Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Andrey V. Cybulsky"'
Autor:
Andrey V. Cybulsky, Joan Papillon, Julie Guillemette, José R. Navarro-Betancourt, Chen-Fang Chung, Takao Iwawaki, I. George Fantus
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Protein misfolding in the endoplasmic reticulum (ER) of podocytes contributes to the pathogenesis of glomerular diseases. Protein misfolding activates the unfolded protein response (UPR), a compensatory signaling network. We address the role
Externí odkaz:
https://doaj.org/article/9013771e3f6a4da1928202208f87bf53
Publikováno v:
Physiological Reports, Vol 12, Iss 1, Pp n/a-n/a (2024)
Abstract SLK controls the cytoskeleton, cell adhesion, and migration. Podocyte‐specific deletion of SLK in mice leads to podocyte injury as mice age and exacerbates injury in experimental focal segment glomerulosclerosis (FSGS; adriamycin nephrosis
Externí odkaz:
https://doaj.org/article/983993ac9f3844aa8d8698faf39009c1
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 10 (2023)
Purpose of program: Adolescents and young adults with chronic disease face many personal and systemic barriers that may impede their successful transition from pediatric to adult care, putting them at risk for treatment nonadherence, loss to follow-u
Externí odkaz:
https://doaj.org/article/6afad67eb45446d4b423c25e19531617
Autor:
Chen-Fang Chung, Joan Papillon, José R. Navarro-Betancourt, Julie Guillemette, Ameya Bhope, Amin Emad, Andrey V. Cybulsky
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundHuman glomerulonephritis (GN)—membranous nephropathy (MN), focal segmental glomerulosclerosis (FSGS) and IgA nephropathy (IgAN), as well as diabetic nephropathy (DN) are leading causes of chronic kidney disease. In these glomerulopathies,
Externí odkaz:
https://doaj.org/article/0f84a28e78cc495ea2e2ba9ca816efb5
Autor:
Dylan Burger, Amira Abdelrasoul, R. Todd Alexander, Barbara Ballermann, Darren Bridgewater, John S. D. Chan, Joanna Cunanan, Andrey V. Cybulsky, Casimiro Gerarduzzi, Lakshman Gunaratnam, Sunny Hartwig, Andras Kapus, Christopher R. J. Kennedy, Caroline Lamarche, Robert L. Myette, Ifeanyi Kennedy Nmecha, Leanne Stalker, Katalin Szaszi, Elena Torban, Shao Ling Zhang, Tomoko Takano
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 9 (2022)
Purpose of conference: New discoveries arising from investigations into fundamental aspects of kidney development and function in health and disease are critical to advancing kidney care. Scientific meetings focused specifically on fundamental biolog
Externí odkaz:
https://doaj.org/article/00f789f8e446460c924fc806a84d3400
Publikováno v:
ACS Omega, Vol 5, Iss 25, Pp 15476-15486 (2020)
Externí odkaz:
https://doaj.org/article/c74a8801f88a47bda1acd37a8f8fba6d
Publikováno v:
Frontiers in Molecular Medicine. 2
Endoplasmic reticulum (ER) function is vital for protein homeostasis (“proteostasis”). Protein misfolding in the ER of podocytes (glomerular visceral epithelial cells) is an important contributor to the pathogenesis of human glomerular diseases.
Regulation of Ste20-like kinase, SLK, activity: Dimerization and activation segment phosphorylation.
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177226 (2017)
The Ste20-like kinase, SLK, has diverse cellular functions. SLK mediates organ development, cell cycle progression, cytoskeletal remodeling, cytokinesis, and cell survival. Expression and activity of SLK are enhanced in renal ischemia-reperfusion inj
Externí odkaz:
https://doaj.org/article/dc21ec78e1c848d580ebf409ccdc267f
Publikováno v:
Laboratory Investigation. 100:945-958
Podocyte injury and endoplasmic reticulum (ER) stress have been implicated in the pathogenesis of various glomerular diseases. ERdj3 (DNAJB11) and mesencephalic astrocyte-derived neurotrophic factor (MANF) are ER chaperones lacking the KDEL motif, an
Autor:
Joan Papillon, Andrey V. Cybulsky, Boyan Woychyshyn, José R. Navarro-Betancourt, Julie Guillemette
Publikováno v:
American Journal of Physiology-Renal Physiology. 318:F1377-F1390
Ste20-like kinase SLK is critical for embryonic development and may play an important role in wound healing, muscle homeostasis, cell migration, and tumor growth. Mice with podocyte-specific deletion of SLK show albuminuria and damage to podocytes as