Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Andrii Iakovliev"'
Autor:
Olivia Castellini-Pérez, Elena Povedano, Guillermo Barturen, Manuel Martínez-Bueno, Andrii Iakovliev, Martin Kerick, Raúl López-Domínguez, Concepción Marañón, Javier Martín, Esteban Ballestar, PRECISEADS Clinical Consortium, PRECISEADS Flow Cytometry Study Group, María Orietta Borghi, Weiliang Qiu, Cheng Zhu, Srinivas Shankara, Athina Spiliopoulou, Emanuele de Rinaldis, Elena Carnero-Montoro, Marta E. Alarcón-Riquelme
Publikováno v:
npj Genomic Medicine, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract The heterogeneity of systemic lupus erythematosus (SLE) can be explained by epigenetic alterations that disrupt transcriptional programs mediating environmental and genetic risk. This study evaluated the epigenetic contribution to SLE hetero
Externí odkaz:
https://doaj.org/article/142e1626384c4d3d9b97c0f758239917
Autor:
Andrii Iakovliev, Stuart J. McGurnaghan, Caroline Hayward, Marco Colombo, Debby Lipschutz, Athina Spiliopoulou, Helen M. Colhoun, Paul M. McKeigue
Publikováno v:
Iakovliev, A, McGurnaghan, S J, Hayward, C, Colombo, M, Lipschutz, D, Spiliopoulou, A, Colhoun, H M & McKeigue, P M 2023, ' Genome-wide aggregated trans-effects on risk of type 1 diabetes : A test of the "omnigenic" sparse effector hypothesis of complex trait genetics ', American Journal of Human Genetics, vol. 110, no. 6, pp. 913-926 . https://doi.org/10.1016/j.ajhg.2023.04.003
The "omnigenic" hypothesis postulates that the polygenic effects of common SNPs on a typical complex trait are mediated through trans-effects on expression of a relatively sparse set of effector ("core") genes. We tested this hypothesis in a study of
Publikováno v:
Modern Trends in Structural and Solid Mechanics 1. :17-42
Autor:
Jonathan A. Fallowfield, Archie Campbell, Thomas M Drake, David J. Porteous, Paul R. H. J. Timmers, Ewen M Harrison, Neil C. Henderson, James F. Wilson, Stephen J. Wigmore, Caroline Hayward, Cameron J Fairfield, Nicholas L. Mills, Andrii Iakovliev, Peter K. Joshi, David W. Clark, Robert K. Semple, Athina Spiliopoulou, Prakash Ramachandran, Cathie Sudlow, Riinu Pius, Andrew D. Bretherick, Catherine A Shaw
Publikováno v:
Fairfield, C, Drake, T, Pius, R, Bretherick, A D, Campbell, A, Clark, D, Fallowfield, J A, Hayward, C, Henderson, N C, Iakovliev, A, Joshi, P K, Mills, N L, Porteous, D J, Ramachandran, P, Semple, R K, Shaw, K, Sudlow, C L M, Timmers, P, Wilson, J F, Wigmore, S J, Spiliopoulou, A & Harrison, E M 2021, ' Genome-wide Analysis Identifies Novel Gallstone-susceptibility Loci Including Genes Regulating Gastrointestinal Motility ', Hepatology, pp. 1-33 . https://doi.org/10.1002/hep.32199
ObjectiveGenome-wide association studies (GWAS) have identified several risk loci for gallstone disease. As with most polygenic traits, it is likely many genetic determinants are undiscovered. The aim of this study was to identify novel genetic varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4114c3ecbef36dad3f1dd6eb2106de34
https://doi.org/10.1101/2021.07.16.21260637
https://doi.org/10.1101/2021.07.16.21260637
Autor:
Andrii Iakovliev
Publikováno v:
Вісник НТУУ «КПІ». Машинобудування: збірник наукових праць
Стаття присвячена обговоренню застосування точного методу динамічної матриці жорсткості до проблем пружної стійкості інженерних конс
Publikováno v:
Proceedings of the 2019 9th International Conference on Bioscience, Biochemistry and Bioinformatics.
Fidelity of cell division depends on the ability of an internal cell structure called the mitotic spindle, to maintain the structural integrity of the cellular architecture despite being subject to high compressive loading. We propose a generic softw