Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Andy, Merritt"'
Autor:
Kayleigh Walker, Roberta Baravalle, Rachel Holyfield, Jacqueline Kalms, Helena Wright, Chitra Seewooruthun, Frederick W. Muskett, Anthony Scott-Tucker, Andy Merritt, Alistair Henry, Alastair D. G. Lawson, Gareth Hall, Christine Prosser, Mark D. Carr
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Interleukin-13 (IL-13) is a cytokine involved in T-cell immune responses and is a well validated therapeutic target for the treatment of asthma, along with other allergic and inflammatory diseases. IL-13 signals through a ternary signalling complex f
Externí odkaz:
https://doaj.org/article/ed60b6efb669458b96fb34943581aadf
Autor:
Stephanie Wills, Ruben Sanchez-Garcia, Tim Dudgeon, Stephen D. Roughley, Andy Merritt, Roderick E. Hubbard, James Davidson, Frank von Delft, Charlotte M. Deane
Publikováno v:
Journal of Chemical Information and Modeling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d6b8b761154cbd4446bcab9359fa0a4
https://doi.org/10.1021/acs.jcim.3c00276
https://doi.org/10.1021/acs.jcim.3c00276
Autor:
Stephanie Wills, Ruben Sanchez-Garcia, Stephen D. Roughley, Andy Merritt, Roderick E. Hubbard, Tim Dudgeon, James Davidson, Frank von Delft, Charlotte M. Deane
Fragment screening using X-ray crystallography can yield rich structural data to help guide the optimization of low-molecular-weight compounds into more potent binders. Fragment merging, whereby substructural motifs from partially overlapping fragmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9463f6dfa4ab4d30a9d919aea047ac6
https://doi.org/10.1101/2022.12.15.520559
https://doi.org/10.1101/2022.12.15.520559
Autor:
Alexander Zhyvoloup, Anat Melamed, Ian Anderson, Delphine Planas, Chen-Hsuin Lee, Janos Kriston-Vizi, Robin Ketteler, Andy Merritt, Jean-Pierre Routy, Petronela Ancuta, Charles R M Bangham, Ariberto Fassati
Publikováno v:
PLoS Pathogens, Vol 13, Iss 7, p e1006460 (2017)
HIV-1 integrates more frequently into transcribed genes, however the biological significance of HIV-1 integration targeting has remained elusive. Using a selective high-throughput chemical screen, we discovered that the cardiac glycoside digoxin inhi
Externí odkaz:
https://doaj.org/article/0b3234340f8f41b2ad4361a5273e369e
Publikováno v:
Journal of chemical information and modeling, vol 62, iss 10
Despite recent interest in deep generative models for scaffold elaboration, their applicability to fragment-to-lead campaigns has so far been limited. This is primarily due to their inability to account for local protein structure or a user’s desig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f8370e6cb54ed5dde04816a4c2d92c
https://pubmed.ncbi.nlm.nih.gov/35499971
https://pubmed.ncbi.nlm.nih.gov/35499971
Autor:
Andy Merritt, Jose Garrido-Mesa, Monika Maciuszek, Timothy M. Chapman, Sanne L. Maas, Oliver Soehnlein, Almudena Ortega-Gomez, Mauro Perretti, Gerry A. F. Nicolaes, Bartolo Ferraro
Publikováno v:
European Journal of Medicinal Chemistry, 226:113805. Elsevier France-Éditions Scientifiques et Medicales Elsevier
A series of Formyl peptide receptor 2 small molecule agonists with a pyrrolidinone scaffold, derived from a combination of pharmacophore modelling and docking studies, were designed and synthesized. The GLASS (GPCR-Ligand Association) database was sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f7bb287416feb2c64142edd6fa1ec5
https://doi.org/10.1016/j.ejmech.2021.113805
https://doi.org/10.1016/j.ejmech.2021.113805
Autor:
Nicole Falci Finardi, HyeongJun Kim, Lee Z. Hernandez, Matthew R. G. Russell, Catherine M-K Ho, Vattipally B. Sreenu, Hannah A. Wenham, Andy Merritt, Blair L. Strang
Publikováno v:
The Journal of General Virology
The shortcomings of current anti-human cytomegalovirus (HCMV) drugs has stimulated a search for anti-HCMV compounds with novel targets. We screened collections of bioactive compounds and identified a range of compounds with the potential to inhibit H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026b318e923bdbedde7b587309efdee2
https://openaccess.sgul.ac.uk/id/eprint/113794/23/jgv001702.pdf
https://openaccess.sgul.ac.uk/id/eprint/113794/23/jgv001702.pdf
Publikováno v:
SLAS Discovery. 24:332-345
Building, curating, and maintaining a compound collection is an expensive operation, beyond the scope of most academic organizations. Here we describe the selection criteria used to compile the LifeArc diversity set from commercial suppliers and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fafcdbb964a1a387c2623dfaed517d4
https://doi.org/10.1177/2472555218803696
https://doi.org/10.1177/2472555218803696
Autor:
Nathalie Bouloc, Kristian Birchall, Andy Merritt, Keith H. Ansell, David A. Baker, Paul W. Bowyer, David Whalley, Simon A. Osborne, Denise J. Tsagris, P.J. Coombs, Ela Smiljanic-Hurley, Jonathan M. Large, Lindsay B. Stewart, Mary C. Wheldon, Catherine A. Kettleborough
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Development of a class of bicyclic inhibitors of the Plasmodium falciparum cyclic GMP-dependent protein kinase (PfPKG), starting from known compounds with activity against a related parasite PKG orthologue, is reported. Examin
Development of a class of bicyclic inhibitors of the Plasmodium falciparum cyclic GMP-dependent protein kinase (PfPKG), starting from known compounds with activity against a related parasite PKG orthologue, is reported. Examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01a5f293ace057b567da68eeb378c47
https://doi.org/10.1016/j.bmcl.2018.11.039
https://doi.org/10.1016/j.bmcl.2018.11.039
Autor:
John G. Mina, Emily A. Dickie, Edubiel A. Alpizar-Sosa, Paul W. Denny, Chris Brown, Maria Paula Gonçalves Borsodi, Cláudia P. Figueiredo, Wenbin Wei, Robson Coutinho-Silva, Douglas O. Escrivani, Emanuelle V. de Lima, Bartira Rossi-Bergmann, Andy Merritt, Amjed Qays Al-Qaisi, Patrick G. Steel, Michael P. Barrett, Rebecca L Charlton, Terry K. Smith
Publikováno v:
ACS infectious diseases, 2021, Vol.7(1), pp.47-63 [Peer Reviewed Journal]
We thank CNPq (PVE Grant: 400894/2014-9 to B.R.-B. and P.G.S.), The Royal Society (The Royal Society International Collaboration Awards for Research Professors 2016: IC160044 to B.R.-B. and P.G.S.), MRC (iCASE studentship for C.B.; Grant MR/M020118/1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68269bc68eb5c08c88f7c95185bf53a9
https://hdl.handle.net/10023/21321
https://hdl.handle.net/10023/21321