Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Andrzej Kolinski"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 162-176 (2020)
Three-dimensional protein structures, whether determined experimentally or theoretically, are often too low resolution. In this mini-review, we outline the computational methods for protein structure reconstruction from incomplete coarse-grained to a
Externí odkaz:
https://doaj.org/article/7286327b639e42e392ec2a88944440c6
Autor:
Mateusz Kurcinski, Maciej Blaszczyk, Maciej Pawel Ciemny, Andrzej Kolinski, Sebastian Kmiecik
Publikováno v:
BioMedical Engineering OnLine, Vol 16, Iss S1, Pp 1-10 (2017)
Abstract Background The characterization of protein–peptide interactions is a challenge for computational molecular docking. Protein–peptide docking tools face at least two major difficulties: (1) efficient sampling of large-scale conformational
Externí odkaz:
https://doaj.org/article/46f032f642314d60a051bb0b65756d64
Autor:
Maciej Pawel Ciemny, Mateusz Kurcinski, Maciej Blaszczyk, Andrzej Kolinski, Sebastian Kmiecik
Publikováno v:
BioMedical Engineering OnLine, Vol 16, Iss S1, Pp 1-9 (2017)
Abstract Background Many protein–protein interactions are mediated by a short linear motif. Usually, amino acid sequences of those motifs are known or can be predicted. It is much harder to experimentally characterize or predict their structure in
Externí odkaz:
https://doaj.org/article/1d1b738cce874b63acd5db6269c79cbd
Publikováno v:
Molecules, Vol 20, Iss 6, Pp 10763-10780 (2015)
Most of the current docking procedures are focused on fine conformational adjustments of assembled complexes and fail to reproduce large-scale protein motion. In this paper, we test a new modeling approach developed to address this problem. CABS-dock
Externí odkaz:
https://doaj.org/article/a6bd41d1815446e59660529cdd6e83e1
Publikováno v:
Molecules, Vol 23, Iss 8, p 1995 (2018)
Protein-peptide interactions play essential roles in many cellular processes and their structural characterization is the major focus of current experimental and theoretical research. Two decades ago, it was proposed to employ the steered molecular d
Externí odkaz:
https://doaj.org/article/3e7771ddfc5b49b3baa26e13d856f305
Publikováno v:
TASK Quarterly, Vol 18, Iss 4 (2014)
Mechanical unfolding of the fourth domain of Distyostelium discoideum filamin (DDFLN4) was studied using a CABS – coarse-grained knowledge-based protein model. Our study demonstrates that CABS is capable of reproducing the unfolding free energy lan
Externí odkaz:
https://doaj.org/article/787b4bc17f3b4c8abd5bf26a91562b2f
Autor:
ANDRZEJ KOLINSKI, SEBASTIAN KMIECIK, MICHAL JAMROZ, MACIEJ BŁASZCZYK, MAKSIM KOUZA, MATEUSZ KURCINSKI
Publikováno v:
TASK Quarterly, Vol 18, Iss 3 (2014)
Theoretical prediction of protein structures and dynamics is essential for understanding the molecular basis of drug action, metabolic and signaling pathways in living cells, designing new technologies in the life science and material sciences. We de
Externí odkaz:
https://doaj.org/article/ff0e72eee8f94cf39d9df15ed6c6a9de
Autor:
Michał, Jamróz, Andrzej, Koliński
Background: The development, optimization and validation of protein modeling methods require efficient tools for structural comparison. Frequently, a large number of models need to be compared with the target native structure. The main reason for the
Externí odkaz:
http://arxiv.org/abs/1302.4000
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 14
International Journal of Molecular Sciences, Vol 22, Iss 7341, p 7341 (2021)
Volume 22
Issue 14
International Journal of Molecular Sciences, Vol 22, Iss 7341, p 7341 (2021)
Most of the protein-protein docking methods treat proteins as almost rigid objects. Only the side-chains flexibility is usually taken into account. The few approaches enabling docking with a flexible backbone typically work in two steps, in which the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88631d030b0abac204ce6775f755d8f