Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Andy T. Merritt"'
Autor:
David A. Baker, Lindsay B. Stewart, Jonathan M. Large, Paul W. Bowyer, Keith H. Ansell, María B. Jiménez-Díaz, Majida El Bakkouri, Kristian Birchall, Koen J. Dechering, Nathalie S. Bouloc, Peter J. Coombs, David Whalley, Denise J. Harding, Ela Smiljanic-Hurley, Mary C. Wheldon, Eloise M. Walker, Johannes T. Dessens, María José Lafuente, Laura M. Sanz, Francisco-Javier Gamo, Santiago B. Ferrer, Raymond Hui, Teun Bousema, Iñigo Angulo-Barturén, Andy T. Merritt, Simon L. Croft, Winston E. Gutteridge, Catherine A. Kettleborough, Simon A. Osborne
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Protein kinases are promising drug targets for treatment of malaria. Here, starting with a medicinal chemistry approach, Baker et al. generate an imidazopyridine that selectively targets Plasmodium falciparum PKG, inhibits blood stage parasite growth
Externí odkaz:
https://doaj.org/article/0c48607312374096801bf91f077ff9c0
Publikováno v:
The Journal of Organic Chemistry. 66:3284-3290
The palladium-catalyzed reaction of pinacolone with tert-butyldimethyl(3-(2-bromophenyl)allyloxy)silane results in direct formation of 1-vinyl-3-tert-butyl-1H-isochromene. This is the result of a ketone arylation followed by an intramolecular cycliza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c672859b1d2f218dc39c75249b5f2ce
https://doi.org/10.1021/jo0011991
https://doi.org/10.1021/jo0011991
ChemInform Abstract: Palladium-Catalyzed Tandem Reactions to Form 1-Vinyl-1H-isochromene Derivatives
Publikováno v:
ChemInform. 32
The palladium-catalyzed reaction of pinacolone with tert-butyldimethyl(3-(2-bromophenyl)allyloxy)silane results in direct formation of 1-vinyl-3-tert-butyl-1H-isochromene. This is the result of a ketone arylation followed by an intramolecular cycliza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d0c94ff9fc963c502aea143293c4dc7
https://doi.org/10.1002/chin.200138133
https://doi.org/10.1002/chin.200138133
Autor:
Andy T. Merritt, Peter N. Lowe, Andrew Lockhart, Guizhu Hong, Liang Ye, Jennifer L. Morgenstern, Antony D. Gee, John Brown, Duncan B. Judd
Publikováno v:
The Journal of biological chemistry. 280(9)
Imaging the progression of Alzheimer's disease would greatly facilitate the discovery of therapeutics, and a wide range of ligands are currently under development for the detection of beta-amyloid peptide (Abeta)-containing plaques by using positron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe6a8fc2696367901ead37463ed111d
https://pubmed.ncbi.nlm.nih.gov/15615711
https://pubmed.ncbi.nlm.nih.gov/15615711
Autor:
Alastair Binnie, Stephen P Watson, Andy T Merritt, Tom H Mander, Martin J. Valler, Jane C Denyer, Darren V. S. Green, Jane A Lewis, Brian Evans, Mary C Donnelly, Brian Cox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::337f3a83b8c17bd0bc2c77eab7b7613c
https://doi.org/10.1016/s0079-6468(08)70058-4
https://doi.org/10.1016/s0079-6468(08)70058-4
Autor:
Oxford, A. W., King, Frank D.
This volume reviews recent advances in five important areas of medicinal chemistry which will be of interest both to chemists and to scientists of other disciplines engaged in medicines research and development. Included are accounts of successful dr