Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Andy Menzies"'
Autor:
Sam Behjati, Gunes Gundem, David C. Wedge, Nicola D. Roberts, Patrick S. Tarpey, Susanna L. Cooke, Peter Van Loo, Ludmil B. Alexandrov, Manasa Ramakrishna, Helen Davies, Serena Nik-Zainal, Claire Hardy, Calli Latimer, Keiran M. Raine, Lucy Stebbings, Andy Menzies, David Jones, Rebecca Shepherd, Adam P. Butler, Jon W. Teague, Mette Jorgensen, Bhavisha Khatri, Nischalan Pillay, Adam Shlien, P. Andrew Futreal, Christophe Badie, ICGC Prostate Group, Ultan McDermott, G. Steven Bova, Andrea L. Richardson, Adrienne M. Flanagan, Michael R. Stratton, Peter J. Campbell
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with
Externí odkaz:
https://doaj.org/article/6591661632a94c5d9e36a5a48f8dcf2c
Autor:
Hayley J. Luxton, David Nicol, Chris Ogden, Tokhir Dadaev, Katalin Karaszi, Douglas F. Easton, David E. Neal, Michael R. Stratton, David C. Wedge, Adam Butler, William J. Howat, Jon W. Teague, Sam Behjati, Elizabeth Bancroft, Susanna L. Cooke, Yongwei Yu, Barbara Kremeyer, Peter Van Loo, Pardeep Kumar, Freddie C. Hamdy, Helen Davies, Gunes Gundem, Simon Tavaré, Sarah Thomas, Christopher S. Foster, Anthony C. H. Ng, Erik Mayer, Naomi Livni, Niedzica Camacho, Sarah O’Meara, Cyril Fisher, Gill Pelvender, Nening Dennis, Ultan McDermott, David T. Jones, Jorge Zamora, Adam Lambert, Andy G. Lynch, Mette Jorgensen, Manasa Ramakrishna, Bhavisha Khatri, Andy Menzies, Steven Hazell, Nimish Shah, Susan Merson, Jilur Ghori, Rosalind A. Eeles, Yong-Jie Lu, Anne Y. Warren, Claire Hardy, Adrienne M. Flanagan, Rebecca Shepherd, Tim Dudderidge, Jonathan Kay, Calli Latimer, Ludmil B. Alexandrov, G. Steven Bova, Patrick S. Tarpey, Serena Nik-Zainal, Claire Verrill, Hongwei Zhang, Steve Hawkins, P. Andrew Futreal, Christopher Greenman, Peter J. Campbell, Daniel Leongamornlert, Nischalan Pillay, Keiran Raine, Charlie E. Massi, Sandra L. Edwards, Alan J. Thompson, Lucy Matthews, Cathy Corbishley, Andrea L. Richardson, Adam Shlien, Lucy Stebbings, Christophe Badie, Hayley C. Whitaker, Nicola D. Roberts, Vincent J. Gnanapragasam, Zsofia Kote-Jarai, Daniel M. Berney, Colin Cooper, Daniel Brewer
Publikováno v:
Europe PubMed Central
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Behjati, S, Gundem, G, Wedge, DC, Roberts, ND, Tarpey, PS, Cooke, SL, Van, L P, Alexandrov, LB, Ramakrishna, M, Davies, H, Nik-Zainal, S, Hardy, C, Latimer, C, Raine, KM, Stebbings, L, Menzies, A, Jones, D, Shepherd, R, Butler, AP & Teague, JW 2016, ' Mutational signatures of ionizing radiation in second malignancies. ', Nature Communications, vol. 7 . https://doi.org/10.1038/ncomms12605
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Behjati, S, Gundem, G, Wedge, DC, Roberts, ND, Tarpey, PS, Cooke, SL, Van, L P, Alexandrov, LB, Ramakrishna, M, Davies, H, Nik-Zainal, S, Hardy, C, Latimer, C, Raine, KM, Stebbings, L, Menzies, A, Jones, D, Shepherd, R, Butler, AP & Teague, JW 2016, ' Mutational signatures of ionizing radiation in second malignancies. ', Nature Communications, vol. 7 . https://doi.org/10.1038/ncomms12605
Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched for signatures of ionizin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32a7d5e46ccdd97f9b6dec571c3de76
https://www.nature.com/articles/ncomms12605#supplementary-information
https://www.nature.com/articles/ncomms12605#supplementary-information
Autor:
Andy Menzies, Adam Butler, Jon W. Teague, Peter J. Campbell, Serena Nik-Zainal, Helen Davies, Patrick S. Tarpey
Publikováno v:
Current Protocols in Bioinformatics
Copyright © 2015 John Wiley & Sons, Inc. VAGrENT is a tool that provides biological context and effect prediction for genomic sequence variants. It annotates single base substitutions and small insertions and deletions by comparing them to reference
Autor:
Benedikt Brors, Hidewaki Nakagawa, Peter J. Campbell, Susanne Gröbner, Natalie Jäger, Jones Dtw, Fujimoto A, Sasithorn Chotewutmontri, Patrick S. Tarpey, Keiran Raine, Matthias Schlesner, Liu Xi, Sophia Derdak, Stefan M. Pfister, Paolo Ribeca, David A. Wheeler, Takafumi N. Yamaguchi, John Douglas Mcpherson, Adam Butler, Jonathon Hinton, Sertier A, Christopher Previti, Peter Lichter, Michael Heinold, Andrey Korshunov, Jon W. Teague, Lawrence E. Heisler, Rolf Kabbe, Robert E. Denroche, Lucy Stebbings, Timothy Beck, Barbara Hutter, Ivo Buchhalter, Andy Menzies, Gut M, Roland Eils, Gut I, Paul C. Boutros, Nicolle Diessl, Lars Feuerbach, Rebecca Shepherd, Sabine Schmidt, Tyler Alioto, Laurie Tonon, Nicholas J. Harding, David T. Jones
As next-generation sequencing becomes a clinical tool, a full understanding of the variables affecting sequencing analysis output is required. Through the International Cancer Genome Consortium (ICGC), we compared sequencing pipelines at five indepen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4baca1d200f5752d024366421bafc447
https://doi.org/10.1101/013177
https://doi.org/10.1101/013177
Autor:
Ed Dicks, Michael R. Stratton, Simon A. Forbes, David S. Richardson, Sarah Edkins, Helen Davies, Richard Wooster, C. Mattocks, Phil Stephens, Patrick S. Tarpey, Keiran Raine, Andy Jenkinson, Christopher Greenman, P A Futreal, Rebecca Shepherd, Andy Menzies, Adam Butler, Jon W. Teague, Kristian Gray, Andrew D. Yates
Publikováno v:
Bioinformatics (Oxford, England)
The undertaking of large-scale DNA sequencing screens for somatic variants in human cancers requires accurate and rapid processing of traces for variants. Due to their often aneuploid nature and admixed normal tissue, heterozygous variants found in p
Autor:
Sally Bamford, Simon A. Forbes, Michael R. Stratton, D Breare, P A Futreal, Chai Yin Kok, Jon W. Teague, Mingming Jia, Andy Menzies, Charlotte G. Cole, Kenric Leung, Nidhi Bindal, Rebecca Shepherd
Publikováno v:
Nature Precedings.
"COSMIC, the Catalogue Of Somatic Mutations In Cancer":http://www.sanger.ac.uk/cosmic is designed to store and display somatic mutation information relating to human cancers, combining detailed information on publications, samples and mutation types.
Autor:
Mingming Jia, Jennifer Cole, Chai Kok, Michael R. Stratton, Jon W. Teague, Andy Menzies, Simon A. Forbes, Gurpreet Tang, Elisabeth Dawson, P. Andrew Futreal, Sally Bamford
Publikováno v:
NCI Nature Pathway Interaction Database.
