Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Aneesh, Chandran"'
Autor:
Martina Milighetti, Yanchun Peng, Cedric Tan, Michal Mark, Gayathri Nageswaran, Suzanne Byrne, Tahel Ronel, Tom Peacock, Andreas Mayer, Aneesh Chandran, Joshua Rosenheim, Matthew Whelan, Xuan Yao, Guihai Liu, Suet Ling Felce, Tao Dong, Alexander J. Mentzer, Julian C. Knight, Francois Balloux, Erez Greenstein, Shlomit Reich-Zeliger, Corinna Pade, Joseph M. Gibbons, Amanda Semper, Tim Brooks, Ashley Otter, Daniel M. Altmann, Rosemary J. Boyton, Mala K. Maini, Aine McKnight, Charlotte Manisty, Thomas A. Treibel, James C. Moon, Mahdad Noursadeghi, Benny Chain
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106937- (2023)
Summary: T cell responses precede antibody and may provide early control of infection. We analyzed the clonal basis of this rapid response following SARS-COV-2 infection. We applied T cell receptor (TCR) sequencing to define the trajectories of indiv
Externí odkaz:
https://doaj.org/article/a3d7eacf94e249aeb9cbbd5c5378f753
Autor:
Ivan Doykov, Tomas Baldwin, Justyna Spiewak, Kimberly C. Gilmour, Joseph M. Gibbons, Corinna Pade, Catherine J. Reynolds, Áine McKnight, Mahdad Noursadeghi, Mala K. Maini, Charlotte Manisty, Thomas Treibel, Gabriella Captur, Marianna Fontana, Rosemary J. Boyton, Daniel M. Altmann, Tim Brooks, Amanda Semper, James C. Moon, Kevin Mills, Wendy E. Heywood, Hakam Abbass, Aderonke Abiodun, Mashael Alfarih, Zoe Alldis, Oliver E. Amin, Mervyn Andiapen, Jessica Artico, João B. Augusto, Georgina L. Baca, Sasha N.L. Bailey, Anish N. Bhuva, Alex Boulter, Ruth Bowles, Olivia V. Bracken, Ben O’Brien, Natalie Bullock, David K. Butler, Olivia Carr, Nicola Champion, Carmen Chan, Aneesh Chandran, Tom Coleman, Jorge Couto de Sousa, Xose Couto-Parada, Eleanor Cross, Teresa Cutino-Moguel, Silvia D’Arcangelo, Rhodri H. Davies, Brooke Douglas, Cecilia Di Genova, Keenan Dieobi-Anene, Mariana O. Diniz, Anaya Ellis, Karen Feehan, Malcolm Finlay, Nasim Forooghi, Sasha Francis, David Gillespie, Derek Gilroy, Matt Hamblin, Gabrielle Harker, Georgia Hemingway, Jacqueline Hewson, Wendy Heywood, Lauren M. Hickling, Bethany Hicks, Aroon D. Hingorani, Lee Howes, Ivie Itua, Victor Jardim, Wing-Yiu Jason Lee, Melaniepetra Jensen, Jessica Jones, Meleri Jones, George Joy, Vikas Kapil, Caoimhe Kelly, Hibba Kurdi, Jonathan Lambourne, Kai-Min Lin, Siyi Liu, Aaron Lloyd, Sarah Louth, Vineela Mandadapu, Katia Menacho, Celina Mfuko, Sebastian Millward, Oliver Mitchelmore, Christopher Moon, James Moon, Diana Muñoz Sandoval, Sam M. Murray, Ashley Otter, Susana Palma, Ruth Parker, Kush Patel, Mihaela Pawarova, Steffen E. Petersen, Brian Piniera, Franziska P. Pieper, Lisa Rannigan, Alicja Rapala, Amy Richards, Matthew Robathan, Joshua Rosenheim, Cathy Rowe, Matthew Royds, Jane Sackville West, Genine Sambile, Nathalie M. Schmidt, Hannah Selman, Andreas Seraphim, Mihaela Simion, Angelique Smit, Michelle Sugimoto, Leo Swadling, Stephen Taylor, Nigel Temperton, Stephen Thomas, George D. Thornton, Thomas A. Treibel, Art Tucker, Ann Varghese, Jessry Veerapen, Mohit Vijayakumar, Tim Warner, Sophie Welch, Hannah White, Theresa Wodehouse, Lucinda Wynne, Dan Zahedi
Publikováno v:
Cell Reports: Methods, Vol 2, Iss 9, Pp 100279- (2022)
