Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Andria Rasile Robinson"'
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48560 (2012)
Heightened production of collagen and other matrix proteins underlies the fibrotic phenotype of systemic sclerosis (SSc). Roscovitine is an inhibitor of cyclin-dependent kinases that promote cell cycling (CDK1, 2), neuronal development (CDK5) and con
Externí odkaz:
https://doaj.org/article/957b0e4eb9d44aa4893754a0b558bcfd
Autor:
Björn Schumacher, Ingrid van der Pluijm, Michael J Moorhouse, Theodore Kosteas, Andria Rasile Robinson, Yousin Suh, Timo M Breit, Harry van Steeg, Laura J Niedernhofer, Wilfred van Ijcken, Andrzej Bartke, Stephen R Spindler, Jan H J Hoeijmakers, Gijsbertus T J van der Horst, George A Garinis
Publikováno v:
PLoS Genetics, Vol 4, Iss 8, p e1000161 (2008)
Mutant dwarf and calorie-restricted mice benefit from healthy aging and unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid syndromes age and die prematurely. To identify mechanisms that regulate mammalian longevity,
Externí odkaz:
https://doaj.org/article/eca5369f81bc4ad7bedd0952aee33ca6
Autor:
Aditi U. Gurkar, Shailaja Allani, Eric E. Kelley, Mariya Muravia, Amanda Webster, Mohammad Fallahi, Xuesen Li, Claudette M. St. Croix, Yuxiang Cui, Andria Rasile Robinson, Yinsheng Wang, Laura J. Niedernhofer, Herbert Weissbach, Paul D. Robbins, Matthew S. Gill
Publikováno v:
Redox Biology
Redox Biology, Vol 18, Iss, Pp 191-199 (2018)
Redox Biology, Vol 18, Iss, Pp 191-199 (2018)
DNA damage is presumed to be one type of stochastic macromolecular damage that contributes to aging, yet little is known about the precise mechanism by which DNA damage drives aging. Here, we attempt to address this gap in knowledge using DNA repair-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4f0be73cc015d8a69ea21e8fc4e537
https://doi.org/10.1016/j.redox.2018.06.005
https://doi.org/10.1016/j.redox.2018.06.005
Autor:
Aditi U. Gurkar, Małgorzata Nowak, Jolanta Czerwińska, Dorota Dziuban-Lech, Elżbieta Speina, Jarosław M. Cieśla, Barbara Tudek, Anna Barańczyk-Kuźma, Konrad Kosicki, Daria Kołata, Ryszard Olinski, Hillary L. Shane, Lora H. Rigatti, Patrycja Wojtczak, Małgorzata Bednarek, Beata Gajewska, Matthew J. Yousefzadeh, Ewelina Zarakowska, Daniel Gackowski, Siobhán Q. Gregg, Andria Rasile Robinson, Sara J. McGowan, Laura J. Niedernhofer
Publikováno v:
Free Radical Biology and Medicine. 124:79-96
Lipid peroxidation (LPO) products are relatively stable and abundant metabolites, which accumulate in tissues of mammals with aging, being able to modify all cellular nucleophiles, creating protein and DNA adducts including crosslinks. Here, we used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4531404d6bb1263216926690c73cf8f2
https://doi.org/10.1016/j.freeradbiomed.2018.05.088
https://doi.org/10.1016/j.freeradbiomed.2018.05.088
Autor:
Christin E. Burd, Christy E. Trussoni, Lora H. Rigatti, Jin Wang, Matthew J. Yousefzadeh, Jolanta Czerwińska, Luigi Aurelio Nasto, Erin M. Skoda, Jamie B. Harris, Tania A. Rozgaja, Caroline H. Johnson, Heike Fuhrmann-Stroissnigg, Paul D. Robbins, Renã A. S. Robinson, Nathan A. Yates, Donna B. Stolz, Aditi U. Gurkar, Eric E. Kelley, Simon C. Watkins, Jeremy S. Tilstra, Gary Siuzdak, Marie-Céline Frantz, Harris Bell-Temin, Nam Vo, Patrick J. Pagano, Peter Wipf, Hannah Pope-Varsalona, Siobhán Q. Gregg, Xuesen Li, Sara J. McGowan, Patricia L. Opresko, Nicholas F. LaRusso, Eugenia Cifuentes-Pagano, Claudette M. St. Croix, Nadiezhda Cantu-Medellin, Chelsea H. Feldman, Andria Rasile Robinson, Yinsheng Wang, Laura J. Niedernhofer, Salony Maniar, Mark A. Ross, Barbara Tudek
