Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Aneel K. Aggarwal"'
Autor:
Richard Quintana-Feliciano, Jithesh Kottur, Mi Ni, Rikhia Ghosh, Leslie Salas-Estrada, Goran Ahlsen, Olga Rechkoblit, Lawrence Shapiro, Marta Filizola, Gang Fang, Aneel K. Aggarwal
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Burkholderia cenocepacia is an opportunistic and infective bacterium containing an orphan DNA methyltransferase called M.BceJIV with roles in regulating gene expression and motility of the bacterium. M.BceJIV recognizes a GTWWAC motif (where
Externí odkaz:
https://doaj.org/article/2beb0819c5a6441cae69edcef87014d6
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract A short prokaryotic Argonaute (pAgo) TIR-APAZ (SPARTA) defense system, activated by invading DNA to unleash its TIR domain for NAD(P)+ hydrolysis, was recently identified in bacteria. We report the crystal structure of SPARTA heterodimer in
Externí odkaz:
https://doaj.org/article/57968ffefe0f44f0949c9b5470ea0324
Autor:
Radhika Malik, Robert E. Johnson, Louise Prakash, Satya Prakash, Iban Ubarretxena-Belandia, Aneel K. Aggarwal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-6 (2022)
The structure of mismatched DNA-Polζ ternary complex provides a basis for understanding what makes Polζ adept at extending DNA synthesis past mismatched base pairs.
Externí odkaz:
https://doaj.org/article/f26c65399068427e98751e9f37644e54
Autor:
Katsutoshi Sato, Amol A. Padgaonkar, Stacey J. Baker, Stephen C. Cosenza, Olga Rechkoblit, D. R. C. Venkata Subbaiah, Josep Domingo-Domenech, Alison Bartkowski, Elisa R. Port, Aneel K. Aggarwal, M. V. Ramana Reddy, Hanna Y. Irie, E. Premkumar Reddy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Finding therapeutic strategies for aggressive triple negative breast cancer (TNBC) is an important challenge in clinical practice. Here, the authors identify a multi-kinases inhibitor with antitumor activity and able overcome chemotherapy resistance
Externí odkaz:
https://doaj.org/article/72cb347eb0744a6cbe886fef6ee09227
Autor:
Olga Rechkoblit, Robert E. Johnson, Yogesh K. Gupta, Louise Prakash, Satya Prakash, Aneel K. Aggarwal
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The human DNA primase and DNA polymerase PrimPol replicates through the major oxidative DNA damage lesion 7,8-dihydro-8-oxoguanine (oxoG) via translesion synthesis in a mostly error-free manner thus suppressing oxoG-induced mutagenesis in mitochondri
Externí odkaz:
https://doaj.org/article/773f625abe814094998cc661e3a4cdba
Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine
Autor:
Olga Rechkoblit, Jayati Roy Choudhury, Angeliki Buku, Louise Prakash, Satya Prakash, Aneel K. Aggarwal
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Cytarabine (AraC) is an essential chemotherapeutic for acute myeloid leukemia (AML) and resistance to this drug is a major cause of treatment failure. AraC is a nucleoside analog that differs from 2′-deoxycytidine only by the presence of a
Externí odkaz:
https://doaj.org/article/fc4ac48cac464dccbd0b27802d40046f
Autor:
Olga Rechkoblit, Alexander Kolbanovskiy, Hannah Landes, Nicholas E. Geacintov, Aneel K. Aggarwal
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Benzo[a]pyrene (BP) is a carcinogen in cigarette smoke that upon metabolic activation reacts with guanine. Here, the authors present the structures of the translesion DNA synthesis polymerase Rev1 in complex with three of the four possible stereoisom
Externí odkaz:
https://doaj.org/article/7dfd4600623948c893925d6ff8837886
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract The Zika virus (ZIKV) has emerged as a major health hazard. We present here a high resolution structure (1.55 Å) of ZIKV NS5 methyltransferase bound to a novel S-adenosylmethionine (SAM) analog in which a 4-fluorophenyl moiety substitutes f
Externí odkaz:
https://doaj.org/article/8868ec6242b34c468df4cb1b113ec0bd
Autor:
Javier Coloma, Rinku Jain, Kanagalaghatta R. Rajashankar, Adolfo García-Sastre, Aneel K. Aggarwal
Publikováno v:
Cell Reports, Vol 16, Iss 12, Pp 3097-3102 (2016)
The Zika virus (ZIKV) poses a major public health emergency. To aid in the development of antivirals, we present two high-resolution crystal structures of the ZIKV NS5 methyltransferase: one bound to S-adenosylmethionine (SAM) and the other bound to
Externí odkaz:
https://doaj.org/article/7203aab7b6264402a3b0659cda43a5e2
Autor:
Yacob Gómez-Llorente, Radhika Malik, Rinku Jain, Jayati Roy Choudhury, Robert E. Johnson, Louise Prakash, Satya Prakash, Iban Ubarretxena-Belandia, Aneel K. Aggarwal
Publikováno v:
Cell Reports, Vol 5, Iss 1, Pp 79-86 (2013)
DNA polymerase ζ (Polζ) is specialized for the extension step of translesion DNA synthesis (TLS). Despite its central role in maintaining genome integrity, little is known about its overall architecture. Initially identified as a heterodimer of the
Externí odkaz:
https://doaj.org/article/b39f9dfc3c174090be184bc530b8c145