Autor:
David N. Louis, Syd Barthorpe, Peter J. Campbell, Richard Wooster, Claire Stevens, Douglas F. Easton, Daniel P. Cahill, Ewan Birney, Keiran Raine, Simon A. Forbes, Gurpreet Bhamra, Jon Hinton, Michael R. Stratton, Tim Avis, Barbara L. Weber, Andy Menzies, Bhudipa Choudhury, Yoke Eng Chiew, Andrew D. Yates, Georgia Chenevix-Trench, Imre Vastrik, Gillian L. Dalgliesh, Andrew G. Nicholson, Alexandra Small, Ed Dicks, Janet Perry, Anthony R. Green, Sarah O’Meara, Raffaella Smith, Rachel Harrison, Bin Tean Teh, Sofie West, Tony Webb, Adam Butler, Sara Widaa, Gemma Buck, Rebecca Shepherd, Jennifer Cole, Sarah Edkins, Jennifer Varian, Peter Goldstraw, Andy Jenkinson, Jon W. Teague, Helen Davies, Sok Kean Khoo, Kris Gray, Suet Yi Leung, Calli Tofts, Dave Richardson, Christopher Greenman, P. Andrew Futreal, Tatiana Mironenko, Jody Clements, David T. Jones, Anna deFazio, Katy Hills, Kelly Halliday, Min-Han Tan, Siu Tsan Yuen, Philip J. Stephens, Christopher I. Hunter, Francis Brasseur, Leendert H. J. Looijenga, Mel Greaves, Esther Schmidt, Graham R. Bignell
Cancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence led us to propose that systematic resequencing of cancer genomes for mutations would lead to the discovery of many addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8181b6b39035a77f21373fb15d405e3d
https://europepmc.org/articles/PMC2712719/
https://europepmc.org/articles/PMC2712719/
Autor:
Jiqiu Cheng, Laura Mudie, Stuart McLaren, Adam Shlien, Amy Capper, David T. Jones, Sarah O’Meara, Derek L. Stemple, Jennifer Yen, David J. Adams, Alison M. Taylor, Steve Gamble, Ian R. Watson, Jennifer Richardson, Leonard I. Zon, Manasa Ramakrishna, E. Elizabeth Patton, David C. Wedge, Peter J. Campbell, Mike Dovey, James A. Lister, Lynda Chin, Chang-Jiun Wu, Richard M. White, John Marshall, Keiran Raine, Charles K. Kaufman, Patrick S. Tarpey, Serena Nik-Zainal, Yves Moreau, P. Andy Futreal, Inigo Martincorena, Ian Whitmore, Calli Latimer, Erin M Langdon, Adam Butler, Jon W. Teague, Peter Van Loo, Andy Menzies, Jeroen de Ridder
Publikováno v:
Genome Biology
Genome Biology, 14, 2013
Yen, J, White, R M, Wedge, D C, Van Loo, P, de Ridder, J, Capper, A, Richardson, J, Jones, D, Raine, K, Watson, I R, Wu, C-J, Cheng, J, Martincorena, I, Nik-Zainal, S, Mudie, L, Moreau, Y, Marshall, J, Ramakrishna, M, Tarpey, P, Shlien, A, Whitmore, I, Gamble, S, Latimer, C, Langdon, E, Kaufman, C, Dovey, M, Taylor, A, Menzies, A, McLaren, S, O Meara, S, Butler, A, Teague, J, Lister, J, Chin, L, Campbell, P, Adams, D J, Zon, L I, Patton, E E, Stemple, D L & Futreal, P A 2013, ' The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models ', Genome Biology, vol. 14, no. 10, R113 . https://doi.org/10.1186/gb-2013-14-10-r113
Genome Biology, 14, 2013
Yen, J, White, R M, Wedge, D C, Van Loo, P, de Ridder, J, Capper, A, Richardson, J, Jones, D, Raine, K, Watson, I R, Wu, C-J, Cheng, J, Martincorena, I, Nik-Zainal, S, Mudie, L, Moreau, Y, Marshall, J, Ramakrishna, M, Tarpey, P, Shlien, A, Whitmore, I, Gamble, S, Latimer, C, Langdon, E, Kaufman, C, Dovey, M, Taylor, A, Menzies, A, McLaren, S, O Meara, S, Butler, A, Teague, J, Lister, J, Chin, L, Campbell, P, Adams, D J, Zon, L I, Patton, E E, Stemple, D L & Futreal, P A 2013, ' The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models ', Genome Biology, vol. 14, no. 10, R113 . https://doi.org/10.1186/gb-2013-14-10-r113
Background: Melanoma is the most deadly form of skin cancer. Expression of oncogenic BRAF or NRAS, which are frequently mutated in human melanomas, promote the formation of nevi but are not sufficient for tumorigenesis. Even with germline mutated p53