Publikováno v:
Redox Biology, Vol 17, Iss, Pp 259-273 (2018)
Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if spontaneous nuclear DNA damage is sufficient to initiate se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8de342bc118640c4df5313622d782b
https://pubmed.ncbi.nlm.nih.gov/29747066
https://pubmed.ncbi.nlm.nih.gov/29747066
Autor:
Tania A. Rozgaja, Georgia Chatzinikolaou, George A. Garinis, Sandra Siakouli, Irene Kamileri, Andria Rasile Robinson, Laura J. Niedernhofer, Eleni Vergadi, Theodoros Kosteas, Iannis Tsamardinos, Ismene Karakasilioti, Christos Tsatsanis
Publikováno v:
Cell Metabolism. 18(3):403-415
SummaryLipodystrophies represent a group of heterogeneous disorders characterized by loss of fat tissue. However, the underlying mechanisms remain poorly understood. Using mice carrying an ERCC1-XPF DNA repair defect systematically or in adipocytes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6baa09efe9450d4a15d9ce47ba54cc
Publikováno v:
Stem Cells. 31:511-525
Daily, cells incur tens of thousands of DNA lesions caused by endogenous processes. Due to their long-lived nature, adult stem cells may be particularly susceptible to the negative impact of this constant genotoxic stress. Indeed, in murine models of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4b7d83ed894eb583773761be851b35
https://doi.org/10.1002/stem.1261
https://doi.org/10.1002/stem.1261
Autor:
Cheryl L. Clauson, Gwendolyn Sowa, James Kang, Peter Wipf, Nam Vo, Enrico Pola, Luigi Aurelio Nasto, Qing Dong, Laura J. Niedernhofer, Claudette M. St. Croix, Andria Rasile Robinson, Paul D. Robbins, Kevin Ngo
Publikováno v:
Journal of Orthopaedic Research. 31:1150-1157
Oxidative damage is a well-established driver of aging. Evidence of oxidative stress exists in aged and degenerated discs, but it is unclear how it affects disc metabolism. In this study, we first determined whether oxidative stress negatively impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5148d4b0cbbc8dc408b109e490365981
https://doi.org/10.1002/jor.22320
https://doi.org/10.1002/jor.22320
Autor:
Christoph Maier, Laura J. Niedernhofer, Anil V. Parwani, Diana Sisca Harya, Veronica Yao, Andria Rasile Robinson, Dean J. Bacich, Derek J. Matoka, Jennifer L. Gregg
Publikováno v:
The Prostate. 72:1214-1222
Background The excision repair cross complementing (ERCC1) gene product plays a vital role in the nucleotide excision repair and DNA interstrand crosslink repair pathways, which protect the genome from mutations and chromosomal aberrations, respectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed804f2c071352599ccdccab07d01f3c
https://doi.org/10.1002/pros.22472
https://doi.org/10.1002/pros.22472
Publikováno v:
DNA Repair. 10:781-791
ERCC1-XPF is a structure-specific endonuclease required for nucleotide excision repair, interstrand crosslink repair, and the repair of some double-strand breaks. Mutations in ERCC1 or XPF cause xeroderma pigmentosum, XFE progeroid syndrome or cerebr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20fa59304dde2dcaf45b6b86faf68a5
https://doi.org/10.1016/j.dnarep.2011.04.026
https://doi.org/10.1016/j.dnarep.2011.04.026