Association of Pathogenic Variants in Hereditary Cancer Genes With Multiple Diseases.

Autor: Zeng C; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland., Bastarache LA; Center for Precision Medicine, Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., Tao R; Department of Biostatistics, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee., Venner E; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas., Hebbring S; Center for Human Genetics, Marshfield Clinic Research Institute, Marshfield, Wisconsin., Andujar JD; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Clinical and Translational Hereditary Cancer Program, Division of Genetic Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee., Bland ST; Center for Precision Medicine, Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., Crosslin DR; Department of Biomedical Informatics and Medical Education, University of Washington School of Medicine, Seattle., Pratap S; School of Graduate Studies and Research, Meharry Medical College, Nashville, Tennessee., Cooley A; Department of Microbiology, Immunology and Physiology, Meharry Medical College, Nashville, Tennessee., Pacheco JA; Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois., Christensen KD; PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, Massachusetts.; Department of Population Medicine, Harvard Medical School, Boston, Massachusetts., Perez E; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts., Zawatsky CLB; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts., Witkowski L; Centre Universitaire de Santé McGill, McGill University Health Centre, Montreal, Quebec, Canada., Zouk H; Laboratory for Molecular Medicine, Partners Healthcare Personalized Medicine, Cambridge, Massachusetts.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston., Weng C; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, New York., Leppig KA; Genetic Services and Kaiser Permanente Washington Health Research Institute, Kaiser Permanente of Washington, Seattle., Sleiman PMA; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Division of Human Genetics, Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Division of Human Genetics, Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia., Williams MS; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania., Luo Y; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois., Jarvik GP; Department of Medicine (Medical Genetics), University of Washington, Seattle.; Department of Genome Sciences, University of Washington, Seattle., Green RC; Brigham and Women's Hospital, Broad Institute, Ariadne Labs and Harvard Medical School, Boston, Massachusetts., Chung WK; Department of Pediatrics, Columbia University, New York, New York.; Department of Medicine, Columbia University, New York, New York., Gharavi AG; Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York.; Center for Precision Medicine and Genomics, Department of Medicine, Columbia University Irving Medical Center, New York, New York., Lennon NJ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Rehm HL; Medical & Population Genetics Program and Genomics Platform, Broad Institute of MIT and Harvard Cambridge, Cambridge, Massachusetts.; Center for Genomic Medicine, Massachusetts General Hospital, Boston.; Department of Pathology, Harvard Medical School, Boston, Massachusetts., Gibbs RA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas., Peterson JF; Center for Precision Medicine, Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., Roden DM; Center for Precision Medicine, Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee.; Divisions of Cardiovascular Medicine and Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee., Wiesner GL; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Clinical and Translational Hereditary Cancer Program, Division of Genetic Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee., Denny JC; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.

Publikováno v: JAMA oncology [JAMA Oncol] 2022 Jun 01; Vol. 8 (6), pp. 835-844.