Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Andrey V. Markov"'
Autor:
Kirill V. Odarenko, Aleksandra V. Sen’kova, Oksana V. Salomatina, Oleg V. Markov, Nariman F. Salakhutdinov, Marina A. Zenkova, Andrey V. Markov
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Soloxolone amides are semisynthetic triterpenoids that can cross the blood-brain barrier and inhibit glioblastoma growth both in vitro and in vivo. Here we investigate the impact of these compounds on processes associated with glioblastoma invasivene
Externí odkaz:
https://doaj.org/article/8bda56d571fa47af9a22c1eedf902d68
Autor:
Arseny D. Moralev, Oksana V. Salomatina, Ivan V. Chernikov, Nariman F. Salakhutdinov, Marina A. Zenkova, Andrey V. Markov
Publikováno v:
ACS Omega, Vol 8, Iss 51, Pp 48813-48824 (2023)
Externí odkaz:
https://doaj.org/article/97f53e210b5b4b3c8c867f70daf22953
Autor:
Arseny D. Moralev, Oksana V. Salomatina, Nariman F. Salakhutdinov, Marina A. Zenkova, Andrey V. Markov
Publikováno v:
Molecules, Vol 29, Iss 20, p 4939 (2024)
Multidrug resistance (MDR) remains a significant challenge in cancer therapy, primarily due to the overexpression of transmembrane drug transporters, with P-glycoprotein (P-gp) being a central focus. Consequently, the development of P-gp inhibitors h
Externí odkaz:
https://doaj.org/article/99f440c0327c4dca97ff2cc2a61798c4
Autor:
Kirill V. Odarenko, Oksana V. Salomatina, Ivan V. Chernikov, Nariman F. Salakhutdinov, Marina A. Zenkova, Andrey V. Markov
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1369 (2023)
Despite the proven tumorigenic effect of leptin on epithelial-derived cancers, its impact on the aggressiveness of neural crest-derived cancers, notably neuroblastoma, remains largely unexplored. In our study, for the first time, transcriptome analys
Externí odkaz:
https://doaj.org/article/bb9693f1040e4e129c5b5696f6b6a6ab
Autor:
Andrey V. Markov, Anna A. Ilyina, Oksana V. Salomatina, Aleksandra V. Sen’kova, Alina A. Okhina, Artem D. Rogachev, Nariman F. Salakhutdinov, Marina A. Zenkova
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 603 (2022)
The modification of natural or semisynthetic triterpenoids with amines can be explored as a promising strategy for improving their pharmacological properties. Here, we report the design and synthesis of 11 novel amide derivatives of soloxolone methyl
Externí odkaz:
https://doaj.org/article/0e236ee1d7d643448b1ea349a90beec2
Autor:
Islam Saber Ead Mohamed, Aleksandra V. Sen’kova, Oleg V. Markov, Andrey V. Markov, Innokenty A. Savin, Marina A. Zenkova, Nadezhda L. Mironova
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1173 (2022)
In this investigation, we extensively studied the mechanism of antitumor activity of bovine pancreatic RNase A. Using confocal microscopy, we show that after RNase A penetration into HeLa and B16 cells, a part of the enzyme remains unbound with the r
Externí odkaz:
https://doaj.org/article/3f3cae006e2e4858bf3bff7765acd96c
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 1017 (2022)
Asthma is a heterogeneous pulmonary disorder, the progression and chronization of which leads to airway remodeling and fibrogenesis. To understand the molecular mechanisms of pulmonary fibrosis development, key genes forming the asthma-specific regul
Externí odkaz:
https://doaj.org/article/db6c615ac318438cafbe81a1f3a41be4
Autor:
Andrey V. Markov, Alexandra V. Sen’kova, Dawid Warszycki, Oksana V. Salomatina, Nariman F. Salakhutdinov, Marina A. Zenkova, Evgeniya B. Logashenko
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Highly pathogenic influenza viruses pose a serious public health threat to humans. Although vaccines are available, new antivirals are needed to efficiently control disease progression and virus transmission due to the emergence of drug-resi
Externí odkaz:
https://doaj.org/article/ea4e8d5e87eb4582ac88be3f232b7d9f
Autor:
Andrey V. Markov, Kirill V. Odarenko, Aleksandra V. Sen’kova, Oksana V. Salomatina, Nariman F. Salakhutdinov, Marina A. Zenkova
Publikováno v:
Molecules, Vol 25, Iss 24, p 5925 (2020)
Introduction of α-cyano α,β-unsaturated carbonyl moiety into natural cyclic compounds markedly improves their bioactivities, including inhibitory potential against tumor growth and metastasis. Previously, we showed that cyano enone-bearing derivat
Externí odkaz:
https://doaj.org/article/fe1ef1dd4ffb4c038923830999f87484
Autor:
Islam Saber Ead Mohamed, Aleksandra V. Sen’kova, Alsu I. Nadyrova, Innokenty A. Savin, Andrey V. Markov, Vladimir A. Mitkevich, Aleksander A. Makarov, Olga N. Ilinskaya, Nadezhda L. Mironova, Marina A. Zenkova
Publikováno v:
Biomolecules, Vol 10, Iss 11, p 1509 (2020)
The important role of miRNA in cell proliferation and differentiation has raised interest in exogenous ribonucleases (RNases) as tools to control tumour-associated intracellular and extracellular miRNAs. In this work, we evaluated the effects of the
Externí odkaz:
https://doaj.org/article/5447cbac80b4402c8796f22b3b9411ba