Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Andrzej Galat"'
Autor:
Andrzej Galat
Publikováno v:
Biomolecules, Vol 9, Iss 2, p 74 (2019)
About 30 years after the discovery of peptidyl-prolyl cis/trans isomerases (PPIases), research on this group of proteins has become somewhat calmer than it used to be, but it still generates lots of interest [...]
Externí odkaz:
https://doaj.org/article/8d4c6d9c9f254d53b8e5b115d670f35f
Autor:
Andrzej Galat
Publikováno v:
Biomolecules, Vol 9, Iss 2, p 59 (2019)
In this technical note, we describe analyses of more than 15,000 sequences of FK506-binding proteins (FKBP) and cyclophilins, also known as peptidyl-prolyl cis/trans isomerases (PPIases). We have developed a novel way of displaying relative changes o
Externí odkaz:
https://doaj.org/article/159538741bae436e80c6904483692a6e
Autor:
Andrzej Galat
Publikováno v:
Biomolecules, Vol 7, Iss 4, p 72 (2017)
Analyses of sequences and structures of the cyclosporine A (CsA)-binding proteins (cyclophilins) and the immunosuppressive macrolide FK506-binding proteins (FKBPs) have revealed that they exhibit peculiar spatial distributions of charges, their overa
Externí odkaz:
https://doaj.org/article/a7357b0813814f889f2992d215725944
Autor:
Marion Doladilhe, Vincent Dive, Olivier Lequin, Pierrick Bruyat, Monika Kaminska, Dimitris Georgiadis, Carole Fruchart Gaillard, Mélissa De Souza, Robert Thai, Evelyne Cassar-Lajeunesse, Carole Malgorn, Laurent Devel, Andrzej Galat, Fabrice Beau, Sarah Bregant, Isabelle Correia
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2021, 60 (33), pp.18272-18279. ⟨10.1002/anie.202106117⟩
Angewandte Chemie International Edition, 2021, 60 (33), pp.18272-18279. ⟨10.1002/anie.202106117⟩
International audience; Activity-based probes enable discrimination between the active enzyme and its inactive or inactivated counterparts. Since metalloproteases catalysis is non-covalent, activity-based probes targeting them have been systematicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71534c08742b02912c580f9fcb997039
https://doi.org/10.1002/ange.202106117
https://doi.org/10.1002/ange.202106117
Autor:
Andrzej, Galat
Publikováno v:
Biomolecules
In this technical note, we describe analyses of more than 15,000 sequences of FK506-binding proteins (FKBP) and cyclophilins, also known as peptidyl-prolyl cis/trans isomerases (PPIases). We have developed a novel way of displaying relative changes o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ddfbac92a23cb25548f0d72e5e886a8
https://pubmed.ncbi.nlm.nih.gov/30754725
https://pubmed.ncbi.nlm.nih.gov/30754725
Autor:
Andrzej Galat
Publikováno v:
Journal of Chemical Information and Modeling. 55:2026-2041
Functional diversity of the three-finger-protein domain (TFPD) had been acquired via hypervariability of some sequence positions and extensive insertion/deletion of short AA-segments that caused multidimensional drift of several sequence attributes s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410ac682749b7fbfca0a9b5426964e93
https://doi.org/10.1021/acs.jcim.5b00322
https://doi.org/10.1021/acs.jcim.5b00322
Autor:
Jacqueline Bua, Andrzej Galat
Publikováno v:
Cellular and Molecular Life Sciences. 67:3467-3488
Cyclosporine A (CsA) is an immunosuppressive cyclic peptide that binds with a high affinity to 18 kDa human cyclophilin-A (hCyPA). CsA and its several natural derivatives have some pharmacological potential in treatment of diverse immune disorders. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe154b18b52b406a99edd91385f2d8c8
https://doi.org/10.1007/s00018-010-0437-0
https://doi.org/10.1007/s00018-010-0437-0
Publikováno v:
FEBS Journal. 275:3207-3225
The three-dimensional structures of some components of snake venoms forming so-called ‘three-fingered protein’ domains (TFPDs) are similar to those of the ectodomains of activin, bone morphogenetic protein and transforming growth factor-β recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c1fba96d764295c9f1ae62624ec4561
https://doi.org/10.1111/j.1742-4658.2008.06473.x
https://doi.org/10.1111/j.1742-4658.2008.06473.x
Autor:
Andrzej Galat
Publikováno v:
Journal of Chemical Information and Modeling. 48:1118-1130
Diverse members of the FK506-binding proteins (FKBPs) group and their complexes with different macrocyclic ligands of fungal origins such as FK506, rapamycin, ascomycin, and their immunosuppressive and nonimmunosuppressive derivatives display a varie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b916b9cb71472903bebafd02509fb81b
https://doi.org/10.1021/ci700429n
https://doi.org/10.1021/ci700429n
Autor:
Andrzej Galat, Francine Bourgeois, Ismahane Guimiot-Maloum, Malik Khelfaoui, Béatrice Levacher, Fabien Guimiot, Virginie Népote, J. M. Moalic, Michel Simonneau, Bernadett Boda, Christophe Mas
Publikováno v:
Gene Expression Patterns. 5:577-585
Neocortical neurons are generated predominantly from the cells that proliferate in the ventricular zone of the telencephalon. In order to understand the nature of these expanding cortical neuronal progenitor cells, we selected by differential display
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b406698bba1103d94f5f95284f687c
https://doi.org/10.1016/j.modgep.2005.03.006
https://doi.org/10.1016/j.modgep.2005.03.006