Výsledky vyhledávání - "Andrzej S. Skwarecki"

Akademický článek

Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics – synthesis and properties

Autor: Joanna Stefaniak, Michał G. Nowak, Marek Wojciechowski, Sławomir Milewski, Andrzej S. Skwarecki

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1928-1956 (2022)

Glucosamine-6-phosphate synthase (GlcN-6-P synthase) is known as a promising target for antimicrobial agents and antidiabetics. Several compounds of natural or synthetic origin have been identified as inhibitors of this enzyme. This set comprises hig

Externí odkaz: https://doaj.org/article/efb634eedb7b44cf9e298f4d4ba7d716

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Akademický článek

Fluconazole resistant Candida auris clinical isolates have increased levels of cell wall chitin and increased susceptibility to a glucosamine-6-phosphate synthase inhibitor

Autor: Garima Shahi, Mohit Kumar, Andrzej S. Skwarecki, Matt Edmondson, Atanu Banerjee, Jane Usher, Neil A.R. Gow, Sławomir Milewski, Rajendra Prasad

Publikováno v: The Cell Surface, Vol 8, Iss , Pp 100076- (2022)

In 2009 Candida auris was first isolated as fungal pathogen of human disease from ear canal of a patient in Japan. In less than a decade, this pathogen has rapidly spread around the world and has now become a major health challenge that is of particu

Externí odkaz: https://doaj.org/article/1ad13f1aa7bc4206bde53c1d278273a7

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Akademický článek

Molecular Umbrella as a Nanocarrier for Antifungals

Autor: Andrzej S. Skwarecki, Dorota Martynow, Maria J. Milewska, Sławomir Milewski

Publikováno v: Molecules, Vol 26, Iss 18, p 5475 (2021)

A molecular umbrella composed of two O-sulfated cholic acid residues was applied for the construction of conjugates with cispentacin, containing a “trimethyl lock” (TML) or o-dithiobenzylcarbamoyl moiety as a cleavable linker. Three out of five c

Externí odkaz: https://doaj.org/article/2be785a832ca4fffacfd37f8f5c8d809

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