Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Andy Z X Zhu"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 7, p e1009715 (2022)
Bispecific T cell engagers (TCEs) are an emerging anti-cancer modality that redirects cytotoxic T cells to tumor cells expressing tumor-associated antigens (TAAs), thereby forming immune synapses to exert anti-tumor effects. Designing pharmacokinetic
Externí odkaz:
https://doaj.org/article/6aea3f06713f4fb38c4539558cf0b7da
Autor:
Andrew W Bergen, Martha Michel, Denise Nishita, Ruth Krasnow, Harold S Javitz, Karen N Conneely, Christina N Lessov-Schlaggar, Hyman Hops, Andy Z X Zhu, James W Baurley, Jennifer B McClure, Sharon M Hall, Timothy B Baker, David V Conti, Neal L Benowitz, Caryn Lerman, Rachel F Tyndale, Gary E Swan, Transdisciplinary Research in Cancer of the Lung Research Team
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0126113 (2015)
The Nicotine Metabolite Ratio (NMR, ratio of trans-3'-hydroxycotinine and cotinine), has previously been associated with CYP2A6 activity, response to smoking cessation treatments, and cigarette consumption. We searched for drug metabolizing enzyme an
Externí odkaz:
https://doaj.org/article/482e4745ab7b45ce912e61d8e8237ff7
Autor:
Rachel F Tyndale, Andy Z X Zhu, Tony P George, Paul Cinciripini, Larry W Hawk, Robert A Schnoll, Gary E Swan, Neal L Benowitz, Daniel F Heitjan, Caryn Lerman, PGRN-PNAT Research Group
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128109 (2015)
CHRNA5-A3-B4 variants, rs16969968, rs588765 and rs578776, are consistently associated with tobacco consumption among smokers, but the association with smoking cessation is less consistent. Among the studies that reported significant associations with
Externí odkaz:
https://doaj.org/article/08ad16306e92446085e4a3ce871ff0e8
Autor:
Shakir D Alsharari, Justin R King, Jacob C Nordman, Pretal P Muldoon, Asti Jackson, Andy Z X Zhu, Rachel F Tyndale, Nadine Kabbani, M Imad Damaj
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137070 (2015)
Although menthol, a common flavoring additive to cigarettes, has been found to impact the addictive properties of nicotine cigarettes in smokers little is known about its pharmacological and molecular actions in the brain. Studies were undertaken to
Externí odkaz:
https://doaj.org/article/1bec6611c1144482a1b52f86266bcd64
Autor:
Andy Z X Zhu, Qian Zhou, Lisa Sanderson Cox, Jasjit S Ahluwalia, Neal L Benowitz, Rachel F Tyndale
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70938 (2013)
CYP2A6 metabolizes nicotine to its primary metabolite cotinine and also mediates the metabolism of cotinine to trans-3'-hydroxycotinine (3HC). The ratio of 3HC to cotinine (the "nicotine metabolite ratio", NMR) is an in vivo marker for the rate of CY
Externí odkaz:
https://doaj.org/article/b01d5c7dac6d4ba387c9271b14a1c3d0
Autor:
Bhagwat Prasad, Ahmed El-Boraie, Rachel F. Tyndale, Kenneth E. Thummel, Caryn Lerman, Katrina G. Claw, Julie-Anne Tanner, Koya Fukunaga, Taisei Mushiroda, Michiaki Kubo, Neal L. Benowitz, Andy Z. X. Zhu, Erin G. Schuetz
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 15, Iss 1, Pp 204-220 (2022)
Clinical and translational science, vol 15, iss 1
Clinical and Translational Science, Vol 15, Iss 1, Pp 204-220 (2022)
Clinical and translational science, vol 15, iss 1
CYP2A6 activity, phenotyped by the nicotine metabolite ratio (NMR), is a predictor of several smoking behaviors, including cessation and smoking‐related disease risk. The heritability of the NMR is 60–80%, yet weighted genetic risk scores (wGRSs)
Autor:
Neal L. Benowitz, Jo Knight, Annie R. Peng, Andy Z. X. Zhu, Lisa Sanderson Cox, Meghan J. Chenoweth, Nikki Nollen, Walter Swardfager, Jasjit S. Ahluwalia, Rachel F. Tyndale
BACKGROUND AND AIMS: CYP2B6, a genetically variable enzyme, converts bupropion to its active metabolite hydroxybupropion. CYP2B6 activity and bupropion-aided cessation differ between women and men. The aim of this study was to determine whether genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1aa11bb6b97af5e2acfa7bfc670649c
https://doi.org/10.1111/add.15742
https://doi.org/10.1111/add.15742
Autor:
Guoying Tai, Pradeep Sharma, Vijay V. Upreti, Jun Chen, Sheila Annie Peters, Andy Z. X. Zhu, Ying-Hong Wang, Susanna Tse, Tycho Heimbach, Binfeng Xia, Ming Zheng, Italo Poggesi, Vaishali Dixit, Alice Tsai, Mohamad Shebley, Stephen D. Hall, Yuan Chen, Neil Parrott, Jan Snoeys
Publikováno v:
Clinical Pharmacology and Therapeutics
The predictive performance of physiologically‐based pharmacokinetics (PBPK) models for pharmacokinetics (PK) in renal impairment (RI) and hepatic impairment (HI) populations was evaluated using clinical data from 29 compounds with 106 organ impairm
Autor:
Andy Z X, Zhu, Mark, Rogge
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2486
Significant advances in analytical technologies have dramatically improved our ability to deconvolute disease biology at molecular, cellular, and tissue levels. Quantitative system pharmacology (QSP) modeling is a computational framework to systemati
Autor:
Bradley Stringer, Kurt Eng, Katharine C. Lai, Mark G. Qian, Jennifer Fretland, Melissa Gallery, Robbie Robertson, Melissa Saylor Landen, Cindy Q. Xia, Adnan O. Abu-Yousif, O. Petter Veiby, Afrand Kamali, Maria Borland, Secil Koseoglu, Bret Bannerman, Andy Z. X. Zhu, Michelle L. Ganno, Thomas A. Keating, Michael D. Smith, Donna Cvet, Jayaprakasam Bolleddula
Publikováno v:
Molecular Cancer Therapeutics. 19:2079-2088
Guanylyl cyclase C (GCC) is a unique therapeutic target with expression restricted to the apical side of epithelial cell tight junctions thought to be only accessible by intravenously administered agents on malignant tissues where GCC expression is a