Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Andrzej Orzeszko"'
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background The protein kinases CK2 and PIM-1 are involved in cell proliferation and survival, the cell cycle, and drug resistance, and they are found overexpressed in virtually all types of human cancer, including breast cancer. In this stud
Externí odkaz:
https://doaj.org/article/526323faf7ee43288639c97874d1193c
Publikováno v:
Molecules, Vol 28, Iss 1, p 147 (2022)
A series of new congeners, 1-[2-(1-adamantyl)ethyl]-1H-benzimidazole (AB) and 1-[2-(1-adamantyl)ethyl]-4,5,6,7-tetrahalogeno-1H-benzimidazole (Hal=Cl, Br, I; tClAB, tBrAB, tIAB), have been synthesized and studied. These novel multi-target ligands com
Externí odkaz:
https://doaj.org/article/6116e938d7e84e378e9660f8d995abfa
Autor:
Monika Janeczko, Zygmunt Kazimierczuk, Andrzej Orzeszko, Andrzej Niewiadomy, Ewa Król, Ryszard Szyszka, Maciej Masłyk
Publikováno v:
Polish Journal of Microbiology, Vol 65, Iss 3 (2016)
A broad series of 4,5,6,7-tetrahalogenated benzimidazoles and 4-(1H-benzimidazol-2-yl)-benzene-1,3-diol derivatives was tested against selected bacteria and fungi. For this study three plant pathogens Colletotrichum sp., Fusarium sp., and Sclerotinia
Externí odkaz:
https://doaj.org/article/94cb749150094b5598c152108e1e1993
Publikováno v:
European Journal of Pharmacology. 820:146-155
Abnormally high levels of CK2 and PIM-1 serine/threonine kinases have been documented in many cases of cancer. The elevation of CK2 and PIM-1 in cells entails suppression of apoptosis and implies a protective role for the kinases against cell death.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659a9793a4b5db860ecc1eb5b7f10c87
https://doi.org/10.1016/j.ejphar.2017.12.018
https://doi.org/10.1016/j.ejphar.2017.12.018
Publikováno v:
Molecular and Cellular Biochemistry
Benzimidazole derivatives of 5,6-dichlorobenzimidazole 1-β-d-ribofuranoside (DRB) comprise the important class of protein kinase CK2 inhibitors. Depending on the structure, benzimidazoles inhibit CK2 with different selectivity and potency. Besides C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef52069388b7888e02a1b02179ef3ae
http://europepmc.org/articles/PMC5290066
http://europepmc.org/articles/PMC5290066
Autor:
Ewa Król, Monika Janeczko, Zygmunt Kazimierczuk, Andrzej Niewiadomy, Maciej Masłyk, Ryszard Szyszka, Andrzej Orzeszko
Publikováno v:
Polish Journal of Microbiology, Vol 65, Iss 3 (2016)
A broad series of 4,5,6,7-tetrahalogenated benzimidazoles and 4-(1H-benzimidazol-2-yl)-benzene-1,3-diol derivatives was tested against selected bacteria and fungi. For this study three plant pathogens Colletotrichum sp., Fusarium sp., and Sclerotinia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017ace476f66f2d59a412225515df798
https://doi.org/10.5604/17331331.1215615
https://doi.org/10.5604/17331331.1215615
Autor:
Zygmunt Kazimierczuk, Lorenzo A. Pinna, Roberto Battistutta, Graziano Lolli, Stefania Sarno, Alessandro Ranchio, Andrzej Orzeszko, Cristina Girardi, Giorgio Cozza, Maria Ruzzene
Publikováno v:
Cellular and Molecular Life Sciences. 71:3173-3185
It has been proposed that dual inhibitors of protein kinases CK2 and PIM-1 are tools particularly valuable to induce apoptosis of cancer cells, a property, however, implying cell permeability, which is lacking in the case of selective CK2/PIM-1 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03fde06a0bb7131ab23e4a4d730ce29f
https://doi.org/10.1007/s00018-013-1552-5
https://doi.org/10.1007/s00018-013-1552-5
Autor:
Andrzej Orzeszko, Agnieszka E. Laudy, Rosa Moo-Puc, Zygmunt Kazimierczuk, Roberto Cedillo-Rivera
Publikováno v:
Journal of Heterocyclic Chemistry. 49:1059-1065
A series of new polyhalogenated benzimidazoles has been synthesized and their antibacterial and antiprotozoal activity was evaluated. Several of new substituted halogenobenzimidazoles and their 2′-deoxynucleosides showed noteworthy antiprotozoal to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d42f9721aa175b1b86489460ebeeeb9b
https://doi.org/10.1002/jhet.936
https://doi.org/10.1002/jhet.936
Autor:
Andrzej Orzeszko, Zygmunt Kazimierczuk, Carolin C. Schneider, Sabine Kartarius, Mathias Montenarh
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:4390-4396
A series of novel CK2 inhibitors, tetrahalogenated benzimidazoles carrying an aminoalkylamino group at position 2, has been prepared by nucleophilic substitution of the respective 2,4,5,6,7-pentabromobenzimidazoles and 2-bromo-4,5,6,7-tetraiodobenzim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406d580e84c58660fa2552ddc697aa4c
https://doi.org/10.1016/j.bmc.2012.05.038
https://doi.org/10.1016/j.bmc.2012.05.038
Autor:
Zygmunt Kazimierczuk, Matthew Elliott, Elena Papinutto, Flavio Meggio, Jenny Bain, Andrzej Orzeszko, Giuseppe Zanotti, Stefania Sarno, Cinzia Franchin, Roberto Battistutta, Lorenzo A. Pinna
Publikováno v:
Current Topics in Medicinal Chemistry. 11:1340-1351
CK2 denotes a pleiotropic, constitutively active protein kinase whose abnormally high level in many cancer cells is held as an example of "non oncogene addiction". A wide spectrum of cell permeable, fairly specific ATP site-directed CK2 inhibitors ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3041667ee037247e677be7d22319d8a6
https://doi.org/10.2174/156802611795589638
https://doi.org/10.2174/156802611795589638