Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Andy Gribble"'
Autor:
Timothy N. C. Wells, Drake S. Eggleston, Tracey Wilkes, Pieter H. E. Groot, Lawrence Ivan Kruse, Andy Gribble, Roland E. Dolle, Barbara A. Saxty
Publikováno v:
Journal of Medicinal Chemistry. 38:537-543
ATP citrate lyase is an enzyme involved in mammalian lipogenesis and cholesterogenesis. Inhibitors of the enzyme represent a potentially novel class of hypolipidemic agents. Citric acid analogues 5-16 bearing electrophilic and latent electrophilic su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e95ad83123e7a1aa1341cc38c340cc
https://doi.org/10.1021/jm00003a016
https://doi.org/10.1021/jm00003a016
Autor:
George Okafo, Andy Gribble, Patrick Camilleri, Kathryn A. Hutton, Thomas Faller, David E. Games
Publikováno v:
ChemInform. 28
An acridone derivative containing an activated carboxylic group is highly reactive towards primary amine groups, and allows selective analysis either using absorbance at a wavelength of 410 nm or fluorescence at excitation and emission wavelengths of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::414a5b2ec8d613042ae36f1dc5d6db38
https://doi.org/10.1002/chin.199747229
https://doi.org/10.1002/chin.199747229
Autor:
Martyn D. Wood, Daniele Donati, Steve P. Watson, Claire M. Howes, Payne Andrew H, Patrick M. Woollard, Silvia Terreni, Romano Di Fabio, Ian Peter Holmes, Charlie Reavill, Andy Gribble, Angela Worby, Richard Blunt, Luca Arista, Stephen M. Blowers, Olivier Lorthioir, Dieter Hamprecht, Ian Stansfield, Fabrizio Micheli
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(6)
The identification of a highly selective D 2 partial agonist, D 3 antagonist tool molecule which demonstrates high levels of brain exposure and selectivity against an extensive range of dopamine, serotonin, adrenergic, histamine, and muscarinic recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d0ba34865e65682eabe24ee8d42e85
https://pubmed.ncbi.nlm.nih.gov/20153647
https://pubmed.ncbi.nlm.nih.gov/20153647
Autor:
Maria Pilla, Giovanna Tedesco, Ornella Perini, Jim J. Hagan, Daniele Donati, Christian Heidbreder, Michela Andreoli, Anna Checchia, Angela Worby, Dieter Hamprecht, Gabriella Gentile, Marcella Petrone, Cristiana Griffante, Ornella Curcuruto, Silvia Terreni, Adam J. Schwarz, Charles R. Ashby, Enzo Valerio, Manolo Mugnaini, Laurent Lacroix, Alexander Baxter Smith, Claire Scott, Andy Gribble, Alessandro Gozzi, Federica Damiani, Michela Pecoraro, Geoff Stemp, Frank E. Blaney, Di Fabio Romano, Angelo Bifone, Andrew Glaxosmithkline Lightfoot, Martyn Wood, Luca Tarsi, Fabrizio Micheli, Gregor James Macdonald, Giorgio Bonanomi, Jacqui Piner, Tino Rossi, Simone Braggio, Anna Maria Capelli
Publikováno v:
Journal of medicinal chemistry. 50(21)
The discovery of new highly potent and selective dopamine D3 receptor antagonists has recently permitted characterization of the role of the dopamine D3 receptor in a wide range of preclinical animal models. A novel series of 1,2,4-triazol-3-yl-thiop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6539182e806c69f6da9b6ea9423ddeb
https://pubmed.ncbi.nlm.nih.gov/17867665
https://pubmed.ncbi.nlm.nih.gov/17867665
Autor:
David G. Tew, Virendra P. Shah, Pieter H.E. Groot, H Boyd, Robert J. Ife, John W. Yates, Antony Nicholas Shaw, R C Haltiwanger, S Bakewell, David McNair, G Okafo, S Ashman, Neil Pearce, C. E. Novelli, Andy Gribble, R. E. Dolle, Drake S. Eggleston
Publikováno v:
Journal of medicinal chemistry. 41(19)
A series of (3R,5S)-omega-substituted-3-carboxy-3, 5-dihydroxyalkanoic acids have been synthesized and evaluated as inhibitors of the recombinant human form of ATP-citrate lyase. The best of these have Ki's in the 200-1000 nM range. As the correspond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62217e309d18eb3cd032e1ccd00dab3f
https://pubmed.ncbi.nlm.nih.gov/9733484
https://pubmed.ncbi.nlm.nih.gov/9733484
Autor:
George Okafo, David E. Games, Kathryn A. Hutton, Thomas Faller, Patrick Camilleri, Andy Gribble
Publikováno v:
Chemical Communications. :1529-1530
An acridone derivative containing an activated carboxylic group is highly reactive towards primary amine groups, and allows selective analysis either using absorbance at a wavelength of 410 nm or fluorescence at excitation and emission wavelengths of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2080aaad51e95caad2b3607a309c65b2
https://doi.org/10.1039/a701787a
https://doi.org/10.1039/a701787a
Autor:
Fabrizio Micheli, Giorgio Bonanomi, Frank E. Blaney, Simone Braggio, Anna Maria Capelli, Anna Checchia, Ornella Curcuruto, Federica Damiani, Romano Di Fabio, Daniele Donati, Gabriella Gentile, Andy Gribble, Dieter Hamprecht, Giovanna Tedesco, Silvia Terreni, Luca Tarsi, Andrew Lightfoot, Geoff Stemp, Gregor MacDonald, Alex Smith
Publikováno v:
Journal of Medicinal Chemistry; Oct2007, Vol. 50 Issue 21, p5076-5089, 14p