The methods for removal of direct oral anticoagulants and heparins to improve the monitoring of hemostasis: a narrative literature review

Autor: Aleksandra Frackiewicz, Bartlomiej Kalaska, Joanna Miklosz, Andrzej Mogielnicki

Publikováno v: Thrombosis Journal, Vol 21, Iss 1, Pp 1-14 (2023)

Abstract The assessment of hemostasis is necessary to make suitable decisions on the management of patients with thrombotic disorders. In some clinical situations, for example, during thrombophilia screening, the presence of anticoagulants in sample

Externí odkaz: https://doaj.org/article/34d264d6e078401d892e2bda9e812fa5

Cardiovascular and Respiratory Toxicity of Protamine Sulfate in Zebrafish and Rodent Models

Autor: Joanna Miklosz, Bartlomiej Kalaska, Piotr Podlasz, Małgorzata Chmielewska-Krzesińska, Miłosz Zajączkowski, Adam Kosiński, Dariusz Pawlak, Andrzej Mogielnicki

Publikováno v: Pharmaceutics, Vol 13, Iss 3, p 359 (2021)

Protamine sulfate (PS) is the only available option to reverse the anticoagulant activity of unfractionated heparin (UFH), however it can cause cardiovascular and respiratory complications. We explored the toxicity of PS and its complexes with UFH in

Externí odkaz: https://doaj.org/article/7fc22af6465f41648ea4943778785950

Nonclinical evaluation of novel cationically modified polysaccharide antidotes for unfractionated heparin.

Autor: Bartlomiej Kalaska, Kamil Kaminski, Emilia Sokolowska, Dominik Czaplicki, Monika Kujdowicz, Krystyna Stalinska, Joanna Bereta, Krzysztof Szczubialka, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119486 (2015)

Protamine, the only registered antidote of unfractionated heparin (UFH), may produce a number of adverse effects, such as anaphylactic shock or serious hypotension. We aimed to develop an alternative UFH antidote as efficient as protamine, but safer

Externí odkaz: https://doaj.org/article/5ddbab7f7d014d5cb8e4535beec460b0

The effect of ChAdOx1 nCov-19 vaccine on arterial thrombosis development and platelet aggregation in female rats

Autor: Bartlomiej Kalaska, Joanna Miklosz, Justyna Swieton, Aleksandra Jakimczuk, Dariusz Pawlak, Andrzej Mogielnicki

Publikováno v: Vaccine. 40(13)

ChAdOx1 nCoV-19 adenoviral vector vaccine (ChAd) against coronavirus disease 2019 has been associated with vaccine-induced thrombosis and thrombocytopenia (VITT), especially in young women who have presented with unusual localized thrombosis after re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adee6750eeb43ebe03805fdc7e8bf972
https://pubmed.ncbi.nlm.nih.gov/35183388

Reversal Activity and Toxicity of Heparin-Binding Copolymer after Subcutaneous Administration of Enoxaparin in Mice

Autor: Shin-ichi Yusa, Andrzej Mogielnicki, Dariusz Pawlak, Bartlomiej Kalaska, Krzysztof Szczubiałka, Joanna Miklosz, Justyna Swieton

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 20
International Journal of Molecular Sciences, Vol 22, Iss 11149, p 11149 (2021)

Uncontrolled bleeding after enoxaparin (ENX) is rare but may be life-threatening. The only registered antidote for ENX, protamine sulfate (PS), has 60% efficacy and can cause severe adverse side effects. We developed a diblock copolymer, heparin-bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb54aacc249ca6059f4e575217fc57dc