Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Andrzej, Leś"'
Publikováno v:
Molecules, Vol 28, Iss 20, p 7167 (2023)
We derived a theory of biomolecule binding to the surface of Aun clusters and of the Au plane based on the hard soft acid base (HSAB) principle and the free electron metallic surface model. With the use of quantum mechanical calculations, the chemica
Externí odkaz:
https://doaj.org/article/aa129e197cde4b13a121ca85c54d177d
Autor:
Aviram Trachtenberg, Katarzyna Sidoryk, Somaya Alreate, Suchismita Muduli, Andrzej Leś, Marcin Cybulski, Michael Danilenko
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1517 (2021)
Plant phenolic compounds have shown the ability to cooperate with one another at low doses in producing enhanced anticancer effects. This may overcome the limitations (e.g., poor bioavailability and high-dose toxicity) in developing these agents as c
Externí odkaz:
https://doaj.org/article/fc0aea6bca7c4151b478a93281c8f298
Autor:
Katarzyna Sidoryk, Olga Michalak, Marek Kubiszewski, Andrzej Leś, Marcin Cybulski, Elżbieta U. Stolarczyk, Jan Doubsky
Publikováno v:
Molecules, Vol 25, Iss 15, p 3470 (2020)
An efficient method of thiol group introduction to the structure of common natural products and synthetic active compounds with recognized biological efficacy such genistein (1), 5,11-dimethyl-5H-indolo[2,3-b]quinolin (2), capecitabine (3), diosgenin
Externí odkaz:
https://doaj.org/article/e1b25d934bd14cf2accb05b16388dba9
Autor:
Slawomir Filipek, Olga Michalak, Przemyslaw Miszta, Kinga Trzcińska, Piotr Krzeczyński, Piotr Cmoch, Marcin Cybulski, Pakhuri Mehta, Andrzej Leś
Publikováno v:
The Journal of Organic Chemistry. 86:14321-14332
New acetyl derivatives of uracil, 6-methyluracil, and thymine were obtained in the course of an unconventional synthesis in methylene chloride. It was shown that products with the acetyloxymethyl fragment are formed according to a mechanism different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8979c26496d18df385d9f1e912ce634e
https://doi.org/10.1021/acs.joc.1c00748
https://doi.org/10.1021/acs.joc.1c00748
Autor:
Elżbieta U. Stolarczyk, Marta Łaszcz, Andrzej Leś, Marek Kubiszewski, Krzysztof Kuziak, Katarzyna Sidoryk, Krzysztof Stolarczyk
Publikováno v:
Nanomaterials, Vol 8, Iss 9, p 641 (2018)
The aim of our work was the synthesis and physicochemical characterization of a unique conjugate consisting of gold nanoparticles (AuNPs) and a pharmacologically active anticancer substance abiraterone (AB). The direct coupling of AB with gold consti
Externí odkaz:
https://doaj.org/article/ef02238c43f343a29b549c48adbb04b9
Publikováno v:
Molecules, Vol 23, Iss 1, p 161 (2018)
The molecular structure of capecitabine (a widely applied prodrug of 5-fluorouracil) was studied by multinuclear NMR measurements and DFT quantum mechanical calculations. One or two tautomeric forms in a solution were detected depending on the solven
Externí odkaz:
https://doaj.org/article/22865d4382ef49efa2bacb48351e9fbf
Autor:
Katarzyna Sidoryk, Marta Łaszcz, Weronika Strzempek, Elżbieta Menaszek, Krzysztof Stolarczyk, Elżbieta U. Stolarczyk, Andrzej Leś
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8783, p 8783 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences
Volume 22
Issue 16
Pharmacological and nutraceutical effects of isoflavones, which include genistein (GE), are attributed to their antioxidant activity protecting cells against carcinogenesis. The knowledge of the oxidation mechanisms of an active substance is crucial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ef5ded8fd464abcf51603d4bbb155b
https://www.mdpi.com/1422-0067/22/16/8783
https://www.mdpi.com/1422-0067/22/16/8783
Autor:
Łukasz Nagraba, Katarzyna Buś-Kwaśnik, Monika Filist, Piotr J. Rudzki, Andrzej Leś, Katarzyna Jarus-Dziedzic, Edyta Gilant, Małgorzata Sasinowska-Motyl, Magdalena Bujalska-Zadrożny
Publikováno v:
Pharmacological Reports
Background Magnesium ions (Mg2+) increase and prolong opioid analgesia in chronic and acute pain. The nature of this synergistic analgesic interaction has not yet been explained. Our aim was to investigate whether Mg2+ alter tramadol pharmacokinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba22265dff6976e687159079617e47cb
https://pubmed.ncbi.nlm.nih.gov/33686610
https://pubmed.ncbi.nlm.nih.gov/33686610
The ligand exchange of citrates to thioabiraterone on gold nanoparticles for prostate cancer therapy
Autor:
Elżbieta Menaszek, Marta Łaszcz, Elżbieta U. Stolarczyk, Massimo Fusaro, Andrzej Leś, Katarzyna Sidoryk, Weronika Strzempek, Marek Kubiszewski, Krzysztof Stolarczyk
Cancer is one of the leading causes of morbidity and mortality worldwide and nanotechnology has a significant potential to enhance the therapeutic and diagnostic performance of anti-cancer agents. Our work offers a simple and feasible strategy for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239fdd63d09be61cc69a770c0b0a8dcf
https://ruj.uj.edu.pl/xmlui/handle/item/257644
https://ruj.uj.edu.pl/xmlui/handle/item/257644
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 159:466-476
Two novel high-performance liquid chromatography methods for the determination of process-related impurities of eplerenone drug substance and the designated starting material were developed and validated. Process impurities, including stereoisomers o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187ad8a092cb1934744f09d702da06b2
https://doi.org/10.1016/j.jpba.2018.07.028
https://doi.org/10.1016/j.jpba.2018.07.028