Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Andy Göbel"'
Autor:
Nikolai P. Jaschke, Sophie Pählig, Anupam Sinha, Timon E. Adolph, Maria Ledesma Colunga, Maura Hofmann, Andrew Wang, Sylvia Thiele, Julian Schwärzler, Alexander Kleymann, Marc Gentzel, Herbert Tilg, Ben Wielockx, Lorenz C. Hofbauer, Martina Rauner, Andy Göbel, Tilman D. Rachner
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
A combination of cell line, transgenic mouse and human genetic data implicates a proinflammatory function of Dickkopf1 across malignant and non-malignant cells.
Externí odkaz:
https://doaj.org/article/08ca554bb4284badb614763c54f2ed47
Autor:
Daniel Martin Klotz, Jan Dominik Kuhlmann, Theresa Link, Maren Goeckenjan, Lorenz C. Hofbauer, Andy Göbel, Tilman D. Rachner, Pauline Wimberger
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundNeuropilin (NRP) is a transmembrane protein, which has been shown to be a pro-angiogenic mediator and implicated as a potential driver of cancer progression. NRP-1 up-regulation in ovarian cancer tissue predicts poor prognosis. However, the
Externí odkaz:
https://doaj.org/article/03ee71a135cd4b958849b2d257f515b6
Autor:
Andy Göbel, Valentina M. Zinna, Stefania Dell’Endice, Nikolai Jaschke, Jan Dominik Kuhlmann, Pauline Wimberger, Tilman D. Rachner
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-17 (2020)
Abstract Background Ovarian cancer remains the most fatal gynecological malignancy. Current therapeutic options are limited due to late diagnosis in the majority of the cases, metastatic spread to the peritoneal cavity and the onset of chemo-resistan
Externí odkaz:
https://doaj.org/article/9646a631756b47db9076b98eec6dd654
Autor:
Lila Bemmerlein, Ilker A. Deniz, Jana Karbanová, Angela Jacobi, Stephan Drukewitz, Theresa Link, Andy Göbel, Lisa Sevenich, Anna V. Taubenberger, Pauline Wimberger, Jan Dominik Kuhlmann, Denis Corbeil
Publikováno v:
Cancers, Vol 14, Iss 3, p 603 (2022)
Breast cancer is a heterogeneous disease and the mechanistic framework for differential osteotropism among intrinsic breast cancer subtypes is unknown. Hypothesizing that cell morphology could be an integrated readout for the functional state of a ca
Externí odkaz:
https://doaj.org/article/d7b6267788fa4f82b0db279b5923ec11
Autor:
Andy Göbel, Stefania Dell’Endice, Nikolai Jaschke, Sophie Pählig, Amna Shahid, Lorenz C. Hofbauer, Tilman D. Rachner
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5078 (2021)
Tumor metastasis to bone is a common event in multiple forms of malignancy. Inflammation holds essential functions in homeostasis as a defense mechanism against infections and is a strategy to repair injured tissue and to adapt to stress conditions.
Externí odkaz:
https://doaj.org/article/b2dd1483e4844fddbbb8849e65767746
Autor:
Andrew J. Browne, Marie L. Kubasch, Andy Göbel, Peyman Hadji, David Chen, Martina Rauner, Friedrich Stölzel, Lorenz C. Hofbauer, Tilman D. Rachner
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-15 (2017)
Abstract Background The mammalian target of rapamycin inhibitor everolimus is approved as an antitumor agent in advanced estrogen receptor-positive breast cancer. Surrogate bone marker data from clinical trials suggest effects on bone metabolism, but
Externí odkaz:
https://doaj.org/article/444b18b9589b483c89b20d8fb31ffd36
Autor:
Andy Göbel, Jan D. Kuhlmann, Theresa Link, Pauline Wimberger, Cornelia Link-Rachner, Stefanie Thiele, Stefania Dell'Endice, Giulia Furesi, Dorit Breining, Martina Rauner, Lorenz C. Hofbauer, Tilman D. Rachner
Publikováno v:
Journal of Bone Oncology, Vol 16, Iss , Pp - (2019)
Background: Semaphorin 4D (Sema4D) is a glycoprotein that inhibits bone formation and has been associated with cancer progression and the occurrence of bone metastases. Recently, Sema4D expression has been linked to estrogen signaling in breast cance
Externí odkaz:
https://doaj.org/article/cd0e1a00e9d747cba09000e5c9236658
Autor:
Maria Wilke, Andy Göbel, Martina Rauner, Peggy Benad-Mehner, Norbert Schütze, Susanne Füssel, Peyman Hadji, Lorenz C. Hofbauer, Tilman D. Rachner
Publikováno v:
Journal of Bone Oncology, Vol 3, Iss 1, Pp 10-17 (2014)
Bone metastases represent common long term complications of patients with breast cancer. Zoledronic acid, an amino-bisphosphonate and mevalonate pathway inhibitor, is an established agent for the treatment of bone metastases. Direct antitumor effects
Externí odkaz:
https://doaj.org/article/b756a4b66b41474d8977d9443cecb1e8
Autor:
Peggy Benad-Mehner, Stefanie Thiele, Tilman D. Rachner, Andy Göbel, Martina Rauner, Lorenz C. Hofbauer
Publikováno v:
Journal of Bone Oncology, Vol 3, Iss 1, Pp 18-24 (2014)
Background: Breast cancer often metastasizes into bone and leads to osteolytic lesions. The underlying mechanisms, however, are complex and not fully understood. Syndecan-1 is a proteoglycan that has various functions relevant for tumor progression i
Externí odkaz:
https://doaj.org/article/51b6e63854de48e29bbc6652c27ea425
Autor:
Ann-Kathrin Bittner, Rainer Kimmig, Lorenz C. Hofbauer, Martina Rauner, Pauline Wimberger, Andrew Browne, Oliver Hoffmann, Kati Erdmann, Andy Göbel, Sabine Kasimir-Bauer, Tilman D. Rachner
Purpose:We assessed serum concentrations of the receptor activator of NFκB ligand (RANKL) and its decoy receptor, osteoprotegerin (OPG), two proteins implicated in the development and progression of breast cancer, in 509 patients with primary, nonme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472e23160ad5a32a18bbd11835bf45af
https://doi.org/10.1158/1078-0432.c.6526871.v1
https://doi.org/10.1158/1078-0432.c.6526871.v1