A carcinogenic trigger to study the function of tumor suppressor genes in Schmidtea mediterranea

Autor: Andromeda Van Roten, Amal Zohir Abo-Zeid Barakat, Annelies Wouters, Thao Anh Tran, Stijn Mouton, Jean-Paul Noben, Luca Gentile, Karen Smeets

Publikováno v: Disease Models & Mechanisms, Vol 11, Iss 9 (2018)

Planarians have been long known for their regenerative ability, which hinges on pluripotency. Recently, however, the planarian model has been successfully established for routine toxicological screens aimed to assess overproliferation, mutagenicity a

Externí odkaz: https://doaj.org/article/5db661c74ca84511a02fc0d13568462c

Planarians Customize Their Stem Cell Responses Following Genotoxic Stress as a Function of Exposure Time and Regenerative State

Autor: Karen Smeets, Andromeda Van Roten, Carmen Franken, Niels Hellings, Gudrun Koppen, An-Sofie Stevens, Nicky Pirotte, Annelies Wouters, Tom Artois, Maxime Willems, Jan-Pieter Ploem, Michelle Plusquin

Aiming to in vivo characterize the responses of pluripotent stem cells and regenerative tissues to carcinogenic stress, we employed the highly regenerative organism Schmidtea mediterranea. Its broad regenerative capacities are attributable to a large

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b62232cdb5eca0701b9b5829bb44bd5
http://hdl.handle.net/1942/26279

Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth

Autor: Nicky Pirotte, Frank Van Belleghem, Andromeda Van Roten, Maxime Willems, Tom Artois, An-Sofie Stevens, Annelies Wouters, Ann Cuypers, Karen Smeets

Publikováno v: Stevens, A-S, Pirotte, N, Wouters, A, Van Roten, A, Van Belleghem, F, Willems, M, Cuypers, A, Artois, T & Smeets, K 2016, ' Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth ', Current Drug Targets, vol. 17, no. 12, pp. 1414-1437 . https://doi.org/10.2174/1389450116666150506112817

A delicate balance exists between the process of carcinogenesis and tissue regeneration. A number of malignant tumours are considered the outcome of an impaired or incomplete regeneration process, resulting in persistently dividing cells. Regeneratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c38ad526e2946766f70ee7a2f807d3b
https://hdl.handle.net/1820/1249b87b-0d55-4a53-823e-c1b9106ed971

Reactive Oxygen Species in Planarian Regeneration

Autor: Francesc Cebrià, Frank Van Belleghem, Nicky Pirotte, Rik Paesen, Susanna Fraguas, Michelle Plusquin, Karen Smeets, Marcel Ameloot, Andromeda Van Roten, Tom Artois, An-Sofie Stevens

Publikováno v: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2015 (2015)
Pirotte, N, Stevens, A-S, Fraguas, S, Plusquin, M, Van Roten, A, Van Belleghem, F, Paesen, R, Ameloot, M, Cebria, F, Artois, T & Smeets, K 2015, ' Reactive Oxygen Species in Planarian Regeneration : An Upstream Necessity for Correct Patterning and Brain Formation ', Oxidative Medicine and Cellular Longevity, vol. 2015, 392476 . https://doi.org/10.1155/2015/392476
Oxidative Medicine and Cellular Longevity, 2015:392476. Hindawi Publishing Corporation

Recent research highlighted the impact of ROS as upstream regulators of tissue regeneration. We investigated their role and targeted processes during the regeneration of different body structures using the planarian Schmidtea mediterranea, an organis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c6904c29484a25e9fc6b90dfd1a3ba
https://hdl.handle.net/1820/957300cd-baba-438c-b120-a49b8540fce5