Výsledky vyhledávání

Recommendations for Specimen and Therapy Selection in Colorectal Cancer

Autor: Andy Pao, Nan Deng, Jean Lopategui, Jennelle C Hodge, Snehal B Patel, Robert Bookstein, Christian Riley, Serhan Alkan, Angela Aguiluz, Zhenqui Liu, Navid Farahani, Myriam Chevarie-Davis

Publikováno v: Oncology and Therapy

Introduction Next-generation sequencing has emerged as a clinical tool for the identification of actionable mutations to triage advanced colorectal cancer patients for targeted therapies. The literature is conflicted as to whether primaries or their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0b6d07bd6dd4295c57fe03ebb2d82e
https://doi.org/10.1007/s40487-021-00151-7

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Comparison of Large, Medium, and Small Solid Tumor Gene Panels for Detection of Clinically Actionable Mutations in Cancer

Autor: Serhan Alkan, Robert A. Figlin, David M. Engman, Jing Xu, Monica M. Mita, Jean Lopategui, Eric Vail, Andy Pao, Wenjuan Zhang, Rhona Schreck, Alain C. Mita, Joseph Frye, Angela Aguiluz, Jianbo Song, Jong Taek Kim

Publikováno v: Targeted Oncology. 15:523-530

Next-generation sequencing of gene panels has supplanted single-gene testing for cancer molecular diagnostics in many laboratories. Considerations for the optimal number of genes to assess in a panel depend on the purpose of the testing. To address t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7465172d6ce1d6645a4cd8cf40132b06
https://doi.org/10.1007/s11523-020-00743-9

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Next-Generation Sequencing

Autor: Nan Deng, Jean Lopategui, Ann E. Walts, Andy Pao, Snehal B Patel, Angela Aguiluz, Alberto M. Marchevsky, Zhenqui Liu, Tudor Mudalige, Wendy Kadi

Publikováno v: The Journal of Molecular Diagnostics. 19:870-880

Distinguishing between multiple lung primary tumors and intrapulmonary metastases is imperative for accurate staging. The American Joint Committee on Cancer (AJCC) criteria are routinely used for this purpose but can yield equivocal conclusions. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0c5a4eb7514bea66b56be6c3f0e16a7
https://doi.org/10.1016/j.jmoldx.2017.07.006

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Next-Generation Sequencing: A Novel Approach to Distinguish Multifocal Primary Lung Adenocarcinomas from Intrapulmonary Metastases

Autor: Snehal B, Patel, Wendy, Kadi, Ann E, Walts, Alberto M, Marchevsky, Andy, Pao, Angela, Aguiluz, Tudor, Mudalige, Zhenqui, Liu, Nan, Deng, Jean, Lopategui

Publikováno v: The Journal of molecular diagnostics : JMD. 19(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::53256bc69e6dd995e78eef2345898b43
https://pubmed.ncbi.nlm.nih.gov/28866070

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BRAF genetic heterogeneity in papillary thyroid carcinoma and its metastasis

Autor: Andy Pao, Shikha Bose, Ann E. Walts, Wendy Sacks

Publikováno v: Human Pathology. 45:935-941

Summary Intratumoral heterogeneity is widely recognized as an important determinant of a cancer's initial response and its subsequent resistance to targeted therapy. BRAF V600E mutation, common in papillary thyroid carcinoma (PTC), is helpful in fine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cad3bc87a647ee6bab0e0bc891001e0
https://doi.org/10.1016/j.humpath.2013.12.005

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Significant Reduction of ATP Production in PHA-Activated CD4+ Cells in 1-Day-Old Blood from Transplant Patients

Autor: Artur Karasyov, Washington Lim, Stanley C. Jordan, Odette A. Galera, Andy Pao, George Chaux, Elina Suviolahti, James Mirocha, Lawrence S.C. Czer, Jeffrey De Leon, Anna Petrosyan, Shili Ge, Anne Maria Jimenez, Mieko Toyoda, David Thomas

Publikováno v: Transplantation. 94:1243-1249

Background. Global immunosuppression can be measured by assessing adenosine triphospate (ATP) levels in mitogen-stimulated CD4+ T cells.Methods. We investigated the effect of storage time on ATP levels in 234 blood samples from 18 healthy individuals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0298c0e2caffe9c3a26897a8880c8047
https://doi.org/10.1097/tp.0b013e318270f322

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IFNγ production by NK cells from HLA-sensitized patients after in vitro exposure to allo-antigens

Autor: Artur Karasyov, Angela Aguiluz, Stanley C. Jordan, Andy Pao, Nathan Deer, Mieko Toyoda, Ashley Vo, P. Pichurin, Shili Ge, Elina Suviolahti, Bong-Ha Shin

Publikováno v: Transplant Immunology. 26:107-112

Using a novel cytokine flow cytometry test (allo-CFC), we have previously shown that incubation of allogeneic cells with peripheral blood from highly-HLA sensitized (HS) patients results in reproducible gamma-interferon (IFNγ production in CD3(-) ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea4955b25e6a17799d915bd0493bad6
https://doi.org/10.1016/j.trim.2011.11.001

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Mycophenolic acid and intravenous immunoglobulin exert an additive effect on cell proliferation and apoptosis in the mixed lymphocyte reaction

Autor: Andy Pao, Stanley C. Jordan, Nurmamet Amet, Lara Baden, Raju Radha, Kavita G. Sharma, Mieko Toyoda

Publikováno v: Transplant Immunology. 23:117-120

Intravenous immunoglobulin (IVIG) has known immunomodulatory effects in autoimmune diseases and transplantation and is commonly used in desensitization protocols and for treatment of antibody-mediated rejection (AMR). IVIG inhibits the MLR and induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1deb8143cc55685a41bedae27888b6c
https://doi.org/10.1016/j.trim.2010.04.009

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Concurrent inhibition of MYC and BCL2 is a potentially effective treatment strategy for double hit and triple hit B-cell lymphomas

Autor: Fred P. Rosenfelt, Melissa Cervania, Sepehr Rokhsar, Andy Pao, Bekir Cinar, Jean Lopategui, Raju Pillai, Serhan Alkan, Munevver Cinar

Publikováno v: Leukemia research. 39(7)

Double hit lymphoma or triple hit lymphoma (DHL/THL) is a rare form of aggressive B-Cell Lymphoma. Overexpression of MYC, BCL2 or/and BCL6 due to genomic rearrangements are the key molecular features of DHL/THL. Patients with DHL/THL show very aggres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33ce229813f753fc9e5c7098fe3502a
https://pubmed.ncbi.nlm.nih.gov/25916698

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Immunomodulatory Effects of Combination of Pooled Human Gammaglobulin and Rapamycin on Cell Proliferation and Apoptosis in the Mixed Lymphocyte Reaction

Autor: Andy Pao, Anna Petrosyan, Mieko Toyoda, Stanley C. Jordan

Publikováno v: Transplantation. 78:1134-1138

Background. Multidrug immunosuppressive regimens benefit transplant recipients, reducing side effects and creating synergy between medications with different mechanisms of action. We have shown that pooled human gammaglobulin (intravenous immunoglobu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad7a0fd713268732e947dd97063edbd
https://doi.org/10.1097/01.tp.0000134974.16614.ea

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