Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

Autor: Andrea Strakova, Máire Ní Leathlobhair, Guo-Dong Wang, Ting-Ting Yin, Ilona Airikkala-Otter, Janice L Allen, Karen M Allum, Leontine Bansse-Issa, Jocelyn L Bisson, Artemio Castillo Domracheva, Karina F de Castro, Anne M Corrigan, Hugh R Cran, Jane T Crawford, Stephen M Cutter, Laura Delgadillo Keenan, Edward M Donelan, Ibikunle A Faramade, Erika Flores Reynoso, Eleni Fotopoulou, Skye N Fruean, Fanny Gallardo-Arrieta, Olga Glebova, Rodrigo F Häfelin Manrique, Joaquim JGP Henriques, Natalia Ignatenko, Debbie Koenig, Marta Lanza-Perea, Remo Lobetti, Adriana M Lopez Quintana, Thibault Losfelt, Gabriele Marino, Inigo Martincorena, Simón Martínez Castañeda, Mayra F Martínez-López, Michael Meyer, Berna Nakanwagi, Andrigo B De Nardi, Winifred Neunzig, Sally J Nixon, Marsden M Onsare, Antonio Ortega-Pacheco, Maria C Peleteiro, Ruth J Pye, John F Reece, Jose Rojas Gutierrez, Haleema Sadia, Sheila K Schmeling, Olga Shamanova, Richard K Ssuna, Audrey E Steenland-Smit, Alla Svitich, Ismail Thoya Ngoka, Bogdan A Vițălaru, Anna P de Vos, Johan P de Vos, Oliver Walkinton, David C Wedge, Alvaro S Wehrle-Martinez, Mirjam G van der Wel, Sophie AE Widdowson, Elizabeth P Murchison

Publikováno v: eLife, Vol 5 (2016)

Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have b

Externí odkaz: https://doaj.org/article/06141372134c493a9c7fbb4ad68bc165

Evaluation of cell proliferation and apoptosis markers as predictive factors for electrochemotherapy in cutaneous squamous cell carcinoma of cats

Autor: Roana Cecília S. Ribeiro, Denner S. Anjos, Josiane M. Pazzini, Paulo Henrique L. Bertolo, Gabriel João U. Carra, Andrigo B. De Nardi

Publikováno v: Pesquisa Veterinária Brasileira, Vol 43 (2023)

ABSTRACT: Determining cell proliferation rates and tumor apoptosis through immunohistochemistry allows the evaluation of the biological behavior of the tumor, optimizing the patient’s clinical course. This study aimed to analyze the immunohistochem

Externí odkaz: https://doaj.org/article/83b790b03dfb41ec8a2fa7af6ef1929a

Immunolabelling of Acetylated Histones 3 and 4 and Histone Deacetylases 1, 2 and 6 in Canine Soft Tissue Sarcomas

Autor: Bruna V. Sena, Rodrigo S. Horta, Igor L.S. Senhorello, Oscar R.S. Matiz, Isabela C. Canavari, Larissa M. Souza, Marília G.P.A. Ferreira, Felipe A.R. Sueiro, Mirela T. Costa, Andrigo B. de Nardi

Publikováno v: Journal of comparative pathology. 193

The objective of this study was to investigate the immunolabelling of acetylated histones and histone desacetylase (HDAC) enzymes in canine soft tissue sarcomas (STSs) and to correlate them with histological and clinical features in order to identify

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76fd275acd508b6aabb12004cc25f63
https://pubmed.ncbi.nlm.nih.gov/35487622

Liquid biopsy based on small extracellular vesicles predicts chemotherapy response of canine multicentric lymphomas

Autor: Taismara K. Garnica, Jéssika C. C. Lesbon, Ana C. F. C. M. Ávila, Arina L. Rochetti, Oscar R. S. Matiz, Roana C. S. Ribeiro, Aline Zoppa, Adriana T. Nishiya, Mirela T. Costa, Andrigo B. de Nardi, David J. Argyle, Ricardo F. Strefezzi, Juliano C. Silveira, Heidge Fukumasu

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)

Abstract Lymphoma is the most common type of canine hematological malignancy where the multicentric (cMCL) form accounts for 75% of all cases. The standard treatment is the CHOP chemotherapy protocols that include cyclophosphamide, doxorubicin, vincr

Externí odkaz: https://doaj.org/article/7f611e4eb68c40a7851795778365a7f3

Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer

Autor: Andrea Strakova, Thomas J. Nicholls, Adrian Baez-Ortega, Máire Ní Leathlobhair, Alexander T. Sampson, Katherine Hughes, Isobelle A. G. Bolton, Kevin Gori, Jinhong Wang, Ilona Airikkala-Otter, Janice L. Allen, Karen M. Allum, Clara L. Arnold, Leontine Bansse-Issa, Thinlay N. Bhutia, Jocelyn L. Bisson, Kelli Blank, Cristóbal Briceño, Artemio Castillo Domracheva, Anne M. Corrigan, Hugh R. Cran, Jane T. Crawford, Stephen M. Cutter, Eric Davis, Karina F. de Castro, Andrigo B. De Nardi, Anna P. de Vos, Laura Delgadillo Keenan, Edward M. Donelan, Adela R. Espinoza Huerta, Ibikunle A. Faramade, Mohammed Fazil, Eleni Fotopoulou, Skye N. Fruean, Fanny Gallardo-Arrieta, Olga Glebova, Pagona G. Gouletsou, Rodrigo F. Häfelin Manrique, Joaquim J. G. P. Henriques, Rodrigo S. Horta, Natalia Ignatenko, Yaghouba Kane, Cathy King, Debbie Koenig, Ada Krupa, Steven J. Kruzeniski, Marta Lanza-Perea, Mihran Lazyan, Adriana M. Lopez Quintana, Thibault Losfelt, Gabriele Marino, Simón Martínez Castañeda, Mayra F. Martínez-López, Bedan M. Masuruli, Michael Meyer, Edward J. Migneco, Berna Nakanwagi, Karter B. Neal, Winifred Neunzig, Sally J. Nixon, Antonio Ortega-Pacheco, Francisco Pedraza-Ordoñez, Maria C. Peleteiro, Katherine Polak, Ruth J. Pye, Juan C. Ramirez-Ante, John F. Reece, Jose Rojas Gutierrez, Haleema Sadia, Sheila K. Schmeling, Olga Shamanova, Alan G. Sherlock, Audrey E. Steenland-Smit, Alla Svitich, Lester J. Tapia Martínez, Ismail Thoya Ngoka, Cristian G. Torres, Elizabeth M. Tudor, Mirjam G. van der Wel, Bogdan A. Vițălaru, Sevil A. Vural, Oliver Walkinton, Alvaro S. Wehrle-Martinez, Sophie A. E. Widdowson, Irina Zvarich, Patrick F. Chinnery, Maria Falkenberg, Claes M. Gustafsson, Elizabeth P. Murchison

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

The competitive dynamics of mitochondrial haplotypes juxtaposed within the same cell are poorly studied. Here the authors show, in the context of a transmissible cancer, that one haplotype has recurrently entered cancer cells by horizontal transfer a

Externí odkaz: https://doaj.org/article/cb9d1b65978f4b9aba741090656d7d49