a110133cb907da0f4d4ecb4a48ad195d
https://doi.org/10.1007/s13402-019-00451-1
https://doi.org/10.1007/s13402-019-00451-1