Zobrazeno 1 - 10
of 309
pro vyhledávání: '"Andrzej, Pilc"'
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2636 (2023)
Major depressive disorder is one of the most severe mental disorders. It strongly impairs daily functioning, and, in extreme cases, it can lead to suicide. Although different treatment options are available for patients with depression, there is an o
Externí odkaz:
https://doaj.org/article/ee1579b6c7704f01b7440ca0560e0bdc
Autor:
Anna Stankiewicz, Katarzyna Kaczorowska, Ryszard Bugno, Aneta Kozioł, Maria H. Paluchowska, Grzegorz Burnat, Barbara Chruścicka, Paulina Chorobik, Piotr Brański, Joanna M. Wierońska, Beata Duszyńska, Andrzej Pilc, Andrzej J. Bojarski
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 211-225 (2022)
Considering the allosteric regulation of mGlu receptors for potential therapeutic applications, we developed a group of 1,2,4-oxadiazole derivatives that displayed mGlu4 receptor positive allosteric modulatory activity (EC50 = 282–656 nM). Selectiv
Externí odkaz:
https://doaj.org/article/986c7044b75f497b83b535e2846fde7c
Autor:
Katarzyna Kaczorowska, Anna Stankiewicz, Ryszard Bugno, Maria H. Paluchowska, Grzegorz Burnat, Piotr Brański, Paulina Cieślik, Joanna M. Wierońska, Mariusz Milik, Mateusz Nowak, Agnieszka Przybyłowicz, Aneta Kozioł, Agata Hogendorf, Adam S. Hogendorf, Justyna Kalinowska-Tłuścik, Beata Duszyńska, Andrzej Pilc, Andrzej J. Bojarski
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 1981 (2023)
Following the glutamatergic theory of schizophrenia and based on our previous study regarding the antipsychotic-like activity of mGlu7 NAMs, we synthesized a new compound library containing 103 members, which were examined for NAM mGlu7 activity in t
Externí odkaz:
https://doaj.org/article/36b1ab318b594487bcb8fddbbc732485
Autor:
Jadwiga Wojkowska-Mach, Brian Godman, Amanda Glassman, Amanj Kurdi, Andrzej Pilc, Anna Rozanska, Szymon Skoczyński, Marta Wałaszek, Tomasz Bochenek
Publikováno v:
Antimicrobial Resistance and Infection Control, Vol 7, Iss 1, Pp 1-10 (2018)
Abstract Background The problem of inappropriate use of antibiotics and the resulting growth in antimicrobial resistance (AMR) has implications for Poland and the world. The objective of this paper was to compare and contrast antibiotic resistance an
Externí odkaz:
https://doaj.org/article/4d0ccaf3c36740c891b583971cbf567f
Effectiveness of fixed-dose combination therapy in hypertension: systematic review and meta-analysis
Publikováno v:
Archives of Medical Science, Vol 14, Iss 5, Pp 1125-1136 (2018)
Externí odkaz:
https://doaj.org/article/bca7e2b62d4246cabcab9d91dd278ee2
Autor:
Ewa Stawowczyk, Krzysztof Piotr Malinowski, Paweł Kawalec, Rafał Bobiński, Jacek Siwiec, Dimitra Panteli, Helene Eckhardt, Steven Simoens, Antònia Agusti, Marc Dooms, Andrzej Pilc
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Objective: To review the reimbursement recommendations issued by selected European health technology assessment agencies for orphan drugs and the reimbursement status of these drugs; to assess the relationship between the type of recommendation and r
Externí odkaz:
https://doaj.org/article/440618f808e04dfa9ef508702e733fe0
Publikováno v:
Acta Poloniae Pharmaceutica - Drug Research. 78:591-598
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35eda3b306ae6361a73a1c588dd8510b
https://doi.org/10.32383/appdr/143279
https://doi.org/10.32383/appdr/143279
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Objective: To assess shares of reimbursed orphan drugs and agreement in reimbursement decision-making in different European Union member states as well as to define odds for reimbursement influenced by the presence of conditional approval or exceptio
Externí odkaz:
https://doaj.org/article/fe5d4fecc29b4ae8a378341a5139b056
Autor:
Paulina Cieślik, Monika Woźniak, Katarzyna Kaczorowska, Piotr Brański, Grzegorz Burnat, Agnieszka Chocyk, Bartosz Bobula, Piotr Gruca, Ewa Litwa, Agnieszka Pałucha-Poniewiera, Agnieszka Wąsik, Andrzej Pilc, Joanna Wierońska
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
The data concerning antipsychotic-like activity of negative allosteric modulators (NAMs)/antagonists of mGlu7 receptors are limited. The only available ligands for this receptor are MMPIP and ADX71743. In the present studies, we used stable cell line
Externí odkaz:
https://doaj.org/article/66f5e82cf27e42e083abcb496054ea7a
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Background: There is conflicting evidence on the impact of biologic treatment on the rate of complications and surgeries in Crohn’s disease (CD). We aimed to assess real-world consequences of biologic treatment of CD.Methods: All adult patients wit
Externí odkaz:
https://doaj.org/article/8b7798ba0bba42508a1f0d2109d27a6a