Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Andy K. M. Lam"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
TMEM16A, a calcium-activated chloride channel involved in multiple cellular processes, is implicated in various diseases, but its pharmacology remains poorly understood. Here, the authors combine cryo-EM and electrophysiology to elucidate the mechani
Externí odkaz:
https://doaj.org/article/5d1b9a163c054c4cae603e1df40fff54
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The binding of cytoplasmic Ca2+ to the anion-selective channel TMEM16A triggers a conformational change around its binding site that is coupled to the release of a gate at the constricted neck. Here authors use cryo-EM and electrophysiology to identi
Externí odkaz:
https://doaj.org/article/9692a1f9cb0b436287d7a34b62620d89
Autor:
Andy K. M. Lam, Raimund Dutzler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The anion channel TMEM16A is activated by intracellular Ca2+ in a highly cooperative process. Here authors combine electrophysiology and autocorrelation analysis to observe the sampling of intermediate conformations during gating.
Externí odkaz:
https://doaj.org/article/0fcb6ff7244a49a3bb6ea4d49b731975
Publikováno v:
Nature Communications; 5/19/2022, Vol. 13 Issue 1, p1-13, 13p
Autor:
Lam, Andy K. M., Dutzler, Raimund
Publikováno v:
Nature Communications; 2/4/2021, Vol. 12 Issue 1, p1-14, 14p
Publikováno v:
Nature Communications; 2/4/2021, Vol. 12 Issue 1, p1-13, 13p
Publikováno v:
Nature; 6/16/2018, Vol. 558 Issue 7709, p254-259, 6p, 4 Diagrams, 1 Chart, 11 Graphs
Publikováno v:
Science Signaling; 5/20/2014, Vol. 7 Issue 326, p1-11, 11p