Výsledky vyhledávání - "Androgen receptor signaling pathway"

Akademický článek

Prostate cancer small extracellular vesicles participate in androgen-independent transformation of prostate cancer by transferring let-7a-5p

Autor: Lin Lei, Lijuan Yu, Weixiao Fan, Xiaoke Hao

Publikováno v: Heliyon, Vol 8, Iss 12, Pp e12114- (2022)

Objectives: Androgen deprivation therapy (ADT) is a standard treatment for advanced prostate cancer (PCa). However, after 2–3 years ADT treatment, prostate cancer inevitably transits from androgen-dependent PCa (ADPC) to androgen-independent PCa (A

Externí odkaz: https://doaj.org/article/c1d6196bb4764b4abf98e03454312ec4

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Construction of enzalutamide-resistant cell model of prostate cancer and preliminary screening of potential drug-resistant genes

Autor: Pengju Guo, Yongguang Jiang, Mingchuan Li, Jiahui Zhao, Qiankun Li, Dechao Wei, Yong Luo, Tao Feng, Xiaobing Yang

Publikováno v: Exp Biol Med (Maywood)

Among many factors of causing castration-resistant prostate cancer (CRPC) progression, a growing number of evidences have shown androgen receptors play a critical role. Therefore, blocking androgen receptor remains a therapeutic goal of CRPC. However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6502bdd0ef9b9f15a0b64492b60fdf87
https://doi.org/10.1177/15353702211012625

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USP26 deubiquitinates androgen receptor (AR) in the maintenance of sperm maturation and spermatogenesis through the androgen receptor signaling pathway

Autor: Jing, Wang, Xia, Zhao, Renyun, Hong

Publikováno v: Advances in Clinical and Experimental Medicine. 29:1153-1160

Background The post-translational modifications of proteins control various physiological and pathological events in cells. Objectives In this study, we investigated the influences of the X-linked deubiquitination enzyme USP26 in mediating androgen r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398369f81af02deb4bcb943fa0c625c6
https://doi.org/10.17219/acem/123355

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Splicing factor PRPF6 upregulates oncogenic androgen receptor signaling pathway in hepatocellular carcinoma

Autor: Huijuan Song, Manlin Wang, Chunyu Wang, Chi Lv, Shengli Wang, Wei Liu, Wensu Liu, Xinping Zhong, Lin Lin, Kai Zeng, Shan Wei, Yue Zhao, Baosheng Zhou, Ning Sun

Publikováno v: Cancer Science

Androgen receptor (AR) signaling is considered to be crucial for the pathogenesis of hepatocellular carcinoma (HCC) with obvious sexual dimorphism. Pre‐mRNA processing factor 6 (PRPF6) was identified as a coactivator of AR. However, the molecular m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472f4d78701891d408bf76c6a8816c73
https://doi.org/10.1111/cas.14595

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Akademický článek

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Phase I clinical trial of HC-1119 soft capsule in Chinese healthy adult male subjects: Pharmacokinetics and safety of single-dose proportionality and effects of food

Autor: Haiping Ma, Tingting Cai, Jianping Xiu, Xin Kang, Tie Zhou, Li Zhang, Song Li, Shouyan Tang, Weidong Xu, Naping Zhao, Shen Gao, Jin Ni

Publikováno v: The Prostate. 82(2)

BACKGROUND Preclinical studies showed that HC-1119, a deuterated version of enzalutamide, could competitively inhibit androgen binding to androgen receptor by blocking the transmission of androgen receptor signaling pathway as enzalutamide, inducing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b2dede6886c4ade8a13914dae4a3df
https://pubmed.ncbi.nlm.nih.gov/34807458

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Metformin mitigates PLCε gene expression and modulates the Notch1/Hes and androgen receptor signaling pathways in castration-resistant prostate cancer xenograft models

Autor: Jianming Pu, Jianguo Tian, Qi Li, Ke Xu, Zhicheng Lu

Publikováno v: Oncology Letters

The present study aimed to establish a mouse model of patient-derived castration-resistant prostate cancer (CRPC) xenograft tumors, and to evaluate the effects of various doses of metformin on phospholipase Ce (PLCe) expression and the neurogenic loc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9431df3b3d0e6cc0449d3c70e96285d
https://pubmed.ncbi.nlm.nih.gov/34429755

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Hypermethylation and Downregulation of UTP6 Are Associated With Stemness Properties, Chemoradiotherapy Resistance, and Prognosis in Rectal Cancer: A Co-expression Network Analysis

Autor: Yong Wu, Yong Peng, Guoxian Guan, Weizhong Jiang, Yiyi Zhang, Xing Liu, Yuanfeng Yang, Jinfu Zhuang, Qiao Gao

Publikováno v: Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)

BackgroundTo identify the hub genes associated with chemoradiotherapy resistance in rectal cancer and explore the potential mechanism.MethodsWeighted gene co-expression network analysis (WGCNA) was performed to identify the gene modules correlated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a555d5848624901b7fbbcbc161ca5d66
https://doi.org/10.3389/fcell.2021.607782

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