Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Andrzej Kieltyka"'
Publikováno v:
Emergency Medicine News. 40:1
Autor:
Andrzej Kieltyka, Anumeha Singh
Publikováno v:
Emergency Medicine News. 39:1
Autor:
Stéphane De Lombaert, Jianhua Huang, Andrzej Kieltyka, Renee Primus, Yoon Taeyoung, Michael Gulianello, Kevin J. Hodgetts, Dario Doller, Robbin Brodbeck
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2497-2500
The discovery, synthesis and structure–activity studies of a novel series of 2-arylpyrimidin-4-ones as CRF-1 receptor antagonists is described. These compounds are structurally simple and display appropriate physical properties for CNS agents
Autor:
Jack Hammer, He Zhao, Charles J. Manly, Robbin Brodbeck, Renee Primus, Andrzej Kieltyka, Andrew Thurkauf, Jayaraman Chandrasekhar, Stanislaw Rachwal, Xiaoyan Zhang, Kevin J. Hodgetts
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:701-704
5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives were designed, synthesized, and identified as a new series of mixed dopamine D(2)/D(4) receptor antagonists. This series featured a rigid tricyclic ring system as an importa
Autor:
Hutchison Alan J, Kover Renata X, Robbin Brodbeck, Xiao-Shu He, Andrew Thurkauf, Kevin J. Hodgetts, Andrzej Kieltyka, Stanislaw Rachwal, Xiaoyan Zhang, John R. Peterson, Jan W. F. Wasley, Renee J. Primus, He Zhao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3105-3109
Optimization of the lead compound 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihydro-indol-1-yl)-ethanone 1 by systematic structure-activity relation (SAR) studies lead to two potent compounds 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,
Autor:
Xiao-Shu He, Andrew Thurkauf, Andrzej Kieltyka, Jan W. F. Wasley, Robbin Brodbeck, He Zhao, Diane C. Hoffman, Renee J. Primus
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3111-3115
A series of chiral benzylpiperazinyl-1-(2,3-dihydro-indol-1-yl)ethanone derivatives were prepared and examined for their affinity at dopamine D2 and D4 receptors. Three compounds having D2/D4 affinity ratios approximating that found for the atypical
Autor:
Jun Yuan, Andrzej Kieltyka, Robbin Brodbeck, Michael Gulianello, Kevin J. Hodgetts, Stéphane De Lombaert
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2133-2136
The synthesis of a series of 3-aryl pyrazolo[4,3-d]pyrimidines as potential corticotropin-releasing factor (CRF-1) antagonists is described. The effects of substitution on the aromatic ring, the amino group and the pyrazolo ring on CRF-1 receptor bin
6-(4-Benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D4 receptors
Autor:
Jan W. F. Wasley, Kevin J. Hodgetts, Jennifer Tran, Andrew Thurkauf, Robbin Brodbeck, Andrzej Kieltyka
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:3207-3213
A series of novel 6-(4-benzylpiperazin-1-yl)benzodioxanes were prepared and screened at selected dopamine receptor subtypes. 6-(4-[4-Chlorobenzyl]piperazin-1-yl)benzodioxane (2d) had high affinity and selectivity for the D(4) dopamine receptor subtyp
Autor:
and Andrew Thurkauf, Andrzej Kieltyka, Amy Hauck Newman, Michael J. Robarge, Robbin Brodbeck, Stephen M. Husbands
Publikováno v:
Journal of Medicinal Chemistry. 44:3175-3186
The dopamine D3 receptor subtype has been recently targeted as a potential neurochemical modulator of the behavioral actions of psychomotor stimulants, such as cocaine. However, definitive behavioral investigations have been hampered by the lack of h
Autor:
Maria D. Bacolod, Andrew Thurkauf, Xiaoyan Zhang, Andrzej Kieltyka, Jennifer Tran, Jan W. F. Wasley, He Zhao, Robbin Brodbeck, Brian Girard, Kevin J. Hodgetts, Diane C. Hoffman, Kimberly Craven, Stanislaw Rachwal
Publikováno v:
Journal of Medicinal Chemistry. 43:3923-3932
The dopaminergic receptor profile of a series of trans-1-[(2-phenylcyclopropyl)methyl]-4-arylpiperazines was examined. Aromatic substitution patterns were varied with the goal of identifying a compound having affinities for the D(2) and D(4) receptor