Výsledky vyhledávání - "Andy Siwkowski"

Antisense oligonucleotides: efficient synthesis of 2'-O-methoxyethyl phosphorothioate oligonucleotides using 4,5-dicyanoimidazole. Are these oligonucleotides comparable to those synthesized using 1H-tetrazole as coupling activator?

Autor: Phil Olsen, Andy Siwkowski, Vasulinga T. Ravikumar, Walt F. Lima, Zhiwei Wang

Publikováno v: Bioorganicmedicinal chemistry. 14(14)

Multiple 2'-O-methoxyethyl modified phosphorothioate oligonucleotides of 18-20-mer in length were synthesized at various scales using 4,5-dicyanoimidazole (DCI) as coupling activator. Extensive synthetic, analytical (using ion-pair LC-MS), and in viv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b319084ec3248993afc866fc0fc6c64c
https://pubmed.ncbi.nlm.nih.gov/16563772

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Antisense Oligonucletide Mediated Depletion of Factor VII Provides Protection from Ferric Chloride Induced Thrombosis without Increased Bleeding Risk in Mice

Autor: Andy Siwkowski, Brett P. Monia, Chenguang Zhao, Hong Zhang, Dacao Gao, Jeff Crosby

Publikováno v: Blood. 112:3080-3080

The Tissue Factor-Factor VIIa complex is the initiating protease in the extrinsic pathway of the coagulation cascade. Knockout of Factor VII in mice results in embryonic lethality. However, only humans with severe Factor VII deficiency exhibit any co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a9b7d91e27990959bea5c082800fd9f
https://doi.org/10.1182/blood.v112.11.3080.3080

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Selective Abrogation of STAT5 Expression Impairs the Proliferation of Acute Myeloid Leukemia Cells with Various Cytogenetic Alterations

Autor: Sanjay K. Pandey, Brett P. Monia, Donna Witchell, Tianyuan Zhou, Shuling Guo, Andy Siwkowski, Youngsoo Kim

Publikováno v: Blood. 112:5024-5024

STAT5 is a key common downstream mediator of multiple signaling pathways which are often dysregulated in various hematologic malignancies, including acute myeloid leukemia (AML). Due to the heterogeneity and high relapse rate of the disease, the trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5f5e9094cd35e2a70c16752b025de49
https://doi.org/10.1182/blood.v112.11.5024.5024

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Antithrombotic Effects of a FXI Antisense Oligonucleotide in Mice

Autor: Dacao Gao, Hong Zhang, Brett P. Monia, Curt Mazur, Susan M. Freier, Chris Black, Andy Siwkowski, Chenguang Zhao, Jeff Crosby, Andrew T. Watt

Publikováno v: Blood. 112:3076-3076

FXI, a component of the intrinsic pathway of coagulation, contributes to the generation of thrombin and is also activated by thrombin on the surface of platelets, resulting in further amplification of the coagulation process. Reports have shown that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8218bf9fdd02d365e0f7c58416121f8e
https://doi.org/10.1182/blood.v112.11.3076.3076

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Reversibility in Mice of FXI Antisense-Induced Anticoagulation by Administration of FXI Protein Concentrate or a Sense Oligonucleotide

Autor: Hong Zhang, Jeff Crosby, Chenguang Zhao, Andy Siwkowski, Brett P. Monia

Publikováno v: Blood. 112:1904-1904

Antisense drug technology is an effective approach for specifically targeting coagulation factors expressed in the liver. We have shown previously that this approach can be used to produce potent antithrombotic activity against a range of coagulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::057be9b11454e5f2b59b1dc858514332
https://doi.org/10.1182/blood.v112.11.1904.1904

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A Sense Oligonucleotide Specifically Reverses the Prothrombin Depletion and Anticoagulation Caused by ISIS 401025, an Antisense Oligonucleotide Targeting Prothrombin RNA in Mice

Autor: Andy Siwkowski, Hong Zhang, Chenguang Zhao, Donna Witchell, Sue Freier, Brett P. Monia

Publikováno v: Blood. 110:926-926

The ability to safely and effectively neutralize anticoagulant activity is of particular importance in the case of long acting drugs. While antisense oligonucleotides (ASOs) benefit from their slow clearance rate from liver (t1/2 approx 10 days in mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9ffa970c4c5ac0c820b423fe3c2c35f
https://doi.org/10.1182/blood.v110.11.926.926

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Antisense Strategies to Specifically Deplete Levels of Factors II, VII and IX in Mice To Assess Their Potential as Targets for Anticoagulation

Autor: Hong Zhang, Sue Freier, Donna Witchell, Andy Siwkowski, Jeff Crosby, Brett P. Monia, Chenguang Zhao

Publikováno v: Blood. 110:922-922

Numerous potential intervention points exist within coagulation pathways for development of novel anticoagulant agents. To help determine the most suitable target for the discovery of novel antithrombotic agents, we have implemented an antisense stra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::950abe6b38014fde231bb47c12b57e90
https://doi.org/10.1182/blood.v110.11.922.922

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