Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Andy Z X Zhu"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 7, p e1009715 (2022)
Bispecific T cell engagers (TCEs) are an emerging anti-cancer modality that redirects cytotoxic T cells to tumor cells expressing tumor-associated antigens (TAAs), thereby forming immune synapses to exert anti-tumor effects. Designing pharmacokinetic
Externí odkaz:
https://doaj.org/article/6aea3f06713f4fb38c4539558cf0b7da
Autor:
Bhagwat Prasad, Ahmed El-Boraie, Rachel F. Tyndale, Kenneth E. Thummel, Caryn Lerman, Katrina G. Claw, Julie-Anne Tanner, Koya Fukunaga, Taisei Mushiroda, Michiaki Kubo, Neal L. Benowitz, Andy Z. X. Zhu, Erin G. Schuetz
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 15, Iss 1, Pp 204-220 (2022)
Clinical and translational science, vol 15, iss 1
Clinical and Translational Science, Vol 15, Iss 1, Pp 204-220 (2022)
Clinical and translational science, vol 15, iss 1
CYP2A6 activity, phenotyped by the nicotine metabolite ratio (NMR), is a predictor of several smoking behaviors, including cessation and smoking‐related disease risk. The heritability of the NMR is 60–80%, yet weighted genetic risk scores (wGRSs)
Autor:
Neal L. Benowitz, Jo Knight, Annie R. Peng, Andy Z. X. Zhu, Lisa Sanderson Cox, Meghan J. Chenoweth, Nikki Nollen, Walter Swardfager, Jasjit S. Ahluwalia, Rachel F. Tyndale
BACKGROUND AND AIMS: CYP2B6, a genetically variable enzyme, converts bupropion to its active metabolite hydroxybupropion. CYP2B6 activity and bupropion-aided cessation differ between women and men. The aim of this study was to determine whether genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1aa11bb6b97af5e2acfa7bfc670649c
https://doi.org/10.1111/add.15742
https://doi.org/10.1111/add.15742
Autor:
Lois S. Akinola, Bryan Mckiver, Wisam Toma, Andy Z. X. Zhu, Rachel F. Tyndale, Vivek Kumar, M. Imad Damaj
Publikováno v:
Brain Sciences, Vol 9, Iss 10, p 244 (2019)
Tobacco smoking is the major cause of disability and death in the United States and around the world. In addition, tobacco dependence and addiction express themselves as complex behaviors involving an interplay of genetics, environment, and psycholog
Externí odkaz:
https://doaj.org/article/b9d0931229e644429e93157d8d94d467
Autor:
Guoying Tai, Pradeep Sharma, Vijay V. Upreti, Jun Chen, Sheila Annie Peters, Andy Z. X. Zhu, Ying-Hong Wang, Susanna Tse, Tycho Heimbach, Binfeng Xia, Ming Zheng, Italo Poggesi, Vaishali Dixit, Alice Tsai, Mohamad Shebley, Stephen D. Hall, Yuan Chen, Neil Parrott, Jan Snoeys
Publikováno v:
Clinical Pharmacology and Therapeutics
The predictive performance of physiologically‐based pharmacokinetics (PBPK) models for pharmacokinetics (PK) in renal impairment (RI) and hepatic impairment (HI) populations was evaluated using clinical data from 29 compounds with 106 organ impairm
Autor:
Andy Z X, Zhu, Mark, Rogge
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2486
Significant advances in analytical technologies have dramatically improved our ability to deconvolute disease biology at molecular, cellular, and tissue levels. Quantitative system pharmacology (QSP) modeling is a computational framework to systemati
Autor:
Bradley Stringer, Kurt Eng, Katharine C. Lai, Mark G. Qian, Jennifer Fretland, Melissa Gallery, Robbie Robertson, Melissa Saylor Landen, Cindy Q. Xia, Adnan O. Abu-Yousif, O. Petter Veiby, Afrand Kamali, Maria Borland, Secil Koseoglu, Bret Bannerman, Andy Z. X. Zhu, Michelle L. Ganno, Thomas A. Keating, Michael D. Smith, Donna Cvet, Jayaprakasam Bolleddula
Publikováno v:
Molecular Cancer Therapeutics. 19:2079-2088
Guanylyl cyclase C (GCC) is a unique therapeutic target with expression restricted to the apical side of epithelial cell tight junctions thought to be only accessible by intravenously administered agents on malignant tissues where GCC expression is a
Autor:
Andy Z. X. Zhu, Mark Rogge
Publikováno v:
Methods in Molecular Biology ISBN: 9781071622643
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27677b6e27d106cc7081b7a14873fa4e
https://doi.org/10.1007/978-1-0716-2265-0_5
https://doi.org/10.1007/978-1-0716-2265-0_5
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 12, Pp 951-961 (2019)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
Gastrointestinal (GI)-related adverse events (AEs) are commonly observed in the clinic during cancer treatments. Citrulline is a potentially translatable biomarker of GI AEs. In this study, irinotecan-induced citrulline changes were studied for a ran
Autor:
Andrew W Bergen, Martha Michel, Denise Nishita, Ruth Krasnow, Harold S Javitz, Karen N Conneely, Christina N Lessov-Schlaggar, Hyman Hops, Andy Z X Zhu, James W Baurley, Jennifer B McClure, Sharon M Hall, Timothy B Baker, David V Conti, Neal L Benowitz, Caryn Lerman, Rachel F Tyndale, Gary E Swan, Transdisciplinary Research in Cancer of the Lung Research Team
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0126113 (2015)
The Nicotine Metabolite Ratio (NMR, ratio of trans-3'-hydroxycotinine and cotinine), has previously been associated with CYP2A6 activity, response to smoking cessation treatments, and cigarette consumption. We searched for drug metabolizing enzyme an
Externí odkaz:
https://doaj.org/article/482e4745ab7b45ce912e61d8e8237ff7