Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Andrzej M. Brzozowski"'
Autor:
Cristina M. Viola, Orsolya Frittmann, Huw T. Jenkins, Talha Shafi, Pierre De Meyts, Andrzej M. Brzozowski
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The insulin-related hormones regulate key life processes in Metazoa, from metabolism to growth, lifespan and aging, through an evolutionarily conserved insulin signalling axis (IIS). In humans the IIS axis is controlled by insulin, two insul
Externí odkaz:
https://doaj.org/article/05681134f42944749a2e698a554ca573
Autor:
Nikolaj Kulahin Roed, Cristina M. Viola, Ole Kristensen, Gerd Schluckebier, Mathias Norrman, Waseem Sajid, John D. Wade, Asser Sloth Andersen, Claus Kristensen, Timothy R. Ganderton, Johan P. Turkenburg, Pierre De Meyts, Andrzej M. Brzozowski
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Insulin-like polypeptide binding proteins (IBPs) from insects can bind diverse insulin-like proteins (ILPs) including human insulin and IGFs. Here, the authors present structures of a Drosophila IBP in its free and ILP-bound forms, providing insights
Externí odkaz:
https://doaj.org/article/ab49da7df68b46db823e2dfac264e41c
Autor:
Petr Pompach, Cristina M. Viola, Jelena Radosavljević, Jingjing Lin, Jiří Jiráček, Andrzej M. Brzozowski, Irena Selicharová
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Structural details of changes accompanying interaction between insulin-related hormones and their binding partners are often enigmatic. Here, cross-linking/mass spectrometry could complement structural techniques and reveal details of these protein-p
Externí odkaz:
https://doaj.org/article/4bd794a741d7415cb3a66a17b4584e79
Autor:
Irena Selicharová, Andrzej M. Brzozowski, Jan Kříž, Petra Dzianová, Lucie Kosinová, Romana Hadravová, Martina Chrudinová, Jiří Jiráček, Pavel Šácha, Pavlo Potalitsyn, Johan P. Turkenburg, Seiya Asai, Lenka Žáková
Publikováno v:
Open Biology, Vol 10, Iss 10 (2020)
Open Biology
Open Biology
Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn 2+ -stabilized oligomers. However, the actual storage forms of this hormone and the impact of zinc ions on insulin production in vivo are
Autor:
Miloš Buděšínský, Václav Vaněk, Irena Selicharová, Michaela Collinsová, Lenka Žáková, Jiří Jiráček, Martina Chrudinová, Kateřina Macháčková, Jan Pícha, Andrzej M. Brzozowski
Publikováno v:
Journal of Medicinal Chemistry. 60:10105-10117
Human insulin-like growth factor 1 (IGF-1) is a 70 amino acid protein hormone, with key impact on growth, development, and lifespan. The physiological and clinical importance of IGF-1 prompted challenging chemical and biological trials toward the dev
Autor:
Cristina M. Viola, Jiří Jiráček, Irena Selicharová, Jelena Radosavljević, Andrzej M. Brzozowski, Jingjing Lin, Petr Pompach
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Frontiers in Endocrinology
Frontiers in Endocrinology
Structural details of changes accompanying interaction between insulin-related hormones and their binding partners are often enigmatic. Here, cross-linking/mass spectrometry could complement structural techniques and reveal details of these protein-p
Autor:
Pavel Jungwirth, Tim Ganderton, Vladimír Palivec, Cristina M. Viola, Elise Duboué-Dijon, Tomáš Křížek, Andrzej M. Brzozowski, Kryštof Březina, Jiří Jiráček
Publikováno v:
Journal of Physical Chemistry B
Journal of Physical Chemistry B, American Chemical Society, 2018, 122 (44), pp.10069-10076. ⟨10.1021/acs.jpcb.8b06557⟩
Journal of Physical Chemistry B, American Chemical Society, 2018, 122 (44), pp.10069-10076. ⟨10.1021/acs.jpcb.8b06557⟩
The oligomeric state of the storage form of human insulin in pancreas, which may be affected by several endogenous components of beta-cells storage granules such as arginine, is not known. Here, the effect of arginine on insulin oligomerisation is in
Autor:
Pavlo Potalitsyn, Irena Selicharová, Jelena Radosavljević, Milan Fábry, Lenka Žáková, Michaela Collinsová, Andrzej M. Brzozowski, Jiří Jiráček, Květoslava Křížková, Kateřina Macháčková, Martina Chrudinová
Publikováno v:
Biochemistry
Insulin-like growth factors 1 and 2 (IGF-1 and -2, respectively) are protein hormones involved not only in normal growth and development but also in life span regulation and cancer. They exert their functions mainly through the IGF-1R or by binding t
Autor:
Johan P. Turkenburg, Emília Kletvíková, Vaclav Veverka, Lenka Žáková, Christopher J. Watson, Andrzej M. Brzozowski, Martin Lepšík, Jiří Jiráček
Publikováno v:
Journal of Biological Chemistry. 288:10230-10240
Despite the recent first structural insight into the insulin-insulin receptor complex, the role of the C terminus of the B-chain of insulin in this assembly remains unresolved. Previous studies have suggested that this part of insulin must rearrange
Autor:
Anette Wärnmark, Eckardt Treuter, Andrzej M. Brzozowski, Ashley C. W. Pike, Jan-Åke Gustafsson, Roderick E. Hubbard
The activation function 2/ligand-dependent interaction between nuclear receptors and their coregulators is mediated by a short consensus motif, the so-called nuclear receptor (NR) box. Nuclear receptors exhibit distinct preferences for such motifs de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea24ad6b317e82079471224df0852af2
https://doi.org/10.1074/jbc.m200764200
https://doi.org/10.1074/jbc.m200764200