Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling

Autor: Matti A. Hiob, Pascal Bernatchez, Tanya Uy, Andy Trane, Dmitri Pavlov

Publikováno v: European Journal of Pharmacology. 766:46-55

Caveolin-1 (Cav-1), the homo-oligomeric coat protein of cholesterol-rich caveolae signalosomes, regulates signaling proteins including endothelial nitric oxide synthase (eNOS). The Cav-1 scaffolding domain (a.a. 82-101) inhibits activated eNOS from p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39bcc9911393c1f668be890bf51dd9b
https://doi.org/10.1016/j.ejphar.2015.09.033

Amlodipine increases endothelial nitric oxide release by modulating binding of native eNOS protein complex to caveolin-1

Autor: Arpeeta Sharma, Pascal Bernatchez, Carol Yu, Jean-Francois Jasmin, Andy Trane

Publikováno v: European Journal of Pharmacology. 659:206-212

Amongst calcium channel blockers, amlodipine is known to have unique cardioprotective activities likely attributable to its capacity to increase nitric oxide (NO) release from endothelial cells (EC). Because endothelial NO synthase (eNOS), the main s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d80d2b113affdad0d502eff8936a2bf
https://doi.org/10.1016/j.ejphar.2011.03.028

Optimized Caveolin‐1 Scaffolding Domain‐derived peptides for increasing protective nitric oxide production in vascular diseases

Autor: Pascal Bernatchez, Andy Trane

Publikováno v: The FASEB Journal. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a11ec5a60623993b7b0f1303fbe4590
https://doi.org/10.1096/fasebj.27.1_supplement.878.1

Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition

Autor: Ayesha N. Shajahan, Randal A. Skidgel, Andy Trane, Marcelo G. Bonini, Farnaz R. Bakhshi, Tiffany Sharma, Geerten P. van Nieuw Amerongen, Zhenlong Chen, Pascal Bernatchez, Asrar B. Malik, Richard D. Minshall, Mao Mao

Publikováno v: Molecular Biology of the Cell, 23(7), 1388-1398. American Society for Cell Biology
Molecular Biology of the Cell
Chen, Z L, Bakhshi, F R, Shajahan, A N, Sharma, T, Mao, M, Trane, A, Bernatchez, P, van Nieuw Amerongen, G P, Bonini, M G, Skidgel, R A, Malik, A B & Minshall, R D 2012, ' Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition ', Molecular Biology of the Cell, vol. 23, no. 7, pp. 1388-1398 . https://doi.org/10.1091/mbc.E11-09-0811

The mechanism of caveolin-1–dependent eNOS inactivation is not clear. These studies reveal that NO-mediated Src kinase activation and caveolin-1 phosphorylation promote eNOS binding and inactivation, that is, eNOS negative feedback regulation.