Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Aneesa Amar"'
Autor:
Alan J. Kraker, Charles W. Moore, Barvian Mark Robert, Brian G. Hartl, H. D. Hollis Showalter, Aneesa Amar
Publikováno v:
Biochemical Pharmacology. 60:885-898
Increased expression or activity of c-Src tyrosine kinase has been associated with the transformed phenotype in tumor cells and with progression of neoplastic disease. A number of pyrido[2, 3-d]pyrimidines have been characterized biochemically and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9124c7855e894eaa5e692f9de06815b7
https://doi.org/10.1016/s0006-2952(00)00405-6
https://doi.org/10.1016/s0006-2952(00)00405-6
Autor:
Aneesa Amar, Gina H. Lu, Alan J. Kraker, H. D. Hollis Showalter, James Marino Hamby, Barvian Mark Robert, Brian G. Hartl, Robert L. Panek
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2903-2908
Fibroblast growth factor receptor (FGFr) mediated signal transduction is implicated in vascular proliferative diseases and some cancers. We have identified methyl 1-oxo-3-phenyl-1H-indene-2-carboxylic ester as a small molecule inhibitor of the tyrosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25cbbf66eab9272afd6be54069fec679
https://doi.org/10.1016/s0960-894x(97)10110-x
https://doi.org/10.1016/s0960-894x(97)10110-x
Autor:
Wayne D. Klohs, James Marino Hamby, Alan J. Kraker, David W. Fry, Cindy Shen, Aneesa Amar, Robert L. Panek, Gina H. Lu, Barvian Mark Robert, Connolly Cleo, Mel C. Schroeder, Annette Marian Doherty
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2415-2420
The inhibition of tyrosine kinase-mediated signal transduction pathways represents a therapeutic approach to the intervention of proliferative diseases such as cancer, atherosclerosis, and restenosis. A novel series of pyrido[2,3-d]pyrimidine inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9bb0b58520cb32a1bc8a539ccb0b14e
https://doi.org/10.1016/s0960-894x(97)00445-9
https://doi.org/10.1016/s0960-894x(97)00445-9
Autor:
Alan J. Kraker, Brian G. Hartl, Gina H. Lu, James Marino Hamby, H. D. Hollis Showalter, Aneesa Amar, Robert L. Panek, Barvian Mark Robert
Publikováno v:
ChemInform. 29
Fibroblast growth factor receptor (FGFr) mediated signal transduction is implicated in vascular proliferative diseases and some cancers. We have identified methyl 1-oxo-3-phenyl-1H-indene-2-carboxylic ester as a small molecule inhibitor of the tyrosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f0f7e7cd5355b6b23e6ee67041af8b7
https://doi.org/10.1002/chin.199810112
https://doi.org/10.1002/chin.199810112
Autor:
Joan A. Keiser, Tawny K. Dahring, Mel C. Schroeder, and Hussein Hallak, David W. Fry, H. D. Hollis Showalter, James Marino Hamby, Aneesa Amar, Alan J. Kraker, Gina H. Lu, R. Thomas Winters, C. J. C. Connolly, Cindy Shen, James M. Nelson, Annette Marian Doherty, Michael J. Ryan, T C Major, Laura A. Bradford, Veronika Slintak, Bronislawa Olsewski, Robert L. Panek
Publikováno v:
Journal of medicinal chemistry. 40(15)
Screening of a compound library for inhibitors of the fibroblast growth factor (FGFr) and platelet-derived growth factor (PDGFr) receptor tyrosine kinases led to the development of a novel series of ATP competitive pyrido[2,3-d]pyrimidine tyrosine ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb64308444b49cda43326bd277026e85
https://pubmed.ncbi.nlm.nih.gov/9240345
https://pubmed.ncbi.nlm.nih.gov/9240345