Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Andy K. M. Lam"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
TMEM16A, a calcium-activated chloride channel involved in multiple cellular processes, is implicated in various diseases, but its pharmacology remains poorly understood. Here, the authors combine cryo-EM and electrophysiology to elucidate the mechani
Externí odkaz:
https://doaj.org/article/5d1b9a163c054c4cae603e1df40fff54
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The binding of cytoplasmic Ca2+ to the anion-selective channel TMEM16A triggers a conformational change around its binding site that is coupled to the release of a gate at the constricted neck. Here authors use cryo-EM and electrophysiology to identi
Externí odkaz:
https://doaj.org/article/9692a1f9cb0b436287d7a34b62620d89
Autor:
Andy K. M. Lam, Raimund Dutzler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The anion channel TMEM16A is activated by intracellular Ca2+ in a highly cooperative process. Here authors combine electrophysiology and autocorrelation analysis to observe the sampling of intermediate conformations during gating.
Externí odkaz:
https://doaj.org/article/0fcb6ff7244a49a3bb6ea4d49b731975