Výsledky vyhledávání - "Andy K. L. Nguy"

Modulating OxyB-Catalyzed Cross-Coupling Reactions in Vancomycin Biosynthesis by Incorporation of Diverse d-Tyr Analogues

Autor: Clarissa C. Forneris, Mohammad R. Seyedsayamdost, Seyma Ozturk, Andy K. L. Nguy, Erik J. Sorensen

Publikováno v: The Journal of Organic Chemistry. 83:7309-7317

We report a general method for synthesizing diverse d-Tyr analogues, one of the constituents of the antibiotic vancomycin, using a Negishi cross-coupling protocol. Several analogues were incorporated into the vancomycin substrate-peptide and reacted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a539ea622febb00441cdbc5aeb0853ed
https://doi.org/10.1021/acs.joc.8b00916

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Detecting and Characterizing the Kinetic Activation of Thermal Networks in Proteins: Thermal Transfer from a Distal, Solvent-Exposed Loop to the Active Site in Soybean Lipoxygenase

Autor: Natalie Minnetian, Andy K. L. Nguy, Adam R. Offenbacher, Anthony T. Iavarone, Judith P. Klinman, Zhenyu Deng, Jan Paulo T. Zaragoza

Publikováno v: J Phys Chem B
The journal of physical chemistry. B, vol 123, iss 41

The rate-limiting chemical reaction catalyzed by soybean lipoxygenase (SLO) involves quantum mechanical tunneling of a hydrogen atom from substrate to its active site ferric-hydroxide cofactor. SLO has emerged as a prototypical system for linking the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f795b1ac588ee32abf65b61f67b3e36
https://pubmed.ncbi.nlm.nih.gov/31580070

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Solvent and Temperature Probes of the Long-Range Electron-Transfer Step in Tyramine β-Monooxygenase: Demonstration of a Long-Range Proton-Coupled Electron-Transfer Mechanism

Autor: Monika Sommerhalter, Andy K. L. Nguy, Judith P. Klinman, Hui Zhu

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, vol 137, iss 17

Tyramine β-monooxygenase (TβM) belongs to a family of physiologically important dinuclear copper monooxygenases that function with a solvent-exposed active site. To accomplish each enzymatic turnover, an electron transfer (ET) must occur between tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600737f26604257b25f2538663267bfd
https://pubmed.ncbi.nlm.nih.gov/25919134

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