Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Andriy Tsupryk"'
Autor:
Reid A. Brennen, Andriy Tsupryk, Roland Zengerle, Varun Raghunathan, Karsten Kraiczek, John T. Mannion, Susan Post
Publikováno v:
Analytical Chemistry. 88:1100-1105
A planar, chip-based flow cell for UV-vis absorbance detection in HPLC is presented. The device features a microfabricated free-standing liquid core waveguide (LCW) capillary detection tube of long path length that is based on total internal reflecti
Autor:
Vera Gorfinkel, Olga Kosobokova, Georgy Gudkov, Marina Tcherevishnik, D. Gavrilov, A. Stepukhovich, Georgy Tyshko, Boris Gorbovitski, Andriy Tsupryk
Publikováno v:
Technical Physics. 53:763-775
A method for characterization and optimization of DNA sequencing systems based on capillary electrophoresis is proposed. A model is developed that relates the read length of a sequencing run and the parameters of DNA sequencing systems such as the pr
Autor:
Boris Gorbovitski, Georgiy Gudkov, D. Gavrilov, I. Tovkach, Olga Kosobokova, Vera Gorfinkel, Andriy Tsupryk, Georgiy Tyshko
Publikováno v:
Biosensors and Bioelectronics. 23:1512-1518
This paper describes design of the new ultra sensitive sensor system for fluorescence detection applications. System comprises two units: optical spectra separation unit and detection unit. Optical unit of the sensor performs spatial spectra separati
Autor:
Vera Gorfinkel, D. Gavrilov, Anatoliy Borodin, Olga Kosobokova, A. Stepukhovich, V.H. Dhulla, Boris Gorbovitski, Georgy Gudkov, Andriy Tsupryk
Publikováno v:
IEEE Journal of Selected Topics in Quantum Electronics. 13:926-933
We present the design, implementation, and characterization of a single-photon counting module (SPCM) based on large-area avalanche photodiode (APD) and new logic circuit based on TTL integrated circuits (ICs) for generating precise quench and reset
Autor:
Vera Gorfinkel, Olga Kosobokova, Boris Gorbovitski, Andriy Tsupryk, D. Gavrilov, Georgiy Tyshko, I. Tovkach, Georgiy Gudkov
Publikováno v:
2008 Conference on Lasers and Electro-Optics.
This paper describes design of the new sensor system for fluorescence detection applications. Based on single photon detection technique proposed system has unique combination of characteristics - high detection speed and wide linearity dynamic range
Publikováno v:
2008 Conference on Lasers and Electro-Optics.
We demonstrate use of silicon photomultipliers (SiPMs) in single photon counting mode for detection of very weak laser induced fluorescence (LIF). Detection of LIF in DNA-sequencing has been performed with three different commercially available SiPMs
Autor:
Nikolai Abanshin, Sergey Pan'kov, Olga Kosobokova, Vyacheslav Khozikov, Georgiy Gudkov, Andriy Tsupryk, Vera Gorfinkel, Olga Somova, Marina Tcherevishnik, Dmitri Gavrilov, Andrey Stepukhovich
Publikováno v:
Electrophoresis. 28(21)
We propose a novel method for electrokinetic injection of DNA samples into capillaries from nanoliter gel micropads, deposited on glass slides, which are coated with electroconducting film. Theoretical and experimental proof is presented for the prop
Autor:
Vera Gorfinkel, Andriy Tsupryk, Dmitri Gavrilov, Marina Tcherevishnik, Andrey Stepukhovich, Georgiy Gudkov, Boris Gorbovitski, Georgiy Tyshko
Publikováno v:
Advanced Photon Counting Techniques.
A multichannel fluorescence detection system for multi-lane DNA sequencer based on single photon counting is presented. The problem of elimination of the lane cross-talk caused by both optical and electronic cross-talk between the detection lanes is
Publikováno v:
Electrophoresis. 27(14)
A novel approach to design and optimize linear multicapillary arrays (LMCAs) for high-throughput DNA sequencing is proposed. A significant increase in the number of capillary lanes is obtained due to the use of composite insertions alternately placed
Autor:
Dmitri Gavrilov, Andriy Tsupryk, Georgiy Gudkov, Olga Kosobokova, Vinit Dhulla, Vera Gorfinkel, Andrey Stepoukhovitch
Publikováno v:
SPIE Proceedings.
Single photon counting is the most sensitive method for detection of weak signals. However, it has rarely been used in DNA sequencing applications because of its complexity. We present a fiberized 16-channel single photon detection (SPD) module based