Zobrazeno 1 - 10
of 351
pro vyhledávání: '"Andries, Kalsbeek"'
Autor:
Melanie Modder, Claudia P. Coomans, Dirk-Jan Saaltink, Mayke M. H. Tersteeg, Janna Hoogduin, Leonie Scholten, Amanda C. M. Pronk, Reshma A. Lalai, Anita Boelen, Andries Kalsbeek, Patrick C. N. Rensen, Erno Vreugdenhil, Sander Kooijman
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Crosstalk between peripheral metabolic organs and the central nervous system is essential for body weight control. At the base of the hypothalamus, β-tanycytes surround the portal capillaries and function as gatekeepers to facilitate transf
Externí odkaz:
https://doaj.org/article/dfe49dbfc38e4ce386cd77ee4e307ebf
Autor:
Ayano Shiba, Paul de Goede, Roberta Tandari, Ewout Foppen, Nikita L. Korpel, Tom V. Coopmans, Tom P. Hellings, Merel W. Jansen, Annelou Ruitenberg, Wayne I.G.R. Ritsema, Chun-Xia Yi, Joram D. Mul, Dirk Jan Stenvers, Andries Kalsbeek
Publikováno v:
Neurobiology of Sleep and Circadian Rhythms, Vol 17, Iss , Pp 100106- (2024)
Circadian disruption is an important factor driving the current-day high prevalence of obesity and type-2 diabetes. While the impact of incorrect timing of caloric intake on circadian disruption is widely acknowlegded, the contribution of incorrect t
Externí odkaz:
https://doaj.org/article/9a4fa1a71a80496e91051ba32f866208
Autor:
Floor W. Hiemstra, Dirk Jan Stenvers, Andries Kalsbeek, Evert de Jonge, David J. van Westerloo, Laura Kervezee
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105169- (2024)
Summary: Background: The circadian timing system coordinates daily cycles in physiological functions, including glucose metabolism and insulin sensitivity. Here, the aim was to characterise the 24-h variation in glucose levels in critically ill patie
Externí odkaz:
https://doaj.org/article/ca6c002425664b6696815b2618ecc3f3
Autor:
Felipe Correa-da-Silva, Martin J. Kalsbeek, Femke S. Gadella, Jorn Oppersma, Wei Jiang, Samantha E. C. Wolff, Nikita L. Korpel, Dick F. Swaab, Eric Fliers, Andries Kalsbeek, Chun-Xia Yi
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-13 (2023)
Abstract Evidence from animal experiments has shown that the hypothalamic paraventricular nucleus (PVN) plays a key role in regulating body weight and blood glucose levels. However, it is unclear whether neuron populations in the human PVN are involv
Externí odkaz:
https://doaj.org/article/6857b8695bea4e418b99582681d471fb
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Nocturnal light pollution has been rapidly increasing during the last decades and even though dim artificial light at night (ALAN) has been associated with metabolic diseases, its mechanism is still far from clear. Therefore, the aim of our study was
Externí odkaz:
https://doaj.org/article/e344d5b1778e4e2fbaa51810964d6dac
Autor:
Emmely M de Vries, Hermina C van Beeren, Albert C W A van Wijk, Andries Kalsbeek, Johannes A Romijn, Eric Fliers, Anita Boelen
Publikováno v:
Endocrine Connections, Vol 9, Iss 6, Pp 552-562 (2020)
Fasting induces profound changes in the hypothalamus-pituitary-thyroid axis and peripheral thyroid hormone (TH) metabolism, ultimately leading to lower serum thyroid hormone (TH) concentrations. In the present study, we aimed to investigate the regul
Externí odkaz:
https://doaj.org/article/5b3dfb13c38f4c669fe8c03cd4f3ee01
Autor:
Eleni Angelopoulou, Perrine Inquimbert, Paul Klosen, Greg Anderson, Andries Kalsbeek, Valérie Simonneaux
Publikováno v:
Journal of Circadian Rhythms, Vol 19, Iss 1 (2021)
Female reproductive success relies on proper integration of circadian- and ovarian- signals to the hypothalamic-pituitary-gonadal axis in order to synchronize the preovulatory LH surge at the end of the ovarian follicular stage with the onset of the
Externí odkaz:
https://doaj.org/article/2abc14325dbf42909d89e53b27e9a2cf
Autor:
Xiao-Lan Wang, Samantha E. C. Wolff, Nikita Korpel, Irina Milanova, Cristina Sandu, Patrick C. N. Rensen, Sander Kooijman, Jean-Christophe Cassel, Andries Kalsbeek, Anne-Laurence Boutillier, Chun-Xia Yi
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Microglia are brain immune cells responsible for immune surveillance. Microglial activation is, however, closely associated with neuroinflammation, neurodegeneration, and obesity. Therefore, it is critical that microglial immune response appropriatel
Externí odkaz:
https://doaj.org/article/b87e7dd86024424987a6511a2b35f12c
Autor:
Samantha E. C. Wolff, Xiao-Lan Wang, Han Jiao, Jia Sun, Andries Kalsbeek, Chun-Xia Yi, Yuanqing Gao
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Microglia are the immune cells of the brain. Hyperactivation of microglia contributes to the pathology of metabolic and neuroinflammatory diseases. Evidence has emerged that links the circadian clock, cellular metabolism, and immune activity in micro
Externí odkaz:
https://doaj.org/article/cdc14d7162dd41a78bcab4b8d0be5299
Autor:
Martin J.T. Kalsbeek, Samantha E.C. Wolff, Nikita L. Korpel, Susanne E. la Fleur, Johannes A. Romijn, Eric Fliers, Andries Kalsbeek, Dick F. Swaab, Inge Huitinga, Elly M. Hol, Chun-Xia Yi
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
Animal studies indicate that hypothalamic dysfunction plays a major role in type 2 diabetes mellitus (T2DM) development, and that insulin resistance and inflammation are important mechanisms involved in this disorder. However, it remains unclear how
Externí odkaz:
https://doaj.org/article/b9de5be741634b388701ff71860ba83b