Summary: Determining the protection an individual has to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VoCs) is crucial for future immune surveillance, vaccine development, and understanding of the changing immune
Externí odkaz:
https://doaj.org/article/9be530f264774b93a8869c019914391d
Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology
Autor:
Rameen Shakur, Juan Pablo Ochoa, Alan J. Robinson, Abhishek Niroula, Aneesh Chandran, Taufiq Rahman, Mauno Vihinen, Lorenzo Monserrat
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract The cardiac troponin T variations have often been used as an example of the application of clinical genotyping for prognostication and risk stratification measures for the management of patients with a family history of sudden cardiac death
Externí odkaz:
https://doaj.org/article/d83b655e70d2430db526ecf35be2769f
Autor:
Tom A. Mendum, Aneesh Chandran, Kerstin Williams, H. Martin Vordermeier, Bernardo Villarreal-Ramos, H. Wu, Albel Singh, Alex A. Smith, Rachel E. Butler, Aravind Prasad, Neeraj Bharti, Ruma Banerjee, Sunitha M. Kasibhatla, Apoorva Bhatt, Graham R. Stewart, Johnjoe McFadden
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background BCG is the most widely used vaccine of all time and remains the only licensed vaccine for use against tuberculosis in humans. BCG also protects other species such as cattle against tuberculosis, but due to its incompatibility with
Externí odkaz:
https://doaj.org/article/faa5bbfd9bdf4147b30d7a1e6daf6243
Autor:
Yogeshwar Devarakonda, M. V. N. Janaradhan Reddy, R. S. Neethu, Aneesh Chandran, Kirtimaan Syal
Publikováno v:
Journal of Biomolecular Structure and Dynamics. :1-14
Autor:
Zdeněk Dvořák, Felix Kopp, Cait M Costello, Jazmin S Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U Nordstroem, Chamini V Karunaratne, Harmit S Ranhotra, Kyu Shik Mun, Anjaparavanda P Naren, Iain A Murray, Gary H Perdew, Julius Brtko, Lucia Toporova, Arne Schön, Bret D Wallace, William G Walton, Matthew R Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L Flannigan, Simon A Hirota, Ryan Balfour Sartor, Sridhar Mani
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp n/a-n/a (2020)
Abstract The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that esta
Externí odkaz:
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
Autor:
Kodye L. Abbott, Julia M. Salamat, Patrick C. Flannery, Chloe S. Chaudhury, Aneesh Chandran, Saraswathi Vishveshwara, Sridhar Mani, Jianfeng Huang, Amit K. Tiwari, Satyanarayana R. Pondugula
Publikováno v:
ACS Omega. 7:34034-34044
During multidrug combination chemotherapy, activation of the nuclear receptor and the transcription factor human pregnane xenobiotic receptor (hPXR) has been shown to play a role in the development of chemoresistance. Mechanistically, this could occu
Autor:
Barbora Vyhlídalová, Kristýna Krasulová, Petra Pečinková, Karolína Poulíková, Radim Vrzal, Zdeněk Andrysík, Aneesh Chandran, Sridhar Mani, Zdenek Dvorak
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8, p 2799 (2020)
The efforts for therapeutic targeting of the aryl hydrocarbon receptor (AhR) have emerged in recent years. We investigated the effects of available antimigraine triptan drugs, having an indole core in their structure, on AhR signaling in human hepati
