Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Andy D, Blanchard"'
Autor:
Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The PI3K/Akt/mTOR pathway has been previously implicated in fibrosis and a pan-PI3K/mTOR inhibitor is currently under clinical evaluation for the treatment of IPF. Here the authors show that the mTORC1/4E-BP1 axis is critical for TGF-β1-induced fibr
Externí odkaz:
https://doaj.org/article/c3c84960b35344d79ec192d4954f0d3a
Autor:
Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/35a6295d2586420286eccc316b713105
Autor:
Hannah V, Woodcock, Jessica D, Eley, Delphine, Guillotin, Manuela, Platé, Carmel B, Nanthakumar, Matteo, Martufi, Simon, Peace, Gerard, Joberty, Daniel, Poeckel, Robert B, Good, Adam R, Taylor, Nico, Zinn, Matthew, Redding, Ellen J, Forty, Robert E, Hynds, Charles, Swanton, Morten, Karsdal, Toby M, Maher, Andrew, Fisher, Giovanna, Bergamini, Richard P, Marshall, Andy D, Blanchard, Paul F, Mercer, Rachel C, Chambers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
Myofibroblasts are the key effector cells responsible for excessive extracellular matrix deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The PI3K/Akt/mTOR axis has been implicated in fibrosis, with pan-PI3K/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12557e14bc29bc74428c19dab93849b