Monitoring of treatment response in IDH-mutant gliomas by assessment of 2-hydroxyglutarate with in-vivo magnetic resonance spectroscopy

Autor: Loebel, F, Bogner, W, Gerstner, ER, Rosen, BR, Chi, AS, Cahill, DP, Andronesi, OC

Publikováno v: 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); 20140511-20140514; Dresden; DOCDI.16.11 /20140513/

Objective: Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2), found in a distinct subset of human gliomas characterized by younger age and improved prognosis, cause marked elevation of the metabolite 2-hydroxyglutarate (2HG). Previous results of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4edc8cd95dc7bdec67f231dec42b430b

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Absolute Metabolite Quantification in Individuals with Glioma and Healthy Individuals Using Whole-Brain Three-dimensional MR Spectroscopic and Echo-planar Time-resolved Imaging.

Autor: Baboli M; From the Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth St, Ste 2301, Charlestown, MA 02129 (M.B., F.W., Z.D., O.C.A.); Harvard Medical School, Boston, Mass (M.B., F.W., Z.D., J.D., E.J.U., T.T.B., D.P.C., O.C.A.); Department of Neurology, Papas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, Mass (J.D.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Mass (E.J.U.); Department of Neurology, Brigham and Women's Hospital, Boston, Mass (T.T.B.); Dana Farber Cancer Institute, Boston, Mass (T.T.B.); and Department of Neurosurgery, Massachusetts General Hospital, Boston, Mass (D.P.C.)., Wang F; From the Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth St, Ste 2301, Charlestown, MA 02129 (M.B., F.W., Z.D., O.C.A.); Harvard Medical School, Boston, Mass (M.B., F.W., Z.D., J.D., E.J.U., T.T.B., D.P.C., O.C.A.); Department of Neurology, Papas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, Mass (J.D.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Mass (E.J.U.); Department of Neurology, Brigham and Women's Hospital, Boston, Mass (T.T.B.); Dana Farber Cancer Institute, Boston, Mass (T.T.B.); and Department of Neurosurgery, Massachusetts General Hospital, Boston, Mass (D.P.C.)., Dong Z; From the Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth St, Ste 2301, Charlestown, MA 02129 (M.B., F.W., Z.D., O.C.A.); Harvard Medical School, Boston, Mass (M.B., F.W., Z.D., J.D., E.J.U., T.T.B., D.P.C., O.C.A.); Department of Neurology, Papas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, Mass (J.D.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Mass (E.J.U.); Department of Neurology, Brigham and Women's Hospital, Boston, Mass (T.T.B.); Dana Farber Cancer Institute, Boston, Mass (T.T.B.); and Department of Neurosurgery, Massachusetts General Hospital, Boston, Mass (D.P.C.)., Dietrich J; From the Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth St, Ste 2301, Charlestown, MA 02129 (M.B., F.W., Z.D., O.C.A.); Harvard Medical School, Boston, Mass (M.B., F.W., Z.D., J.D., E.J.U., T.T.B., D.P.C., O.C.A.); Department of Neurology, Papas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, Mass (J.D.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Mass (E.J.U.); Department of Neurology, Brigham and Women's Hospital, Boston, Mass (T.T.B.); Dana Farber Cancer Institute, Boston, Mass (T.T.B.); and Department of Neurosurgery, Massachusetts General Hospital, Boston, Mass (D.P.C.)., Uhlmann EJ; From the Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth St, Ste 2301, Charlestown, MA 02129 (M.B., F.W., Z.D., O.C.A.); Harvard Medical School, Boston, Mass (M.B., F.W., Z.D., J.D., E.J.U., T.T.B., D.P.C., O.C.A.); Department of Neurology, Papas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, Mass (J.D.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Mass (E.J.U.); Department of Neurology, Brigham and Women's Hospital, Boston, Mass (T.T.B.); Dana Farber Cancer Institute, Boston, Mass (T.T.B.); and Department of Neurosurgery, Massachusetts General Hospital, Boston, Mass (D.P.C.)., Batchelor TT; From the Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth St, Ste 2301, Charlestown, MA 02129 (M.B., F.W., Z.D., O.C.A.); Harvard Medical School, Boston, Mass (M.B., F.W., Z.D., J.D., E.J.U., T.T.B., D.P.C., O.C.A.); Department of Neurology, Papas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, Mass (J.D.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Mass (E.J.U.); Department of Neurology, Brigham and Women's Hospital, Boston, Mass (T.T.B.); Dana Farber Cancer Institute, Boston, Mass (T.T.B.); and Department of Neurosurgery, Massachusetts General Hospital, Boston, Mass (D.P.C.)., Cahill DP; From the Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth St, Ste 2301, Charlestown, MA 02129 (M.B., F.W., Z.D., O.C.A.); Harvard Medical School, Boston, Mass (M.B., F.W., Z.D., J.D., E.J.U., T.T.B., D.P.C., O.C.A.); Department of Neurology, Papas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, Mass (J.D.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Mass (E.J.U.); Department of Neurology, Brigham and Women's Hospital, Boston, Mass (T.T.B.); Dana Farber Cancer Institute, Boston, Mass (T.T.B.); and Department of Neurosurgery, Massachusetts General Hospital, Boston, Mass (D.P.C.)., Andronesi OC; From the Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth St, Ste 2301, Charlestown, MA 02129 (M.B., F.W., Z.D., O.C.A.); Harvard Medical School, Boston, Mass (M.B., F.W., Z.D., J.D., E.J.U., T.T.B., D.P.C., O.C.A.); Department of Neurology, Papas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, Mass (J.D.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Mass (E.J.U.); Department of Neurology, Brigham and Women's Hospital, Boston, Mass (T.T.B.); Dana Farber Cancer Institute, Boston, Mass (T.T.B.); and Department of Neurosurgery, Massachusetts General Hospital, Boston, Mass (D.P.C.).

Publikováno v: Radiology [Radiology] 2024 Sep; Vol. 312 (3), pp. e232401.

ECCENTRIC: a fast and unrestrained approach for high-resolution in vivo metabolic imaging at ultra-high field MR.

Autor: Klauser A; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston.; Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland.; Department of Radiology and Medical Informatics, University of Geneva, Switzerland.; CIBM Center for Biomedical Imaging, Switzerland., Strasser B; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston.; High-Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria., Bogner W; High-Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria., Hingerl L; High-Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria., Courvoisier S; Department of Radiology and Medical Informatics, University of Geneva, Switzerland.; CIBM Center for Biomedical Imaging, Switzerland., Schirda C; Department of Radiology, University of Pittsburgh School of Medicine,Pittsburgh, Pennsylvania, USA., Lazeyras F; Department of Radiology and Medical Informatics, University of Geneva, Switzerland.; CIBM Center for Biomedical Imaging, Switzerland., Andronesi OC; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston.

Publikováno v: ArXiv [ArXiv] 2023 Dec 21. Date of Electronic Publication: 2023 Dec 21.