Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Andy Cremers"'
Autor:
Mandy M.F. Steinbusch, Guus G.H. van den Akker, Andy Cremers, Adhiambo M.A. Witlox, Heleen M. Staal, Mandy J. Peffers, Lodewijk W. van Rhijn, Marjolein M.J. Caron, Tim J.M. Welting
Publikováno v:
Non-coding RNA Research, Vol 7, Iss 2, Pp 55-65 (2022)
Introduction: Ribosome biogenesis is integrated with many cellular processes including proliferation, differentiation and oncogenic events. Chondrogenic proliferation and differentiation require a high cellular translational capacity to facilitate ca
Externí odkaz:
https://doaj.org/article/bb29e52f629949dba5afb57af8b7828c
Autor:
Alzbeta Chabronova, Guus G.H. van den Akker, Mandy M.F. Meekels-Steinbusch, Franziska Friedrich, Andy Cremers, Don A.M. Surtel, Mandy J. Peffers, Lodewijk W. van Rhijn, Ekkehart Lausch, Bernhard Zabel, Marjolein M.J. Caron, Tim J.M. Welting
Publikováno v:
Non-coding RNA Research, Vol 6, Iss 4, Pp 211-224 (2021)
Mutations in the non-coding snoRNA component of mitochondrial RNA processing endoribonuclease (RMRP) are the cause of cartilage-hair hypoplasia (CHH). CHH is a rare form of metaphyseal chondrodysplasia characterized by disproportionate short stature
Externí odkaz:
https://doaj.org/article/d37c8f7d561c4191a6c92acb6d382bcf
Autor:
Ellen G. J. Ripmeester, Marjolein M. J. Caron, Guus G. H. van den Akker, Jessica Steijns, Don A. M. Surtel, Andy Cremers, Laura C. W. Peeters, Lodewijk W. van Rhijn, Tim J. M. Welting
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The fibrocartilage chondrocyte phenotype has been recognized to attribute to osteoarthritis (OA) development. These chondrocytes express genes related to unfavorable OA outcomes, emphasizing its importance in OA pathology. BMP7 is being expl
Externí odkaz:
https://doaj.org/article/01cfdb8fb7d54afe8a50c8e5b9da0ebe
Autor:
Marjolein M.J. Caron, Ellen G.J. Ripmeester, Guus van den Akker, Nina K.A. P. Wijnands, Jessica Steijns, Don A.M. Surtel, Andy Cremers, Pieter J. Emans, Lodewijk W. van Rhijn, Tim J.M. Welting
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 247-261 (2021)
Treatment of osteoarthritis (OA) is mainly symptomatic by alleviating pain to postpone total joint replacement. Bone morphogenetic protein 7 (BMP7) is a candidate morphogen for experimental OA treatment that favorably alters the chondrocyte and carti
Externí odkaz:
https://doaj.org/article/fe01f116b8f2411686d416b75c812172
Autor:
Panagiotis Balaskas, Katarzyna Goljanek-Whysall, Peter D. Clegg, Yongxiang Fang, Andy Cremers, Aibek Smagul, Tim J. M. Welting, Mandy J. Peffers
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1189 (2023)
Osteoarthritis is the most common degenerative joint disorder. MicroRNAs are gene expression regulators that act post-transcriptionally to control tissue homeostasis. Microarray analysis was undertaken in osteoarthritic intact, lesioned and young int
Externí odkaz:
https://doaj.org/article/1524c35eecee49269048b319151fb6a9
Autor:
Ellen G. J. Ripmeester, Tim J. M. Welting, Guus G. H. van den Akker, Don A. M. Surtel, Jessica S. J. Steijns, Andy Cremers, Lodewijk W. van Rhijn, Marjolein M. J. Caron
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
BMP7 is a morphogen capable of counteracting the OA chondrocyte hypertrophic phenotype via NKX3-2. NKX3-2 represses expression of RUNX2, an important transcription factor for chondrocyte hypertrophy. Since RUNX2 has previously been described as an in
Externí odkaz:
https://doaj.org/article/68066cf15959463cbf6882b07c7b2fb3
Autor:
Marjolein M. J. Caron, Maxime Eveque, Berta Cillero-Pastor, Ron M. A. Heeren, Bas Housmans, Kasper Derks, Andy Cremers, Mandy J. Peffers, Lodewijk W. van Rhijn, Guus van den Akker, Tim J. M. Welting
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
IntroductionIn addition to the well-known cartilage extracellular matrix-related expression of Sox9, we demonstrated that chondrogenic differentiation of progenitor cells is driven by a sharply defined bi-phasic expression of Sox9: an immediate early
Externí odkaz:
https://doaj.org/article/29467c415e404b3c97d0e75e58695b9e
Autor:
Marjolein M. J. Caron, Maarten P. F. Janssen, Laura Peeters, Dominik R. Haudenschild, Andy Cremers, Don A. M. Surtel, Lodewijk W. van Rhijn, Pieter J. Emans, Tim J. M. Welting
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
The generation of cartilage from progenitor cells for the purpose of cartilage repair is often hampered by hypertrophic differentiation of the engineered cartilaginous tissue caused by endochondral ossification. Since a healthy cartilage matrix conta
Externí odkaz:
https://doaj.org/article/36dffda142384c068a95fe5f22f5ffe5
Autor:
Panagiotis Balaskas, Katarzyna Goljanek-Whysall, Peter Clegg, Yongxiang Fang, Andy Cremers, Pieter Emans, Tim Welting, Mandy Peffers
Publikováno v:
International Journal of Genomics, Vol 2017 (2017)
Osteoarthritis (OA) is the most common age-related joint disorder in man. MicroRNAs (miRNA), a class of small noncoding RNAs, are potential therapeutic targets for regulating molecular mechanisms in both disease and ageing. Whilst there is an increas
Externí odkaz:
https://doaj.org/article/a10b242ff1854d83a52ab6df8268a097
Autor:
Guus G H van den Akker, Don A M Surtel, Andy Cremers, Stephen M Richardson, Judith A Hoyland, Lodewijk W van Rhijn, Jan Willem Voncken, Tim J M Welting
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0144497 (2016)
INTRODUCTION:Loss of annulus fibrosus (AF) integrity predisposes to disc herniation and is associated with IVD degeneration. Successful implementation of biomedical intervention therapy requires in-depth knowledge of IVD cell biology. We recently gen
Externí odkaz:
https://doaj.org/article/d9148fedbde842ed99b8cd0e3991ed20