Výsledky vyhledávání - "Andy, Forreryd"

Akademický článek

In Vitro Prediction of Skin-Sensitizing Potency Using the GARDskin Dose–Response Assay: A Simple Regression Approach

Autor: Robin Gradin, Fleur Tourneix, Ulrika Mattson, Johan Andersson, Frédéric Amaral, Andy Forreryd, Nathalie Alépée, Henrik Johansson

Publikováno v: Toxics, Vol 12, Iss 9, p 626 (2024)

Toxicological assessments of skin sensitizers have progressed towards a higher reliance on non-animal methods. Current technological trends aim to extend the utility of non-animal methods to accurately characterize skin-sensitizing potency. The GARDs

Externí odkaz: https://doaj.org/article/92418fb6e0854056a382987a83024b46

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Akademický článek

Quantitative assessment of sensitizing potency using a dose–response adaptation of GARDskin

Autor: Robin Gradin, Andy Forreryd, Ulrika Mattson, Anders Jerre, Henrik Johansson

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Hundreds of chemicals have been identified as skin sensitizers. These are chemicals that possess the ability to induce hypersensitivity reactions in humans, giving rise to a condition termed allergic contact dermatitis. The capacity to limit

Externí odkaz: https://doaj.org/article/25728b4eb9b24df2acacc8780cd8be62

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Akademický článek

Safety Testing of Cosmetic Products: Overview of Established Methods and New Approach Methodologies (NAMs)

Autor: Manon Barthe, Clarisse Bavoux, Francis Finot, Isabelle Mouche, Corina Cuceu-Petrenci, Andy Forreryd, Anna Chérouvrier Hansson, Henrik Johansson, Gregory F. Lemkine, Jean-Paul Thénot, Hanan Osman-Ponchet

Publikováno v: Cosmetics, Vol 8, Iss 2, p 50 (2021)

Cosmetic products need to have a proven efficacy combined with a comprehensive toxicological assessment. Before the current Cosmetic regulation N°1223/2009, the 7th Amendment to the European Cosmetics Directive has banned animal testing for cosmetic

Externí odkaz: https://doaj.org/article/26a0095688fc4c27ab6156c50b30742d

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The GARD™skin assay: Investigation of the applicability domain for metals

Autor: Andy, Forreryd, Robin, Gradin, Olivia, Larne, Nissanka, Rajapakse, Eliot, Deag, Henrik, Johansson

Publikováno v: ALTEX.

New approach methods (NAMs) for hazard identification of skin sensitizing chemicals have been adopted as test guidelines by the OECD during the last decade as alternatives to animal models. These models align to individual key events (KE) in the adve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7503a4dc169a577155f568d617edad
https://pubmed.ncbi.nlm.nih.gov/36343115

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The GARDpotency Assay for Potency-Associated Subclassification of Chemical Skin Sensitizers—Rationale, Method Development, and Ring Trial Results of Predictive Performance and Reproducibility

Autor: Anders Jerre, Robin Gradin, Angelica Johansson, Olivia Larne, Ulrika Mattson, Henrik Johansson, Andy Forreryd, Emil Aaltonen

Publikováno v: Toxicological Sciences

Proactive identification and characterization of hazards attributable to chemicals are central aspects of risk assessments. Current legislations and trends in predictive toxicology advocate a transition from in vivo methods to nonanimal alternatives.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dc5578ac83c92a451373884331304d
http://europepmc.org/articles/PMC7416325

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Exploration of the GARDskin applicability domain: Indirectly acting haptens, hydrophobic substances and UVCBs

Autor: Andy, Forreryd, Robin, Gradin, Charles, Humfrey, Len, Sweet, Henrik, Johansson

Publikováno v: ALTEX.

Hazard assessments of skin sensitizers are increasingly being performed using new approach methodologies (NAMs), with several in chemico, in vitro and most recently also defined approaches (DAs) being accepted for regulatory use. However, keeping tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a244c35a54f63f5c9532a5bbcfcfa1a
https://doi.org/10.14573/altex.2201281

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Akademický článek

Prediction of chemical respiratory sensitizers using GARD, a novel in vitro assay based on a genomic biomarker signature.

Autor: Andy Forreryd, Henrik Johansson, Ann-Sofie Albrekt, Carl A K Borrebaeck, Malin Lindstedt

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0118808 (2015)

Repeated exposure to certain low molecular weight (LMW) chemical compounds may result in development of allergic reactions in the skin or in the respiratory tract. In most cases, a certain LMW compound selectively sensitize the skin, giving rise to a

Externí odkaz: https://doaj.org/article/9e9849c4ff2843fba36df8c50cb0986b

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Quantitative assessment of sensitizing potency using a dose-response adaptation of GARDskin

Autor: Ulrika Mattson, Andy Forreryd, Robin Gradin, Henrik J. Johansson, Anders Jerre

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Hundreds of chemicals have been identified as skin sensitizers. These are chemicals that possess the ability to induce hypersensitivity reactions in humans, giving rise to a condition termed allergic contact dermatitis. The capacity to limit hazardou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca487322b30ccf3c708d490b8d1e2ca1
https://pubmed.ncbi.nlm.nih.gov/34556744

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