Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Andy J. Harker"'
Autor:
Victoria J. Barrett, Feng Wang, Christopher Browning, Matthew J Lindon, Henry M. Sarau, James A. Fornwald, Andy J. Harker, Guido Hartmann, Jeffery K. Kerns, David P. Andrew, Graeme Irvine Stevenson, Ashley Paul Hancock, Victoria Vinader, Michael L. Moore, James J. Foley, Jian Jin, Parvathi Rao, Anthony J. Jurewicz, Helen E. Connor, Dwight M. Morrow, Kristen E. Belmonte, Yonghui Wang, Ralph A. Rivero, Cuc Nguyen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1722-1725
High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f387c8ba0cdb9889dd18456ec30b9e
https://doi.org/10.1016/j.bmcl.2006.12.076
https://doi.org/10.1016/j.bmcl.2006.12.076
Autor:
Kathrine J. Smith, Roberto Profeta, Simon E. Ward, Marta Neve, Simone Spada, Beatrice Oliosi, Jesper Lund, Andrew Jonathan Harris, Anna Mingardi, Claudette Mookherjee, Stuart P. Ballantine, Rosemary A. Melarange, Laura Aldegheri, Andy J. Harker, Benjamin D. Bax, Mark H Harries, Kevin M. Thewlis, Paul W. Smith, Daniele Andreotti, J. Mosley, Shahnaz P. Yusaf
Publikováno v:
Journal of medicinal chemistry. 53(15)
A series of AMPA receptor positive allosteric modulators has been optimized from poorly penetrant leads to identify molecules with excellent preclinical pharmacokinetics and CNS penetration. These discoveries led to 17i, a potent, efficacious CNS pen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154b627b7254de36c15c9e847ad6636c
https://pubmed.ncbi.nlm.nih.gov/20614889
https://pubmed.ncbi.nlm.nih.gov/20614889
Autor:
Andy J. Harker, Simon Taylor
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 41(1)
Plasma protein binding (PPB) methodology suitable for application in the lead optimisation of a corticosteroid series known to demonstrate non-specific binding (NSB) and poor solubility has been established. The method involved a modification to stan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371d8f23535c9bf475f0ec4673efb23a
https://pubmed.ncbi.nlm.nih.gov/16314065
https://pubmed.ncbi.nlm.nih.gov/16314065
Autor:
Andy J. Harker, Elizabeth K. Hussey, Susan T. Hall, Mick J. Daniel, Gary L. Evans, Karl H. Donn
Publikováno v:
The Journal of Clinical Pharmacology. 34:975-977
3TC is a dideoxy-nucleoside analogue that has demonstrated in-vitro activity against human immunodeficiency virus (HIV). 3TC concentrations in humans were predicted before the initiation of clinical trials by interspecies scaling of pharmacokinetic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66787afc8fc417cba9d64cfecdd40001
https://doi.org/10.1002/j.1552-4604.1994.tb01968.x
https://doi.org/10.1002/j.1552-4604.1994.tb01968.x
Autor:
Rupert E. Shaw, Andy J. Harker, Panayiotis Alexandro Procopiou, Michael A. Snowden, Colin M. Burgess, Helen E. Weston, Ashley Paul Hancock, Sarah Walton, Rob J. Stubbs, Rosanne M. Farrell, Richard M. Angell, Chris Ioannou, Onkar M. P. Singh, Wendy R. Irving, Yemisi E. Solanke, Keith Biggadike
Publikováno v:
Journal of medicinal chemistry. 43(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efd138007f0925d3f8cfe9a195fd5b6
https://pubmed.ncbi.nlm.nih.gov/10633034
https://pubmed.ncbi.nlm.nih.gov/10633034