Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Andy Hee-Meng Tan"'
Autor:
Meiyappan Lakshmanan, Sean Chia, Kuin Tian Pang, Lyn Chiin Sim, Gavin Teo, Shi Ya Mak, Shuwen Chen, Hsueh Lee Lim, Alison P. Lee, Farouq Bin Mahfut, Say Kong Ng, Yuansheng Yang, Annie Soh, Andy Hee-Meng Tan, Andre Choo, Ying Swan Ho, Terry Nguyen-Khuong, Ian Walsh
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2497-2506 (2024)
N-glycosylation can have a profound effect on the quality of mAb therapeutics. In biomanufacturing, one of the ways to influence N-glycosylation patterns is by altering the media used to grow mAb cell expression systems. Here, we explore the potentia
Externí odkaz:
https://doaj.org/article/8c61532e278a4848aa34e06e0575d137
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Adoptive cellular immunotherapy as a new paradigm to treat cancers is exemplified by the FDA approval of six chimeric antigen receptor-T cell therapies targeting hematological malignancies in recent years. Conventional αβ T cells applied in these t
Externí odkaz:
https://doaj.org/article/69472357978f47b8999c2bb0edaf4ee0
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Niche cells are widely known to regulate stem/progenitor cells in many mammalian tissues. In the hair, dermal papilla niche cells are well accepted to regulate hair stem/progenitor cells. However, how niche cells themselves are maintained is
Externí odkaz:
https://doaj.org/article/f61eece7eaf44375b893ba27101645a2
Autor:
Zhenzhong Chen, Seokgyu Han, Arleen Sanny, Dorothy Leung-Kwan Chan, Danny van Noort, Wanyoung Lim, Andy Hee-Meng Tan, Sungsu Park
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background Most high-throughput screening (HTS) systems studying the cytotoxic effect of chimeric antigen receptor (CAR) T cells on tumor cells rely on two-dimensional cell culture that does not recapitulate the tumor microenvironment (TME).
Externí odkaz:
https://doaj.org/article/94cb8601dee847fbae7cc6f4b7bc3916
Autor:
Jia Tong Loh, Koon-Guan Lee, Alison P. Lee, Joey Kay Hui Teo, Hsueh Lee Lim, Susana Soo-Yeon Kim, Andy Hee-Meng Tan, Kong-Peng Lam
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Abstract How pathogenesis of inflammatory bowel disease (IBD) depends on the complex interplay of host genetics, microbiome and the immune system is not fully understood. Here, we showed that Downstream of Kinase 3 (DOK3), an adapter protein involved
Externí odkaz:
https://doaj.org/article/9e614d935ff7407392251563afe5b819
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/e2387f44ed24463188790ad6ff13d3a5
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/2042fa72db0f44698267ec3b03109a15
Autor:
Xiaohui Wang, Xiang Lin, Zihan Zheng, Bingtai Lu, Jun Wang, Andy Hee-Meng Tan, Meng Zhao, Jia Tong Loh, Sze Wai Ng, Qian Chen, Fan Xiao, Enyu Huang, King-Hung Ko, Zhong Huang, Jingyi Li, Kin-Hang Kok, Gen Lu, Xiaohui Liu, Kong-Peng Lam, Wanli Liu, Yuxia Zhang, Kwok-Yung Yuen, Tak Wah Mak, Liwei Lu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Influenza A infection results in γδ T cell influx and production of IL-17 in the lungs. Here, the authors show that this effect is primed by CD1-restricted ligands that are released by infected cells and presented by B1a cells in the lungs.
Externí odkaz:
https://doaj.org/article/232a7455244b4ab7a369fc9f8653e33a
Autor:
Chelsia Qiuxia Wang, Fong Chan Choy, Arleen Sanny, Takashi Murakami, Andy Hee-Meng Tan, Kong-Peng Lam
Publikováno v:
Cells, Vol 12, Iss 2, p 309 (2023)
Immune checkpoint blockade (ICB) therapy involves the inhibition of immune checkpoint regulators which reverses their limitation of T cell anti-tumor responses and results in long-lasting tumor regression. However, poor clinical response or tumor rel
Externí odkaz:
https://doaj.org/article/d5bb232d60fc4ffa93cfd7f37cd8e792
Autor:
Alan Tin-Lun Lam, Alison P. Lee, Premkumar Jayaraman, Kah Yong Tan, Deepak Raghothaman, Hsueh Lee Lim, He Cheng, Lihan Zhou, Andy Hee-Meng Tan, Shaul Reuveny, Steve Oh
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102272- (2021)
Mesenchymal stem cells (MSCs) are of great clinical interest as a form of allogenic therapy due to their excellent regenerative and immunomodulatory effects for various therapeutic indications. Stirred suspension bioreactors using microcarriers (MC)
Externí odkaz:
https://doaj.org/article/e551092b47f145818cc2f2864ed898d9