Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Andrzej Przekwas"'
Autor:
Ross L. Walenga, Clare Butler, Brent A. Craven, P. Worth Longest, Raja Mohamed, Bryan Newman, Bo Olsson, Günther Hochhaus, Bing V. Li, Markham C. Luke, Liang Zhao, Andrzej Przekwas, Robert Lionberger
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 5, Pp 560-574 (2023)
Abstract In silico mechanistic modeling approaches have been designed by various stakeholders with the goal of supporting development and approval of generic orally inhaled drug products in the United States. This review summarizes the presentations
Externí odkaz:
https://doaj.org/article/5c0bae85a62f4563a75d8c48d83d86ce
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
BackgroundBlast induced Traumatic Brain Injury (bTBI) has become a signature casualty of military operations. Recently, military medics observed neurocognitive deficits in servicemen exposed to repeated low level blast (LLB) waves during military hea
Externí odkaz:
https://doaj.org/article/371413d84ea549aba50e852e03fb882b
Autor:
Carrie German, Zhijian Chen, Andrzej Przekwas, Ross Walenga, Andrew Babiskin, Liang Zhao, Jianghong Fan, Ming-Liang Tan
Publikováno v:
Pharmaceutical Research. 40:961-975
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e919144e1ec34bbad5bf1e83c9df5bb5
https://doi.org/10.1007/s11095-023-03480-6
https://doi.org/10.1007/s11095-023-03480-6
Autor:
Ross L. Walenga, Clare Butler, Brent A. Craven, P. Worth Longest, Raja Mohamed, Bryan Newman, Bo Olsson, Günther Hochhaus, Bing V. Li, Markham C. Luke, Liang Zhao, Andrzej Przekwas, Robert Lionberger
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 12:560-574
In silico mechanistic modeling approaches have been designed by various stakeholders with the goal of supporting development and approval of generic orally inhaled drug products in the United States. This review summarizes the presentations and panel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e424b5c22c189ca33b6ad5f4220ebe03
https://doi.org/10.1002/psp4.12889
https://doi.org/10.1002/psp4.12889
Autor:
Kacey Ronaldson-Bouchard, Diogo Teles, Keith Yeager, Daniel Naveed Tavakol, Yimu Zhao, Alan Chramiec, Somnath Tagore, Max Summers, Sophia Stylianos, Manuel Tamargo, Busub Marcus Lee, Susan P. Halligan, Erbil Hasan Abaci, Zongyou Guo, Joanna Jacków, Alberto Pappalardo, Jerry Shih, Rajesh K. Soni, Shivam Sonar, Carrie German, Angela M. Christiano, Andrea Califano, Karen K. Hirschi, Christopher S. Chen, Andrzej Przekwas, Gordana Vunjak-Novakovic
Publikováno v:
Nature Biomedical Engineering. 6:351-371
Engineered tissues can be used to model human pathophysiology and test the efficacy and safety of drugs. Yet, to model whole-body physiology and systemic diseases, engineered tissues with preserved phenotypes need to physiologically communicate. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc30fed8bf7563ff80aa6f1fd15e122
https://doi.org/10.1038/s41551-022-00882-6
https://doi.org/10.1038/s41551-022-00882-6
Publikováno v:
Modeling and Artificial Intelligence in Ophthalmology. 3:10-42
Ocular barriers to drug transport make delivery of effective doses to posterior targets exceptionally difficult. Animal models have commonly been used to evaluate drug distribution and penetrability, but translational tools to determine human dosing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fd12bae1f2413daa3122f8a340f9e63
https://doi.org/10.35119/maio.v3i1.111
https://doi.org/10.35119/maio.v3i1.111
Autor:
Xianlian Alex Zhou, Narender Singh, Andrzej Przekwas, R. Kannan, Ross Walenga, Andrew Babiskin
Publikováno v:
Journal of Computational Design and Engineering
Existing computational models used for simulating the flow and species transport in the human airways are zero-dimensional (0D) compartmental, three-dimensional (3D) computational fluid dynamics (CFD), or the recently developed quasi-3D (Q3D) models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411e37994a3fcba75530ec8967c6bcf8
https://doi.org/10.1093/jcde/qwab008
https://doi.org/10.1093/jcde/qwab008
The complex physiology and anatomy of the lungs and the range of processes involved in pulmonary drug transport and disposition make it challenging to predict the fate of orally inhaled drugs. This study aimed to develop an integrated computational p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e6c8fcd6268743423d6cd3bbb24c603
https://doi.org/10.1101/2022.03.10.483633
https://doi.org/10.1101/2022.03.10.483633
Autor:
Anna Herland, Ben Swenor, Daniel Levner, Olivier Y.F. Henry, Sasan Jalili-Firoozinezhad, Angeliki Chalkiadaki, Henry Sanchez, Andrzej Przekwas, Sauveur S. F. Jeanty, Rachelle Prantil-Baun, Josiah Sliz, Youngjae Choe, Kyung-Jin Jang, Moran Yadid, Susan Marquez, Chris Hinojosa, Thomas C. Ferrante, Blakely B. O'Connor, Tiama Hamkins-Indik, Rachel Fleming, Stephanie Dauth, Janna Nawroth, Morgan Burt, Ben M. Maoz, David B. Chou, Aaron Delahanty, John P. Ferrier, Anthony Bahinski, Jose Fernandez-Alcon, Bret Nestor, Guy Robert Thompson, Lian Leng, Robert Mannix, Michael J. Cronce, Yuka Milton, Mahadevabharath R. Somayaji, Alexandra Sontheimer-Phelps, Tae-Eun Park, Miles Ingram, Edward A. FitzGerald, Debarun Das, Ville J. Kujala, Josue A. Goss, George J. Touloumes, Toni Divic, Carlos F. Ng, Oren Levy, Zachary Tranchemontagne, Elizabeth Calamari, Geraldine A. Hamilton, Alexander Cho, Thomas Grevesse, Norman Wen, Tessa Huffstater, Donald E. Ingber, Kevin Kit Parker, Richard M. Novak
Publikováno v:
Nature Biomedical Engineering. 4:407-420
Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we describe an 'interrogator' that employs liquid-handling robotics, custom s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea94accc104e59d5af0303d98dc1c94f
https://doi.org/10.1038/s41551-019-0497-x
https://doi.org/10.1038/s41551-019-0497-x
Autor:
David B. Chou, Rachelle Prantil-Baun, Ben Swenor, Sasan Jalili-Firoozinezhad, Andrzej Przekwas, Susan Marquez, Tessa Huffstater, Donald E. Ingber, Ben M. Maoz, Anna Herland, Michael J. Cronce, Yuka Milton, Angeliki Chalkiadaki, Miles Ingram, Mahadevabharath R. Somayaji, Alexandra Sontheimer-Phelps, Oren Levy, Sauveur S. F. Jeanty, Richard M. Novak, Aaron Delahanty, Kevin Kit Parker, Debarun Das
Publikováno v:
Nature Biomedical Engineering. 4:421-436
Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD modelling does not provide quantitative PK parameters. Here, we show that physiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ec82bf12b83e9e3677dba09ab7cdb54
https://doi.org/10.1038/s41551-019-0498-9
https://doi.org/10.1038/s41551-019-0498-9