Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Andrzej J Rutkowski"'
Autor:
Manivel Lodha, Ihsan Muchsin, Christopher Jürges, Vanda Juranic Lisnic, Anne L'Hernault, Andrzej J Rutkowski, Bhupesh K Prusty, Arnhild Grothey, Andrea Milic, Thomas Hennig, Stipan Jonjic, Caroline C Friedel, Florian Erhard, Lars Dölken
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1010992 (2023)
The genomes of both human cytomegalovirus (HCMV) and murine cytomegalovirus (MCMV) were first sequenced over 20 years ago. Similar to HCMV, the MCMV genome had initially been proposed to harbor ≈170 open reading frames (ORFs). More recently, omics
Externí odkaz:
https://doaj.org/article/ea5dbdd681fa4ad6a528c084c981f79a
Autor:
Thomas Hennig, Marco Michalski, Andrzej J Rutkowski, Lara Djakovic, Adam W Whisnant, Marie-Sophie Friedl, Bhaskar Anand Jha, Marisa A P Baptista, Anne L'Hernault, Florian Erhard, Lars Dölken, Caroline C Friedel
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006954 (2018)
Lytic herpes simplex virus 1 (HSV-1) infection triggers disruption of transcription termination (DoTT) of most cellular genes, resulting in extensive intergenic transcription. Similarly, cellular stress responses lead to gene-specific transcription d
Externí odkaz:
https://doaj.org/article/0b734ce74d4b448b8f8c6a89158cb1cf
Autor:
Thomas D Southgate, Owen J McGinn, Fernanda V Castro, Andrzej J Rutkowski, Mariam Al-Muftah, Georgi Marinov, Graeme J Smethurst, David Shaw, Christopher M Ward, Crispin J Miller, Peter L Stern
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e9982 (2010)
5T4 oncofetal molecules are highly expressed during development and upregulated in cancer while showing only low levels in some adult tissues. Upregulation of 5T4 expression is a marker of loss of pluripotency in the early differentiation of embryoni
Externí odkaz:
https://doaj.org/article/241e25236e374b98aa8b044b9f332cd1
Autor:
Andrzej J. Rutkowski, J. Carl Barrett, Elizabeth A. Harrington, Elena Meuser, Vicky Rowlands, T. Hedley Carr
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Liquid biopsies offer the potential to monitor cancer response and resistance to therapeutics in near real-time. However, the plasma cell free DNA (cfDNA) level can be low and the fraction of circulating tumour DNA (ctDNA) bearing a mutation – lowe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5cc05b2bc4ddda9c7820f71f7c08574
http://link.springer.com/article/10.1038/s41598-019-49043-x
http://link.springer.com/article/10.1038/s41598-019-49043-x
Autor:
Paul J. Lehner, Caroline C. Friedel, Andrea Milic, Lara Djakovic, Florian Erhard, Lars Dölken, Thomas Hennig, Adam W. Whisnant, Arnhild Grothey, Michael Kluge, Sascha Sauer, Marie-Sophie Friedl, Nicholas J Matheson, Somesh Sai, Bhupesh K. Prusty, James C Williamson, Andrzej J. Rutkowski, Ramon Vidal
Publikováno v:
Journal of virology
United States
Journal of Virology
United States
Journal of Virology
The HSV-1 virion host shutoff (vhs) protein efficiently cleaves both host and viral mRNAs in a translation-dependent manner. In this study, we model and quantify changes in vhs activity, as well as virus-induced global loss of host transcriptional ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ba98536a09e2bba57a307c57ff18e5
https://hdl.handle.net/10033/622606
https://hdl.handle.net/10033/622606
Autor:
Paul J. Lehner, Caroline C. Friedel, Sascha Sauer, Ramon Vidal, Andrzej J. Rutkowski, Lara Djakovic, Marie-Sophie Friedl, Somesh Sai, Florian Erhard, James C Williamson, Thomas Hennig, Nicholas J Matheson, Michael Kluge, Bhupesh K. Prusty, Adam W. Whisnant, Lars Dölken
Herpes simplex virus 1 (HSV-1) installs a profound host shut-off during lytic infection. The virion host shut-off (vhs) protein plays a key role in this process by efficiently cleaving both host and viral mRNAs in a translation-initiation-dependent m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73f8877148d4e8518afc2ae29d0f0280
https://doi.org/10.1101/2020.05.20.106039
https://doi.org/10.1101/2020.05.20.106039
Publikováno v:
Nature Communications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::85d64d82cd9ae22c2d804e9169868e9f
Autor:
Florian W. H. Künzig, Thomas Hennig, Markus Landthaler, Paul J. Lehner, Stefan Kempa, Chunguang Liang, Caroline C. Friedel, Christopher S. Jürges, Thomas Dandekar, Florian Erhard, Margarete Göbel, Robin Antrobus, Adam W. Whisnant, Emanuel Wyler, Kristina Döring, Lars Dölken, Chris Bielow, Bhupesh K. Prusty, Anne L’Hernault, Ralf Zimmer, Nicholas J Matheson, Friedrich A. Grässer, Jennifer Menegatti, Guido Mastrobuoni, Andrzej J. Rutkowski
SummarySince the genome of herpes simplex virus 1 (HSV-1) was first sequenced more than 30 years ago, its predicted 80 genes have been intensively studied. Here, we unravel the complete viral transcriptome and translatome during lytic infection with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f611cb225490ef6d491008256de7d4f5
https://doi.org/10.1101/603654
https://doi.org/10.1101/603654
Autor:
Andrzej J. Rutkowski, Lars Dölken
Publikováno v:
Methods in Molecular Biology ISBN: 9781493965168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aaa15da6977a92b213f0da34c00332e
https://doi.org/10.1007/978-1-4939-6518-2_10
https://doi.org/10.1007/978-1-4939-6518-2_10
Autor:
Andrzej J, Rutkowski, Lars, Dölken
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1507
Cellular RNA levels are orchestrated by highly regulated processes involving RNA synthesis (transcription), processing (e.g., splicing, polyadenylation, transport), and degradation. Profiling these changes provides valuable information on the regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d44b3673bde087ed3ccbd3630d709e4
https://pubmed.ncbi.nlm.nih.gov/27832537
https://pubmed.ncbi.nlm.nih.gov/27832537