Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Andrzej Piasek"'
1
Myristoylated Derivatives of 2′,3′-didehydro-2′,3′-dideoxythymidine (stavudine) bi-Functional Prodrugs with Potent Anti-HIV-1 Activity and Low Cytotoxicity
Autor: Aleksandra Dąbrowska, Andrzej Lipniacki, Agnieszka Miazga, David Shugar, Tadeusz Kulikowski, Ramendra K. Singh, Andrzej Piasek
Publikováno v: Antiviral Chemistry and Chemotherapy. 23:231-235
Background:To improve in vitro antiviral activity and selectivity of stavudine (d4T), a range of its bi-functional prodrugs, 5′- O-myristoylated derivatives, have been synthesized.Methods:Stavudine 5′- O-myristoylated esters were synthesized usin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea17685f35c8d2bb6e4626bb37b4d7b
https://doi.org/10.3851/imp2679
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2
Aryl H-Phosphonates 17: (N-Aryl)phosphoramidates of Pyrimidine Nucleoside Analogues and Their Synthesis, Selected Properties, and Anti-HIV Activity
Autor: Aleksandra Dąbrowska, Adam Kraszewski, Zofia M. Pietrusiewicz, Joanna Romanowska, Andrzej Guranowski, Marek Figlerowicz, Krystian Kolodziej, Andrzej Piasek, Jerzy Boryski, Jacek Stawinski, Andrzej Lipniacki, Michal Sobkowski, Agnieszka Szymanska-Michalak
Publikováno v: Journal of Medicinal Chemistry. 54:6482-6491
New synthetic protocol for the preparation of nucleoside 5'-(N-aryl)phosphoramidate monoesters 4 was developed. It consisted of a condensation of the corresponding nucleoside 5'-H-phosphonates with aromatic- or heteroaromatic amines promoted by diphe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7991d9f8f0115544d6f9039bb9e2a11e
https://doi.org/10.1021/jm2001103
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3
Synthesis, Biological Properties and Anti-HIV-1 Activity of New Pyrimidine P1,P2-Dinucleotides
Autor: Przemysław Ziemkowski, Tadeusz Kulikowski, Andrzej Piasek, Maria A. Siwecka, Agnieszka Miazga, Andrzej Lipniacki
Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 29:438-444
New homo- and hetero-P(1),P(2)-dinucleotides were prepared with the use of multistep procedures starting from the monophosphates of 3'-fluoro-2-thiothymidine, 3'-fluoro-4-thiothymidine, AZT and 1-[(2-hydroxyethoxy)-methyl-5-propyl-6-phenylselenenyl]u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f9591a1ffda44978ba4466562a63fc
https://doi.org/10.1080/15257771003738642
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4
Synthesis and anti-HIV properties of novel 6-phenylselenenyl-5-propyluracils
Autor: Tadeusz Kulikowski, Krzysztof Felczak, Agnieszka Miazga, Andrzej Lipniacki, Andrzej Piasek, Maria A. Siwecka
Publikováno v: Acta Biochimica Polonica. 54:863-868
Novel 6-phenylselenenyl-5-propyluracils were synthesized from 5-propyluracil with the use of regioselective synthesis to give 1-[(2-hydroxyethoxy)-methyl]-6-phenylselenenyl-5-propyluracil (6), 1-ethoxymethyl-6-phenylselenenyl-5-propyluracil (9) and 1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47ffca781a5beadb443ecb7da2593f9
https://doi.org/10.18388/abp.2007_3189
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5
Aryl H-Phosphonates 18. Synthesis, properties, and biological activity of 2',3'-dideoxynucleoside (N-heteroaryl)phosphoramidates of increased lipophilicity
Autor: Michal Sobkowski, Krystian Kolodziej, Jacek Stawinski, Andrzej Piasek, Jerzy Boryski, Adam Kraszewski, Aleksandra Dabrowska, Andrzej Lipniacki, Joanna Romanowska
Publikováno v: European journal of medicinal chemistry. 100
Recently, AZT (N-pyridyl)phosphoramidates were reported as a new type of potential anti-HIV therapeutics. In continuation of that work, here we present new (N-heteroaryl)phosphoramidate derivatives of antiviral 2′,3′-dideoxynucleosides containing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1073429cf3c23b3dc4fb7ae8d95ddbcd
https://pubmed.ncbi.nlm.nih.gov/26071860
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6
Synthesis and Biological Activity of 1H-benzotriazole and 1H-benzimidazole Analogues — Inhibitors of the NTPase/Helicase of HCV and of Some Related Flaviviridae
Autor: Peter Borowski, Maria Bretner, Anna Schoof, Tadeusz Kulikowski, Andrzej Piasek, Andrea Baier, Katarzyna Kopańska, Andżelika Najda, Michael Reinholz, Andrzej Lipniacki
Publikováno v: Antiviral Chemistry and Chemotherapy. 16:315-326
To improve anti-helical activity of analogues of 1 H-benzotriazole and 1 H-benzimidazole their N-alkyl derivatives were synthesized and tested for anti-helicase activity against enzymes of selected Flaviviridae including hepatitis C virus (HCV), West
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1465b0b8df85f2b447f0faab66f727f8
https://doi.org/10.1177/095632020501600504
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8
Thiated Pyrimidine Deoxynucleoside Analogues, Potential Chemotherapeutic Agents, and Substrates/Inhibitors in Various Enzyme Systems
Autor: Krzysztof Felczak, Alicja K. Drabikowska, Krzysztof Krawiec, Tadeusz Kulikowski, Barbara Gołos, Jarosław Poznański, Maria Bretner, David Shugar, Jolanta M. Dzik, Wojciech Rode, Andrzej Piasek
Publikováno v: Nucleosides and Nucleotides. 16:1295-1299
The synthesis of thated nucleoside and nucleotide analogues, and determination of their structures, conformations, potential chemotherapeutic activities, and substratehnhibitor properties in various enzyme systems, with emphasis on enzymes related to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b17c4541021ca7086f7fc9f1da4dc943
https://doi.org/10.1080/07328319708006174
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9
5′-O-Ester Prodrugs of Potent and Selective Anti-HIV Agent—2′,3′-Dideoxy-3′-fluoro-2-thiothymidine (S2FLT): Synthesis and Anti-HIV Activity
Autor: N. E. Poopeiko, Agnieszka Miazga, M. A. Siweckar, Andrzej Piasek, Tadeusz Kulikowski
Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 22:805-807
Novel synthesis of 2',3'-dideoxy-3'-fluoro-2-thiothymidine (SFLT) based on transformation of appropriately protected 1-beta-D-threo-ribofuranosylthymine is presented. The synthesis and evaluation of SFLT 5'-O-ester prodrugs enzymatic hydrolysis, as w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0cc8cc179f75e01fd36e0bb86e975c
https://doi.org/10.1081/ncn-120022639
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10
Inhibitors of the NTPase/helicases of hepatitis C and related Flaviviridae viruses
Autor: Maria, Bretner, Andzelika, Najda, Romualda, Podwińska, Andrea, Baier, Katarzyna, Paruch, Andrzej, Lipniacki, Andrzej, Piasek, Peter, Borowski, Tadeusz, Kulikowski
Publikováno v: Acta poloniae pharmaceutica.
In the search for inhibitors of the non-structural protein 3 (NS3)-associated NTPase/helicase activities of the hepatitis C virus (HCV), and of the related West Nile Virus (WNV), and Japanese Encephalitis Virus (JEV), random screening of a broad rang
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::46fcba2aa09acb7b619ffb5b30ba58d5
https://pubmed.ncbi.nlm.nih.gov/15909930
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