Externí odkaz:
https://doaj.org/article/ac689271d9844133b2b83826c653b209
Autor:
Sally Forrest, Julie Demaret, Tenagnework Abozen, Begna Tulu, Jonathan Mayito, Metasebia Tegegn, Stephen T Reece, Abraham Aseffa, Emawayish A. Tirfie, Hana Manwandu, Dawit Tayachew, Denise M. O'Sullivan, Adrian R. Martineau, Kathryn A. Harris, Aboma Zewude, Gobena Ameni, Martin Vordermeier, Jim F. Huggett, Gerwyn M. Jones, Taye Tolera Balcha, Stefan Berg, Mulugeta Belay, Aneesh Chandran, Markos Abebe, Sidra Younis, Vlad Nikolayevskyy, Henny M. Martineau, Mahdad Noursadeghi, David A. Jolliffe
Publikováno v:
The Lancet. Microbe
Summary Background Haematopoietic stem cells expressing the CD34 surface marker have been posited as a niche for Mycobacterium tuberculosis complex bacilli during latent tuberculosis infection. Our aim was to determine whether M tuberculosis complex
Autor:
Catherine J, Reynolds, Corinna, Pade, Joseph M, Gibbons, Ashley D, Otter, Kai-Min, Lin, Diana, Muñoz Sandoval, Franziska P, Pieper, David K, Butler, Siyi, Liu, George, Joy, Nasim, Forooghi, Thomas A, Treibel, Charlotte, Manisty, James C, Moon, Amanda, Semper, Tim, Brooks, Áine, McKnight, Daniel M, Altmann, Rosemary J, Boyton, Hakam, Abbass, Aderonke, Abiodun, Mashael, Alfarih, Zoe, Alldis, Oliver E, Amin, Mervyn, Andiapen, Jessica, Artico, João B, Augusto, Georgina L, Baca, Sasha N L, Bailey, Anish N, Bhuva, Alex, Boulter, Ruth, Bowles, Olivia V, Bracken, Ben, O'Brien, Natalie, Bullock, Gabriella, Captur, Olivia, Carr, Nicola, Champion, Carmen, Chan, Aneesh, Chandran, Tom, Coleman, Jorge, Couto de Sousa, Xose, Couto-Parada, Eleanor, Cross, Teresa, Cutino-Moguel, Silvia, D'Arcangelo, Rhodri H, Davies, Brooke, Douglas, Cecilia, Di Genova, Keenan, Dieobi-Anene, Mariana O, Diniz, Anaya, Ellis, Karen, Feehan, Malcolm, Finlay, Marianna, Fontana, Sasha, Francis, David, Gillespie, Derek, Gilroy, Matt, Hamblin, Gabrielle, Harker, Georgia, Hemingway, Jacqueline, Hewson, Wendy, Heywood, Lauren M, Hickling, Bethany, Hicks, Aroon D, Hingorani, Lee, Howes, Ivie, Itua, Victor, Jardim, Wing-Yiu Jason, Lee, Melaniepetra, Jensen, Jessica, Jones, Meleri, Jones, Vikas, Kapil, Caoimhe, Kelly, Hibba, Kurdi, Jonathan, Lambourne, Aaron, Lloyd, Sarah, Louth, Mala K, Maini, Vineela, Mandadapu, Katia, Menacho, Celina, Mfuko, Kevin, Mills, Sebastian, Millward, Oliver, Mitchelmore, Christopher, Moon, James, Moon, Sam M, Murray, Mahdad, Noursadeghi, Ashley, Otter, Susana, Palma, Ruth, Parker, Kush, Patel, Mihaela, Pawarova, Steffen E, Petersen, Brian, Piniera, Lisa, Rannigan, Alicja, Rapala, Amy, Richards, Matthew, Robathan, Joshua, Rosenheim, Cathy, Rowe, Matthew, Royds, Jane, Sackville West, Genine, Sambile, Nathalie M, Schmidt, Hannah, Selman, Andreas, Seraphim, Mihaela, Simion, Angelique, Smit, Michelle, Sugimoto, Leo, Swadling, Stephen, Taylor, Nigel, Temperton, Stephen, Thomas, George D, Thornton, Art, Tucker, Ann, Varghese, Jessry, Veerapen, Mohit, Vijayakumar, Tim, Warner, Sophie, Welch, Hannah, White, Theresa, Wodehouse, Lucinda, Wynne, Dan, Zahedi, Benjamin, Chain
Publikováno v:
Science (New York, N.Y.). 377(6603)
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show p