Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Andrey Y Abramov"'
Autor:
Charles Arber, Plamena R Angelova, Sarah Wiethoff, Yugo Tsuchiya, Francesca Mazzacuva, Elisavet Preza, Kailash P Bhatia, Kevin Mills, Ivan Gout, Andrey Y Abramov, John Hardy, James A Duce, Henry Houlden, Selina Wray
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184104 (2017)
Mutations in PANK2 lead to neurodegeneration with brain iron accumulation. PANK2 has a role in the biosynthesis of coenzyme A (CoA) from dietary vitamin B5, but the neuropathological mechanism and reasons for iron accumulation remain unknown. In this
Externí odkaz:
https://doaj.org/article/f5f6c31baff54e20bd2c981bf542ab13
Autor:
Ross A Breckenridge, Izabela Piotrowska, Keat-Eng Ng, Timothy J Ragan, James A West, Surendra Kotecha, Norma Towers, Michael Bennett, Petra C Kienesberger, Ryszard T Smolenski, Hillary K Siddall, John L Offer, Mihaela M Mocanu, Derek M Yelon, Jason R B Dyck, Jules L Griffin, Andrey Y Abramov, Alex P Gould, Timothy J Mohun
Publikováno v:
PLoS Biology, Vol 11, Iss 9, p e1001666 (2013)
Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited. Myocardial oxygen consumption is determined by regulation of energy metabolism, wh
Externí odkaz:
https://doaj.org/article/c94bc252bb4048fdb56691e64de2627d
Autor:
Pia A Elustondo, Plamena R Angelova, Michał Kawalec, Michał Michalak, Piotr Kurcok, Andrey Y Abramov, Evgeny V Pavlov
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75812 (2013)
Poly(3-hydroxybutyrate) (PHB) is a polyester of 3-hydroxybutyric acid (HB) that is ubiquitously present in all organisms. In higher eukaryotes PHB is found in the length of 10 to 100 HB units and can be present in free form as well as in association
Externí odkaz:
https://doaj.org/article/f288c9cdd3454007a2f3516f24394322
Publikováno v:
Antioxidants, Vol 13, Iss 9, p 1121 (2024)
Despite recent technological progress, carbon monoxide poisoning is still one of the leading causes of domestic and industrial morbidity and mortality. The brain is particularly vulnerable to CO toxicity, and thus the majority of survivors develop de
Externí odkaz:
https://doaj.org/article/8ba9d6a7a700444a9e00e8834082249d
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37564 (2012)
BACKGROUND:Parkinson's disease is a common neurodegenerative disease characterised by progressive loss of dopaminergic neurons, leading to dopamine depletion in the striatum. Mutations in the PINK1 gene cause an autosomal recessive form of Parkinson'
Externí odkaz:
https://doaj.org/article/ff9400d3c1844492a2df3642e5e7fc42
Autor:
Natalia Igosheva, Andrey Y Abramov, Lucilla Poston, Judith J Eckert, Tom P Fleming, Michael R Duchen, Josie McConnell
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10074 (2010)
The negative impact of obesity on reproductive success is well documented but the stages at which development of the conceptus is compromised and the mechanisms responsible for the developmental failure still remain unclear. Recent findings suggest t
Externí odkaz:
https://doaj.org/article/ba34669e199a4ecda526410553580cff
Autor:
Alison Wood-Kaczmar, Sonia Gandhi, Zhi Yao, Andrey Y Abramov, Erik A Miljan, Gregory Keen, Lee Stanyer, Iain Hargreaves, Kristina Klupsch, Emma Deas, Julian Downward, Louise Mansfield, Parmjit Jat, Joanne Taylor, Simon Heales, Michael R Duchen, David Latchman, Sarah J Tabrizi, Nicholas W Wood
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2455 (2008)
Parkinson's disease (PD) is a common age-related neurodegenerative disease and it is critical to develop models which recapitulate the pathogenic process including the effect of the ageing process. Although the pathogenesis of sporadic PD is unknown,
Externí odkaz:
https://doaj.org/article/e6f71b48d51e401d9ebca115efdfb402
Autor:
Andrey Y. Vinokurov, Marina Y. Pogonyalova, Larisa Andreeva, Andrey Y. Abramov, Plamena R. Angelova
Publikováno v:
Current Research in Pharmacology and Drug Discovery, Vol 6, Iss , Pp 100187- (2024)
Alteration of mitochondrial metabolism by various mutations or toxins leads to various neurological conditions. Age-related changes in energy metabolism could also play the role of a trigger for neurodegenerative disorders. Nonetheless, it is not cle
Externí odkaz:
https://doaj.org/article/a098f1d47ee0433fb184e2d3dc30abc0
Autor:
Isabel N. Christie, Shefeeq M. Theparambil, Alice Braga, Maxim Doronin, Patrick S. Hosford, Alexey Brazhe, Alexander Mascarenhas, Shereen Nizari, Anna Hadjihambi, Jack A. Wells, Adrian Hobbs, Alexey Semyanov, Andrey Y. Abramov, Plamena R. Angelova, Alexander V. Gourine
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113514- (2023)
Summary: During hypoxia, increases in cerebral blood flow maintain brain oxygen delivery. Here, we describe a mechanism of brain oxygen sensing that mediates the dilation of intraparenchymal cerebral blood vessels in response to reductions in oxygen
Externí odkaz:
https://doaj.org/article/e103ac5e3e2a45a0b6df0577e2df1764
Autor:
Artyom Y. Baev, Andrey Y. Vinokurov, Elena V. Potapova, Andrey V. Dunaev, Plamena R. Angelova, Andrey Y. Abramov
Publikováno v:
Cells, Vol 13, Iss 7, p 648 (2024)
Neurodegenerative diseases are chronic conditions occurring when neurons die in specific brain regions that lead to loss of movement or cognitive functions. Despite the progress in understanding the mechanisms of this pathology, currently no cure exi
Externí odkaz:
https://doaj.org/article/4fac893392b44e4994f77401b8f77550