Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Andy, G Lynch"'
Autor:
Ermira Lleshi, Toby Milne-Clark, Henson Lee Yu, Henno W. Martin, Robert Hanson, Radoslaw Lach, Sabrina H. Rossi, Anja Lisa Riediger, Magdalena Görtz, Holger Sültmann, Andrew Flewitt, Andy G. Lynch, Vincent J. Gnanapragasam, Charlie E. Massie, Harveer S. Dev
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110330- (2024)
Summary: Prostate cancer screening using prostate-specific antigen (PSA) has been shown to reduce mortality but with substantial overdiagnosis, leading to unnecessary biopsies. The identification of a highly specific biomarker using liquid biopsies,
Externí odkaz:
https://doaj.org/article/e8df49dd662441c084902b69e9243587
Autor:
Katherine Keenan, Kathryn J. Fredricks, Mary Abed Al Ahad, Stella Neema, Joseph R. Mwanga, Mike Kesby, Martha F. Mushi, Annette Aduda, Dominique L. Green, Andy G. Lynch, Sarah I. Huque, Blandina T. Mmbaga, Hannah Worthington, Catherine Kansiime, Emmanuel Olamijuwon, Nyanda E. Ntinginya, Olga Loza, Joel Bazira, Antonio Maldonado-Barragán, VAnne Smith, Arun Gonzales Decano, John Mwaniki Njeru, Alison Sandeman, John Stelling, Alison Elliott, David Aanensen, Stephen H. Gillespie, Gibson Kibiki, Wilber Sabiiti, Derek J. Sloan, Benon B. Asiimwe, John Kiiru, Stephen E. Mshana, Matthew T. G. Holden, HATUA Consortium
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background A key factor driving the development and maintenance of antibacterial resistance (ABR) is individuals’ use of antibiotics (ABs) to treat illness. To better understand motivations and context for antibiotic use we use the concept
Externí odkaz:
https://doaj.org/article/79d95f1658ac4d288983d924be8c008a
Autor:
Claudia Buhigas, Anne Y. Warren, Wing-Kit Leung, Hayley C. Whitaker, Hayley J. Luxton, Steve Hawkins, Jonathan Kay, Adam Butler, Yaobo Xu, Dan J. Woodcock, Sue Merson, Fiona M. Frame, Atef Sahli, Federico Abascal, CRUK-ICGC Prostate Cancer Group, Iñigo Martincorena, G. Steven Bova, Christopher S. Foster, Peter Campbell, Norman J. Maitland, David E. Neal, Charlie E. Massie, Andy G. Lynch, Rosalind A. Eeles, Colin S. Cooper, David C. Wedge, Daniel S. Brewer
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-16 (2022)
Abstract Background Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development. In the present study we applied W
Externí odkaz:
https://doaj.org/article/ab88a2ce376d486096a3008701e9592f
Autor:
Sam Abujudeh, Sebastian S. Zeki, Meta C.J. van Lanschot, Mark Pusung, Jamie M.J. Weaver, Xiaodun Li, Ayesha Noorani, Andrew J. Metz, Jan Bornschein, Lawrence Bower, Ahmad Miremadi, Rebecca C. Fitzgerald, Edward R. Morrissey, Andy G. Lynch
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract Background Somatic copy number alterations (SCNAs) are an important class of genomic alteration in cancer. They are frequently observed in cancer samples, with studies showing that, on average, SCNAs affect 34% of a cancer cell’s genome. F
Externí odkaz:
https://doaj.org/article/38f12a4dfbc9486895c28a273fc43df1
Autor:
Andy G Lynch, Joel Bazira, Derek J Sloan, Catherine Kansiime, Stella Neema, Wilber Sabiiti, Stephen H Gillespie, David M Aanensen, John Stelling, Alison Elliott, Benon B Asiimwe, John Kiiru, Stephen E Mshana, Katherine Keenan, Mike Kesby, Joseph R Mwanga, V Anne Smith, Alison Sandeman, Gibson E Kibiki, Matthew T G Holden, Martha F Mushi, Arun Gonzales Decano, Dominique L Green, John Mwaniki, Nyanda E Ntinginya
Publikováno v:
BMJ Open, Vol 11, Iss 3 (2021)
Introduction Antimicrobial resistance (AMR) is a global health threat that requires urgent research using a multidisciplinary approach. The biological drivers of AMR are well understood, but factors related to treatment seeking and the social context
Externí odkaz:
https://doaj.org/article/b6b437d536c445c8ba073cdded8e82d4
Publikováno v:
Royal Society Open Science, Vol 7, Iss 4 (2020)
The most common way to assess handedness is based on the preferred hand for writing, leading to a binary (left or right) trait. Handedness can also be assessed as a continuous trait with laterality indexes, but these are not time- and cost-effective,
Externí odkaz:
https://doaj.org/article/fa940fe36c774abcb5a2f84c3f3ddd5a
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Abstract Telomere length is a risk factor in disease and the dynamics of telomere length are crucial to our understanding of cell replication and vitality. The proliferation of whole genome sequencing represents an unprecedented opportunity to glean
Externí odkaz:
https://doaj.org/article/925eca9b0f364764afe1780662261112
Autor:
Mohammad Asim, Firas Tarish, Heather I. Zecchini, Kumar Sanjiv, Eleni Gelali, Charles E. Massie, Ajoeb Baridi, Anne Y. Warren, Wanfeng Zhao, Christoph Ogris, Leigh-Anne McDuffus, Patrice Mascalchi, Greg Shaw, Harveer Dev, Karan Wadhwa, Paul Wijnhoven, Josep V. Forment, Scott R. Lyons, Andy G. Lynch, Cormac O’Neill, Vincent R. Zecchini, Paul S. Rennie, Aria Baniahmad, Simon Tavaré, Ian G. Mills, Yaron Galanty, Nicola Crosetto, Niklas Schultz, David Neal, Thomas Helleday
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Tumours with homologous recombination (HR) defects become sensitive to PARPi. Here, the authors show that androgen receptor (AR) regulates HR and AR inhibition activates the PARP pathway in vivo, thus inhibition of both AR and PARP is required for ef
Externí odkaz:
https://doaj.org/article/6dd1f31e993c4c649fd8af898835fe41
Autor:
Tobias Janowitz, Simon Tavaré, Hannah V. Meyer, Andy G. Lynch, Michael A. Bookman, Cameron T. Whitley, Harry Potts, James M.J. Weaver, Nicholas J. Bird, Eva Gablenz, Taehoon Ha, Hassal Lee, Daniel Giglio, Claire M. Connell, Thomas R. Flint, Edward H. Williams
CamGFR v2 App Screenshot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5743f9e0f85ba1afada90a9cde4393f7
https://doi.org/10.1158/1078-0432.22479347
https://doi.org/10.1158/1078-0432.22479347
Autor:
Tobias Janowitz, Simon Tavaré, Hannah V. Meyer, Andy G. Lynch, Michael A. Bookman, Cameron T. Whitley, Harry Potts, James M.J. Weaver, Nicholas J. Bird, Eva Gablenz, Taehoon Ha, Hassal Lee, Daniel Giglio, Claire M. Connell, Thomas R. Flint, Edward H. Williams
Excel file containing Tables S7, S9-15, S18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a39aaebb4d9ed9323d779e06cfc98f2
https://doi.org/10.1158/1078-0432.22479344.v1
https://doi.org/10.1158/1078-0432.22479344.v1