Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Andy T, Long"'
Autor:
Linda Labberton, Ellinor Kenne, Andy T. Long, Katrin F. Nickel, Antonio Di Gennaro, Rachel A. Rigg, James S. Hernandez, Lynn Butler, Coen Maas, Evi X. Stavrou, Thomas Renné
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The inorganic procoagulant polymer polyphosphate participates in thrombosis via factor XII. Here the authors use recombinant probes that specifically bind or degrade circulating polyphosphate to protect mice in arterial and venous thrombosis models w
Externí odkaz:
https://doaj.org/article/f48adfdce9824e40bf17559630815825
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Anaphylaxis is a life-threatening allergic reaction. It is triggered by the release of pro-inflammatory cytokines and mediators from mast cells and basophils in response to immunologic or non-immunologic mechanisms. Mediators that are released upon m
Externí odkaz:
https://doaj.org/article/7dcb1ae205af41dba06679f1f327861a
The plasma contact system, a protease cascade at the nexus of inflammation, coagulation and immunity
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1864:2118-2127
The contact system is a potent procoagulant and proinflammatory plasma protease cascade that is initiated by binding ("contact")-induced, auto-activation of factor XII zymogen. Formed active serine protease FXIIa then cleaves plasma prekallikrein to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f87360e8a3ed04220e9a69fa493ba3b
https://doi.org/10.1016/j.bbamcr.2017.07.009
https://doi.org/10.1016/j.bbamcr.2017.07.009
Autor:
Christine L.H. Snozek, Katrin F. Nickel, Evi X. Stavrou, James S Hernandez, Thomas Renné, Linda Labberton, Sandra J. Gendler, Coen Maas, Andy T. Long, Stefan Blankenberg
Publikováno v:
Cytometry Part B: Clinical Cytometry. 94:369-373
Background Platelet polyphosphate is an inorganic procoagulant polymer of orthophosphate units that is stored in dense granules and is released upon platelet activation. Here, we describe an assay to measure polyphosphate on the surface of procoagula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cf9fa1b9b29d475d56cb3cf655bce67
https://doi.org/10.1002/cyto.b.21492
https://doi.org/10.1002/cyto.b.21492
Autor:
Andy T. Long, Florian Langer, Tobias A. Fuchs, Evi X. Stavrou, Thomas Renné, Katrin F. Nickel, Linda Labberton, Lynn M. Butler
Publikováno v:
Thrombosis Research. 141:S4-S7
Cancer is an established risk factor for venous thromboembolism (VTE) and VTE is the second leading cause of death in patients with cancer. The incidence of cancer-related thrombosis is rising and is associated with worse outcomes. Despite our growin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e93e981fad173f4dd09a4639b0aafa
https://doi.org/10.1016/s0049-3848(16)30353-x
https://doi.org/10.1016/s0049-3848(16)30353-x
Autor:
Sudeh Izadmehr, Omar Alhalabi, Alvin H. Schmaier, Kara L. Bane, Anirban Sen Gupta, Agharnan Gandhi, George R. Dubyak, Cindy C. Reynolds, Andy T. Long, Alona Merkulova, Wen Mei Yu, Howard J. Meyerson, Lalitha Nayak, Clément Naudin, Michele M. Mumaw, Marvin T. Nieman, Umut A. Gurkan, Cheng-Kui Qu, Erdem Kucukal, Adina Brett-Morris, Thomas Renné, Evi X. Stavrou, Chao Fang
Coagulation factor XII (FXII) deficiency is associated with decreased neutrophil migration, but the mechanisms remain uncharacterized. Here, we examine how FXII contributes to the inflammatory response. In 2 models of sterile inflammation, FXII-defic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3612c60ec3b521e147d3fff7a7887db
https://europepmc.org/articles/PMC5824869/
https://europepmc.org/articles/PMC5824869/
Autor:
Evi X. Stavrou, F. R. Stahl, Thomas Renné, Katrin F. Nickel, Andy T. Long, Ellinor Kenne, Tobias A. Fuchs
Publikováno v:
Journal of Internal Medicine. 278:571-585
Plasma protein factor XII (FXII) activates the procoagulant and proinflammatory contact system that drives both the kallikrein-kinin system and the intrinsic pathway of coagulation. When zymogen FXII comes into contact with negatively charged surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd8ed91471430cd68dcc973ca1ce8ec
https://doi.org/10.1111/joim.12430
https://doi.org/10.1111/joim.12430
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 8 (2017)
Frontiers in Immunology, Vol 8 (2017)
Anaphylaxis is a life-threatening allergic reaction. It is triggered by the release of pro-inflammatory cytokines and mediators from mast cells and basophils in response to immunologic or non-immunologic mechanisms. Mediators that are released upon m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c28fec744abe760c66046d0b6d0862
Autor:
Stefan Kluge, Tobias A. Fuchs, Rostyslav Bilyy, Hans Georg Mannherz, Christoph Renné, Veit Krenn, Chandini Rangaswamy, Rachita Panda, Yashin J. Simsek, Josephine Bitterling, Ulf Panzer, Thomas Renné, Markus Napirei, Daisuke Kitamura, Martin Herrmann, Ryushin Mizuta, Miguel Jiménez-Alcázar, Andy T. Long
Publikováno v:
Science (New York, N.Y.). 358(6367)
Blood DNases hack the NET Neutrophil extracellular traps (NETs) are lattices of processed chromatin decorated with select secreted and cytoplasmic proteins that trap and neutralize microbes. However, their inappropriate release may do more harm than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615bf6cd9416036edafce912e0aa85e1
https://pubmed.ncbi.nlm.nih.gov/29191890
https://pubmed.ncbi.nlm.nih.gov/29191890
Autor:
Anil Singh, Baskar Nammalwar, Doris M. Benbrook, K. Darrell Berlin, Hiroyuki Matsumoto, Andy T. Long, Richard A. Bunce
Publikováno v:
Investigational New Drugs
Summary SHetA2 is a small molecule flexible heteroarotinoid (Flex-Het) with promising cancer prevention and therapeutic activity. Extensive preclinical testing documented lack of SHetA2 toxicity at doses 25 to 150 fold above effective doses. Knowledg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1dabba188b8529c37f1d87ff533854d
https://doi.org/10.1007/s10637-013-0041-x
https://doi.org/10.1007/s10637-013-0041-x