Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

Autor: Oliver Schnell, Martin J B Taphoorn, Astrid Weyerbrock, Kenneth Aldape, James Perry, Do-Hyun Nam, Roger Stupp, Torsten Pietsch, Wolfgang Wick, Rolf-Dieter Kortmann, Martin J. van den Bent, Andriy Markivskyy, Yong-Kil Hong, Christine Hicking, Louis B. Nabors, Rafal Tarnawski, Benoit Lhermitte, David A. Reardon, Alba A. Brandes, Catherine McBain, Joachim P. Steinbach, Tejpal Gupta, Joerg C. Tonn, László Thurzó, Monika E. Hegi, Thomas Wiegel, Sara Erridge, Martin Picard, Peter Hau, Chae-Yong Kim, Ulrich Herrlinger, Thierry Gorlia, Michael Weller, Chiung-Chyi Shen, Nalini Rao, Krystyna Adamska, Danica Grujicic

Publikováno v: Stupp, R, Hegi, M E, Gorlia, T, Erridge, S C, Perry, J, Hong, Y K, Aldape, K D, Lhermitte, B, Pietsch, T, Grujicic, D, Steinbach, J P, Wick, W, Tarnawski, R, Nam, D H, Hau, P, Weyerbrock, A, Taphoorn, M J B, Shen, C C, Rao, N, Thurzo, L, Herrlinger, U, Gupta, T, Kortmann, R D, Adamska, K, McBain, C, Brandes, A A, Tonn, J C, Schnell, O, Wiegel, T, Kim, C Y, Nabors, L B, Reardon, D A, van den Bent, M J, Hicking, C, Markivskyy, A, Picard, M & Weller, M 2014, ' Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial ', Lancet Oncology, vol. 15, no. 10, pp. 1100-1108 . https://doi.org/10.1016/S1470-2045(14)70379-1
Lancet Oncology, 15(10), 1100-1108. Lancet Publishing Group

Summary Background Cilengitide is a selective αvβ3 and αvβ5 integrin inhibitor. Data from phase 2 trials suggest that it has antitumour activity as a single agent in recurrent glioblastoma and in combination with standard temozolomide chemoradiot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f198e0b59d9b8cfbfd5c5d437a143abd
https://doi.org/10.1016/s1470-2045(14)70379-1