Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Andy Greenfield"'
Autor:
Isabelle Stévant, Françoise Kühne, Andy Greenfield, Marie-Christine Chaboissier, Emmanouil T. Dermitzakis, Serge Nef
Publikováno v:
Cell Reports, Vol 26, Iss 12, Pp 3272-3283.e3 (2019)
Summary: Sex determination is a unique process that allows the study of multipotent progenitors and their acquisition of sex-specific fates during differentiation of the gonad into a testis or an ovary. Using time series single-cell RNA sequencing (s
Externí odkaz:
https://doaj.org/article/cce02257bf094e28a23769e1b91fdbb5
Autor:
Pam Siggers, Gwenn-Aël Carré, Debora Bogani, Nick Warr, Sara Wells, Helen Hilton, Chris Esapa, Mohammad K Hajihosseini, Andy Greenfield
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100447 (2014)
The secreted molecule fibroblast growth factor 9 (FGF9) plays a critical role in testis determination in the mouse. In embryonic gonadal somatic cells it is required for maintenance of SOX9 expression, a key determinant of Sertoli cell fate. Conditio
Externí odkaz:
https://doaj.org/article/b46f7a2ea5db4085af07bdc27de8d884
Autor:
Nick Warr, Debora Bogani, Pam Siggers, Rachel Brixey, Hilda Tateossian, Asha Dopplapudi, Sara Wells, Michael Cheeseman, Ying Xia, Harry Ostrer, Andy Greenfield
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19572 (2011)
In mammals, the Y chromosome is a dominant male determinant, causing the bipotential gonad to develop as a testis. Recently, cases of familial and spontaneous 46,XY disorders of sex development (DSD) have been attributed to mutations in the human gen
Externí odkaz:
https://doaj.org/article/90c4c456a12b4bcdaab8107f57443116
Autor:
Debora Bogani, Pam Siggers, Rachel Brixey, Nick Warr, Sarah Beddow, Jessica Edwards, Debbie Williams, Dagmar Wilhelm, Peter Koopman, Richard A Flavell, Hongbo Chi, Harry Ostrer, Sara Wells, Michael Cheeseman, Andy Greenfield
Publikováno v:
PLoS Biology, Vol 7, Iss 9, p e1000196 (2009)
Sex determination in mammals is controlled by the presence or absence of the Y-linked gene SRY. In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9, a transcription
Externí odkaz:
https://doaj.org/article/c8776f4de498418bbb421a64b4c2a399
Autor:
Lee Smith, John Willan, Nick Warr, Frances A Brook, Michael Cheeseman, Richard Sharpe, Pam Siggers, Andy Greenfield
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e4091 (2008)
The mammalian gonad arises as a bipotential primordium from which a testis or ovary develops depending on the chromosomal sex of the individual. We have previously used DNA microarrays to screen for novel genes controlling the developmental fate of t
Externí odkaz:
https://doaj.org/article/874626d44c6a47d0ab62ac88e316edf9
Autor:
Andy Greenfield
Publikováno v:
Current Opinion in Endocrine and Metabolic Research. 18:1-7
The granulosa cell is the somatic supporting cell of the ovary and plays critical roles in follicle development and germ cell development. In the adult female, granulosa cells continue to support the oocyte, allowing it to be ovulated and, ultimately
Autor:
Andy Greenfield, Pawel Herzyk, Angela K Lucas-Herald, Ruth McGowan, Scottish Genomes Partnership SGP, Rhian M Touyz, Nicola Williams, Edward S Tobias, Danielle Sagar, Augusto C Montezano, Francisco J Rios, Livia de Lucca Camargo, Graham Hamilton, Gabriella Gazdagh
Publikováno v:
Journal of the Endocrine Society. 6:A623-A624
Introduction XYdisorders of sex development (DSD) result from variants in many different human genes but frequently have no detectable molecular cause. In approximately 25% of cases of XY DSD, the index case may have associated malformations. Genetic
Autor:
Nick Warr, Pam Siggers, Joel May, Nicolas Chalon, Madeleine Pope, Sara Wells, Marie-Christine Chaboissier, Andy Greenfield
Publikováno v:
Reproduction
Reproduction, 2022, 163, pp.333-340. ⟨10.1530/REP-21-0443⟩
Reproduction, 2022, 163, pp.333-340. ⟨10.1530/REP-21-0443⟩
Sex determination in mammals is controlled by the dominance of either pro-testis (SRY-SOX9-FGF9) or pro-ovary (RSPO1-WNT4-FOXL2) genetic pathways during early gonad development in XY and XX embryos, respectively. We have previously shown that early,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d49f94595e554086181111647750e3
https://hal.science/hal-03650971
https://hal.science/hal-03650971
Autor:
Esra Arslan Ates, Mehmet Eltan, Bahadir Sahin, Busra Gurpinar Tosun, Tuba Seven Menevse, Bilgen Bilge Geckinli, Andy Greenfield, Serap Turan, Abdullah Bereket, Tulay Guran
Background The human INHA gene encodes the inhibin subunit alpha protein, which is common to both inhibin A and B. The functional importance of inhibins in male sex development, sexual function, and reproduction remain largely unknown. Objective We r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a73cd30156b0a2ab39c81fd219367f
https://hdl.handle.net/11424/287187
https://hdl.handle.net/11424/287187
Autor:
Michelle Simon, Matthew Mackenzie, Sare Betul Kaygusuz, Zehra Yavas Abali, Busra Gurpinar Tosun, Hatice Kocak Eker, Nihal Hatipoglu, Sukran Poyrazoglu, Didem Helvacioglu, Mehmet Eltan, Firdevs Bas, Gozde Yesil, Gul Direk, Tuba Seven Menevse, Abdullah Bereket, Andy Greenfield, Lydia Teboul, Dilek Çiçek, Tulay Guran, Richard Reeves, Serap Turan, Nick Warr, Feyza Darendeliler
Publikováno v:
European Journal of Endocrinology
Context Homozygous and heterozygous variants in PPP2R3C are associated with syndromic 46,XY complete gonadal dysgenesis (Myo-Ectodermo-Gonadal Dysgenesis (MEGD) syndrome), and impaired spermatogenesis, respectively. This study expands the role of PPP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa57bd6bd3a6729eeb372c3600715ed
https://avesis.kayseri.edu.tr/publication/details/58cbde97-66b0-4e72-970c-81619c50e2ea/oai
https://avesis.kayseri.edu.tr/publication/details/58cbde97-66b0-4e72-970c-81619c50e2ea/oai